The role of different forms of Gastrin on the pathogenesis of Helicobacter pylori

YUAN Xiao-gang; HUANG Xue-mei; XIANG Li; YAO Xin-huang

doi:10.16462/j.cnki.zhjbkz.2022.08.019

Volume 26 Issue 8

Aug. 2022

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(8): 989-992

YUAN Xiao-gang, HUANG Xue-mei, XIANG Li, YAO Xin-huang. The role of different forms of Gastrin on the pathogenesis of Helicobacter pylori[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 989-992. doi: 10.16462/j.cnki.zhjbkz.2022.08.019

Citation:

YUAN Xiao-gang, HUANG Xue-mei, XIANG Li, YAO Xin-huang. The role of different forms of Gastrin on the pathogenesis of Helicobacter pylori[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(8): 989-992. doi: 10.16462/j.cnki.zhjbkz.2022.08.019

Citation:

PDF( 768 KB)

The role of different forms of Gastrin on the pathogenesis of Helicobacter pylori

doi: 10.16462/j.cnki.zhjbkz.2022.08.019

1.
Department of Gastroenterology, Longgang District People's Hospital of Shenzhen, The Second Affiliated Hospital, The Chinese University of Hong Kong Shenzhen, Shenzhen 518172, China
2.
Gentral Laboratory, Department of Gastroenterology, Longggang District People's Hospital of Shenzhen/The Second Affiliated Hospital, The Chinese University of Hong Kong shenzhen, Shenzhen 518172, China

Funds:

Shenzhen Science and Technology Project JCYJ20180306170427637

Science and Technology Development Funds for Health Care Project of Longgang District, Shenzhen LGKCYLWS2019000151

More Information

Corresponding author: YUAN Xiao-gang, E-mail: xiaogangyuan@hotmail.com; YAO Xin-huang, E-mail: yxhh25@126.com
Received Date: 2021-12-26
Rev Recd Date: 2022-03-20

Available Online: 2022-08-23

Publish Date: 2022-08-10

Abstract

Abstract

Objective To investigate the effects of Helicobacter pylori (H.pylori) infection on serum gastrin and exosome derived gastrin secretion. Methods A total of 79 patients with non-atrophic gastritis (NAG) and atrophic gastritis (AG) were collected randomly. The infection of H.pylori was detected by a 13C-urea breath test. The concentration of serum gastrin and serum exosome derived gastrin were detected by enzyme-linked immunosorbent assay(ELISA). Results There was no significant difference in serum gastrin and exosome derived gastrin between NAG and AG group(t=-0.197, P=0.844; t=0.221, P=0.826). In NAG group, serum gastrin and exosome derived gastrin in H.pylori positive subgroup were significantly lower than those in H.pylori negative subgroups (t=2.488, P=0.017; t=2.655, P=0.012). In AG group, there was no significant difference in serum gastrin concentration between H. pylori positive and negative subgroups (t=1.888, P=0.082). However, exosome derived gastrin in H.pylori positive subgroup was significantly higher than that in H.pylori negative subgroup (t=2.394, P=0.029). Conclusions H.pylori infection may lead to the decrease of serum gastrin before gastric mucosal atrophy in the early stage. Serum gastrin and exosome derived gastrin in H. pylori positive AG group are significantly increased, which is an important carcinogenic mechanisms of H. pylori infection.
- Helicobacter pylori,
- Gastrin,
- Exosomes,
- Atrophic gastritis,
- Gastric carcinogenesis

FullText(HTML)

References(22)

