Phylogenetic analysis of coxsackievirus A2 in China

LIANG Ruo-nan; SUN Tian-tian; JI Wang-quan; CHEN Shuai-yin; YANG Hai-yan; DUAN Guang-cai; JIN Yue-fei

doi:10.16462/j.cnki.zhjbkz.2022.08.018

Volume 26 Issue 8

Aug. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(8): 982-988

LIANG Ruo-nan, SUN Tian-tian, JI Wang-quan, CHEN Shuai-yin, YANG Hai-yan, DUAN Guang-cai, JIN Yue-fei. Phylogenetic analysis of coxsackievirus A2 in China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 982-988. doi: 10.16462/j.cnki.zhjbkz.2022.08.018

Citation:

LIANG Ruo-nan, SUN Tian-tian, JI Wang-quan, CHEN Shuai-yin, YANG Hai-yan, DUAN Guang-cai, JIN Yue-fei. Phylogenetic analysis of coxsackievirus A2 in China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 982-988. doi: 10.16462/j.cnki.zhjbkz.2022.08.018

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Phylogenetic analysis of coxsackievirus A2 in China

doi: 10.16462/j.cnki.zhjbkz.2022.08.018

Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China

Funds:

National Natural Science Foundation of China 82002147

National Natural Science Foundation of China 82073618

China Postdoctoral Science Foundation 2019M662543

Key Scientific Research Project of Henan Institution of Higher Education 20A330004

Key Scientific Research Project of Henan Institution of Higher Education 21A310026

More Information

Corresponding author: JIN Yue-fei, E-mail: jyf201907@zzu.edu.cn
Received Date: 2021-12-03
Rev Recd Date: 2022-03-22

Available Online: 2022-08-23

Publish Date: 2022-08-10

Abstract

Abstract

Objective To analyze the phylogenetic character of coxsackievirus A2 (CV-A2) strains in China. Methods Sequences of the VP1 region and complete genomes of CV-A2 strains in China were collected. The phylogenetic tree and analysis of amino acid mutation were conducted by MEGA 10.2.4 software. The analysis of genetic recombination was carried out through SimPlot 3.5.1 software. Results A total of 118 sequences of CV-A2 VP1 were collected, and 26 strains had complete genome sequences. CV-A2 strains mainly originated from Guangdong Province. The number of CV-A2 strains had increased rapidly since 2011. Phylogenetic tree based on the VP1 region was clustered into seven distinct lineages, and the prototype strains were a separate lineage A while most of strains gathered in lineages G. The analysis of gene recombination of CV-A2 representative strains with complete genome sequences exhibited recombinant segments. The amino acid variations were found at 22 sites of VP1 protein. Conclusion CV-A2 strains circulating in China have undergone gene recombination and mutations in the amino acid sites of the VP1 region, suggesting that monitoring the evolution of CV-A2 is of great significance for the prevention and control of hand-foot-mouth disease.
- Coxsackievirus A2,
- Systematic evolution,
- Gene recombination

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References(15)

References

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