Research progress of free radical induced aging

YANG Shan-lan; WU Lei; TU Jia-xin; DENG Li-fang; HUANG He-lang

doi:10.16462/j.cnki.zhjbkz.2022.05.017

Volume 26 Issue 5

May 2022

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YANG Shan-lan, WU Lei, TU Jia-xin, DENG Li-fang, HUANG He-lang. Research progress of free radical induced aging[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 589-594. doi: 10.16462/j.cnki.zhjbkz.2022.05.017

Citation:

YANG Shan-lan, WU Lei, TU Jia-xin, DENG Li-fang, HUANG He-lang. Research progress of free radical induced aging[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(5): 589-594. doi: 10.16462/j.cnki.zhjbkz.2022.05.017

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Research progress of free radical induced aging

doi: 10.16462/j.cnki.zhjbkz.2022.05.017

School of Public Health of Nanchang University, Jiangxi Province Key Laboratory of Preventive Medicine, Nanchang 330006, China

Funds:

National Natural Science Foundation of China 81960620

National Natural Science Foundation of China 81360446

More Information

Corresponding author: HUANG He-lang, E-mail: hhlang0821@sina.com
Received Date: 2021-08-11
Rev Recd Date: 2021-12-27

Available Online: 2022-05-11

Publish Date: 2022-05-10

Abstract

Abstract

The theory of free radical-induced aging (FRTA), first proposed by Denham Harman in 1954, believes that free radicals generated in the environment and from internal metabolism can damage cell components, thus damaging human function and accelerating aging. The research of human aging has developed rapidly, there are many theories and great debates, but the free radical theory has drawn wide attention. Most works of literature have given this theory some academic support as they affirm the fact that free radicals can cause aging and induce some chronic diseases. This paper summarizes the connotation and pathogenesis of free radicals from the aspects of biomedicine, molecular epidemiology and epidemiology, focuses on the progress of research on free radical in recent years and reveals the gap between the traditional understanding. At the same time, the paper puts forward a possible path of free radical-induced aging: free radicals act on the body continuously, dynamically and circularly. Aging can only occur when a certain cyclic balance is broken. This path brings opportunities and thoughts on preventing aging, reducing chronic diseases and delaying aging.
- Aging,
- Free radical,
- Oxidation,
- Adaptability

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References(55)

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