References

[1]	Waldum H, Fossmark R. Gastritis, gastric polyps and gastric cancer[J]. Int J Mol Sci, 2021, 22(12): 6548. DOI: 10.3390/ijms22126548.
[2]	Waldum HL, Rehfeld JF. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia[J]. Scand J Gastroenterol, 2019, 54(9): 1118-1123. DOI: 10.1080/00365521.2019.1663446.
[3]	Shao Y, Sun K, Xu W, et al. Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis[J]. World J Gastroenterol, 2014, 20(36): 12860-12873. DOI: 10.3748/wjg.v20.i36.12860.
[4]	Khajeh S, Tohidkia MR, Aghanejad A, et al. Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells[J]. Artif Cells Nanomed Biotechnol, 2018, 46(sup2): 1082-1090. DOI: 10.1080/21691401.2018.1478846.
[5]	Osborne N, Sundseth R, Burks J, et al. Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment[J]. Cancer Immunol Immunother, 2019, 68(10): 1635-1648. DOI: 10.1007/s00262-019-02398-6.
[6]	Meng LL, Wang JL, Xu SP, et al. Low serum gastrin associated with ER(+) breast cancer development via inactivation of CCKBR/ERK/P65 signaling[J]. BMC Cancer, 2018, 18(1): 824. DOI: 10.1186/s12885-018-4717-7.
[7]	Li Y, Zhao Y, Li Y, et al. Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway[J]. J Physiol Biochem, 2021, 77(1): 93-104. DOI: 10.1007/s13105-020-00780-y.
[8]	Waldum HL, Rehfeld JF. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia[J]. Scand J Gastroenterol, 2019, 54(9): 1118-1123. DOI: 10.1080/00365521.2019.1663446.
[9]	Liu W, Sun Y, Yuan Y. Analysis of serum gastrin-17 and Helicobacter pylori antibody in healthy Chinese population[J]. J Clin Lab Anal, 2020, 34(12): e23518. DOI: 10.1002/jcla.23518.
[10]	Takaishi S, Cui G, Frederick DM, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer[J]. Gastroenterology, 2005, 128(7): 1965-1983. DOI: 10.1053/j.gastro.2005.03.027.
[11]	Waldum H. Gastrin drives gastric cancer due to oxyntic atrophy also after Helicobacter pylori eradication[J]. Therap Adv Gastroenterol, 2020, 13: 1756284820931717. DOI: 10.1177/1756284820931717.
[12]	Zagari RM, Rabitti S, Greenwood DC, et al. Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis[J]. Aliment Pharmacol Ther, 2017, 46(7): 657-667. DOI: 10.1111/apt.14248.
[13]	Graham DY. Letter: questions regarding the diagnostic performance of serum assays for atrophic gastritis[J]. Aliment Pharmacol Ther, 2017, 46(11-12): 1117-1118. DOI: 10.1111/apt.14339.
[14]	Wang R, Chen XZ. Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES)[J]. Sci Rep, 2020, 10(1): 4523. DOI: 10.1038/s41598-020-61472-7.
[15]	Han ML, Liou JM, Ser KH, et al. Changes of serum pepsinogen level and ABC classification after bariatric surgery[J]. J Formos Med Assoc, 2021, 120(6): 1377-1385. DOI: 10.1016/j.jfma.2020.10.029.
[16]	Wang Y, Liu X, Wang L, et al. A comparative study on changes in intestinal flora, pepsinogen and gastrin in patients with gastric cancer and atrophic gastritis[J]. J BUON, 2020, 5(2): 995-1000.
[17]	Chen XZ, Zhang WH, Chen HN, et al. Associations between serum CA724 and HER2 overexpression among stage Ⅱ-Ⅲ resectable gastric cancer patients: an observational study[J]. Oncotarget, 2016, 7: 23647-23657. DOI: 10.18632/oncotarget.8145.
[18]	Fu M, Gu J, Jiang P, et al. Exosomes in gastric cancer: roles, mechanisms, and applications[J]. Mol Cancer, 2019, 18(1): 41. DOI: 10.1186/s12943-019-1001-7.
[19]	Xia X, Zhang L, Chi J, et al. Helicobacter pylori infection impairs endothelial function through an exosome-mediated mechanism[J]. J Am Heart Assoc, 2020, 9(6): e014120. DOI: 10.1161/JAHA.119.014120.
[20]	Wang X, Ling L, Li S, et al. The diagnostic value of gastrin-17 detection in atrophic gastritis: a meta-analysis[J]. Medicine, 2016, 95(18): 1-9. DOI: 10.1097/MD.0000000000003599.
[21]	Liu W, Sun Y, Yuan Y. Analysis of serum gastrin-17 and Helicobacter pylori antibody in healthy Chinese population[J]. J Clin Lab Anal. 2020, 34(12): e23518. DOI: 10.1002/jcla.23518.
[22]	Parhusip DH, Siregar GA, Dairi LB. The difference of serum gastrin-17 level based on gastritis severity and Helicobacter pylori infection[J]. Maced J Med Sci, 2019, 7(8): 1266-1269. DOI: 10.3889/oamjms.2019.325.