Association between metabolic syndrome and aortic arch calcification: Guangzhou Biobank Cohort Study

LU An-ting; ZHANG Wei-sen; JIANG Chao-qiang; JIN Ya-li; CHENG Kar-keung; LAM Tai-hing; Xu Lin

doi:10.16462/j.cnki.zhjbkz.2022.08.012

Volume 26 Issue 8

Aug. 2022

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LU An-ting, ZHANG Wei-sen, JIANG Chao-qiang, JIN Ya-li, CHENG Kar-keung, LAM Tai-hing, Xu Lin. Association between metabolic syndrome and aortic arch calcification: Guangzhou Biobank Cohort Study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 939-944. doi: 10.16462/j.cnki.zhjbkz.2022.08.012

Citation:

LU An-ting, ZHANG Wei-sen, JIANG Chao-qiang, JIN Ya-li, CHENG Kar-keung, LAM Tai-hing, Xu Lin. Association between metabolic syndrome and aortic arch calcification: Guangzhou Biobank Cohort Study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 939-944. doi: 10.16462/j.cnki.zhjbkz.2022.08.012

Citation:

LU An-ting, ZHANG Wei-sen, JIANG Chao-qiang, JIN Ya-li, CHENG Kar-keung, LAM Tai-hing, Xu Lin. Association between metabolic syndrome and aortic arch calcification: Guangzhou Biobank Cohort Study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 939-944. doi: 10.16462/j.cnki.zhjbkz.2022.08.012

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Association between metabolic syndrome and aortic arch calcification: Guangzhou Biobank Cohort Study

doi: 10.16462/j.cnki.zhjbkz.2022.08.012

1.
Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
2.
Department of Molecular Epidemiology, Guangzhou No.12 Hospital, Guangzhou 510620, China
3.
Institute of Applied Health Research, University of Birmingham in UK, Birmingham B152TT, UK
4.
School of Public Health, University of Hong Kong, Hong Kong 999077, China

Funds:

National Natural Science Foundation of China 81941019

More Information

Corresponding author: XU Lin, E-mail: xulin27@mail.sysu.edu.cn
Received Date: 2021-11-09
Rev Recd Date: 2022-02-21

Available Online: 2022-08-23

Publish Date: 2022-08-10

Abstract

Abstract

Objective To examine the association between metabolic syndrome (MS) and aortic arch calcification (AAC) in middle-aged and older Chinese in Guangzhou. Methods Participants were from the Guangzhou Biobank Cohort Study recruited from 2003 to 2008. Face-to-face interviews, physical examinations, laboratory measurements and chest X-ray were used to collect information. Association between MS and AAC was analyzed by logistic regression. Stratification and interaction analysis was conducted according to different baseline characteristics. Results Of 25 824 participants included in this study, the prevalence of AAC in participants with MS was higher than in those without (χ² =150.3, P < 0.001). After adjusting for multiple confounding factors, the OR (95% CI) of AAC for MS was 1.19 (1.12-1.27) compared to those without. Among the components of MS, high levels of blood pressure, fasting plasma glucose (FPG) and triglycerides (TG), and low levels of high-density lipoprotein cholesterol (HDL-C) were positively associated with AAC independently, and the OR (95% CI) was 1.33 (1.26-1.41), 1.09 (1.03-1.15), 1.07 (1.01-1.14) and 1.14 (1.06-1.23), respectively. The odds of AAC increased significantly as the number of MS components increased (P_trend < 0.001). There was an interaction between age and MS on AAC, and the risk of AAC was higher in those aged 50- < 60 years with MS. Conclusions MS and its components such as high levels of blood pressure, TG, FPG and low levels of HDL-C were risk factors for AAC. Age modified the association between MS and AAC.
- Metabolic syndrome,
- Aortic arch calcification,
- Middle-aged and elder

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References(23)

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