Associations of urinary polycyclic aromatic hydrocarbon metabolites with neurobehavioral function changes in coke oven workers

FU Meng-meng; WANG Hui-min; YAO Xi-yuan; MA Yi-fei; NIE Ji-sheng

doi:10.16462/j.cnki.zhjbkz.2022.08.010

Volume 26 Issue 8

Aug. 2022

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FU Meng-meng, WANG Hui-min, YAO Xi-yuan, MA Yi-fei, NIE Ji-sheng. Associations of urinary polycyclic aromatic hydrocarbon metabolites with neurobehavioral function changes in coke oven workers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 927-933. doi: 10.16462/j.cnki.zhjbkz.2022.08.010

Citation:

FU Meng-meng, WANG Hui-min, YAO Xi-yuan, MA Yi-fei, NIE Ji-sheng. Associations of urinary polycyclic aromatic hydrocarbon metabolites with neurobehavioral function changes in coke oven workers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 927-933. doi: 10.16462/j.cnki.zhjbkz.2022.08.010

Citation:

FU Meng-meng, WANG Hui-min, YAO Xi-yuan, MA Yi-fei, NIE Ji-sheng. Associations of urinary polycyclic aromatic hydrocarbon metabolites with neurobehavioral function changes in coke oven workers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 927-933. doi: 10.16462/j.cnki.zhjbkz.2022.08.010

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Associations of urinary polycyclic aromatic hydrocarbon metabolites with neurobehavioral function changes in coke oven workers

doi: 10.16462/j.cnki.zhjbkz.2022.08.010

Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China

Funds:

National Natural Science Foundation of China 82073526

National Natural Science Foundation of China 81673143

More Information

Corresponding author: NIE Ji-sheng, E-mail: niejisheng@sxmu.edu.cn
Received Date: 2022-03-29
Rev Recd Date: 2022-06-12

Available Online: 2022-08-23

Publish Date: 2022-08-10

Abstract

Abstract

Objective To investigate the associations between urinary polycyclic aromatic hydrocarbons (PAHs) metabolites and changes in coke oven workers' neurobehavioral function. Methods In 2017, 672 workers in a coking plant in Shanxi Province were investigated for basic conditions, neurobehavioral function tests and urinary PAHs detection. With follow-up in 2021, a total of 461 workers completed neurobehavioral functional tests. Neurobehavioral function was measured by neurobehavioral core test battery questionnaire. The concentrations of urinary PAHs metabolites and cotinine were determined by high-performance liquid chromatography-mass spectrometry. Generalized linear models and generalized estimation equations were used to analyze the association between urinary PAHs metabolites and neurobehavioral function. Results A total of 461 participants completed the investigation, the age was 34 (30, 46) years, and 69.2% was male at baseline. In the longitudinal study, forward digit span (β=-0.50, 95% CI: -0.81--0.18, P=0.002) and total digit span scores (β=-0.77, 95% CI: -1.38--0.16, P=0.014) were significantly lower in the 2-hydroxynaphthalene (2-OHNAP) high-exposure group; the mean reaction time (β=26.90, 95% CI: 7.86-45.93, P=0.006) was significantly longer in the 2-hydroxynaphthalenc (2-OHNAP) high-exposure group, the preferred hand (β=-1.30, 95% CI: -2.43--0.17, P=0.024) and non-preferred hand Santa Ana dexterity test (β=-1.19, 95% CI: -2.23--0.15, P=0.025) scores were significantly reduced in the 2-OHFLU high-exposure group. Conclusion Long-term exposure to polycyclic aromatic hydrocarbons reduces neurobehavioral function in coke oven workers.
- Polycyclic aromatic hydrocarbons,
- Neurobehavior,
- Neurobehavioral core test battery,
- Generalized estimation equation

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References(20)

References

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