Relationship between blood lipid level and hypertension in Xinjiang oil workers based on restricted cubic spline model

MUHEIYATI Guliman; MEI Yujie; TAO Ning

doi:10.16462/j.cnki.zhjbkz.2023.04.004

Volume 27 Issue 4

Apr. 2023

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MUHEIYATI Guliman, MEI Yujie, TAO Ning. Relationship between blood lipid level and hypertension in Xinjiang oil workers based on restricted cubic spline model[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(4): 392-398. doi: 10.16462/j.cnki.zhjbkz.2023.04.004

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MUHEIYATI Guliman, MEI Yujie, TAO Ning. Relationship between blood lipid level and hypertension in Xinjiang oil workers based on restricted cubic spline model[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(4): 392-398. doi: 10.16462/j.cnki.zhjbkz.2023.04.004

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Relationship between blood lipid level and hypertension in Xinjiang oil workers based on restricted cubic spline model

doi: 10.16462/j.cnki.zhjbkz.2023.04.004

1.
School of Public Health, Xinjiang Medical University, Key Laboratory of Special Environment and Health Research in Xinjiang, Urumqi 830011, China
2.
Xinjiang Clinical Research Center for Genitourinary System, Urumqi 830011, China

Funds:

Xinjiang Uygur Autonomous Region Youth Science and Technology Top Talent Project 2022TSYCCX0097

More Information

Corresponding author: TAO Ning, E-mail: 38518412@qq.com
Received Date: 2022-07-16
Rev Recd Date: 2022-10-29

Available Online: 2023-04-28

Publish Date: 2023-04-10

Abstract

Abstract

Objective To investigate the relationship between low-density lipoprotein (LDL), cholesterol (TC), and triglyceride glucose index (TyG) and the risk of hypertension in oil workers in Xinjiang. Methods From April to June 2021, 2 500 workers aged 18 to 65 years and with ≥1 year of service at six oilfield bases in Karamay, Xinjiang, were selected as the study population. The relationship between LDL, TC and TyG indices and hypertension in oil workers was analyzed by logistic regression models combined with restricted cubic splines. Results Comparison of age, smoking, alcohol consumption, hypertension, BMI, TC, triglycerides (TG), high-density lipoprotein (HDL), LDL, fasting glucose (FPG), TyG, and uric acid (UA) in different sex groups showed statistically significant differences (all P < 0.001). After correcting for relevant confounders, the risk of hypertension in the group with elevated LDL margins was 1.45 times higher than in the normal group. Compared with the normal TC group, the risk of hypertension was increased by 27% and 46% in the borderline elevated TC group and the elevated group, respectively. The risk of hypertension was 3.24 times higher in the highest quartile of TyG (Q4) than in the lowest quartile (Q1). The results of the stratified analysis showed that in men, the risk of hypertension was 1.37 and 1.43 times higher in the group with elevated marginal LDL and elevated TC, respectively, than in the normal group; in women, the risk of hypertension was 2.71 and 2.72 times higher in the group with elevated marginal LDL and elevated TC than in the normal group, respectively. The risk of hypertension was 2.65 times higher in the Q4 group than in the Q1 group in men and 4.60 times higher in the Q4 group than in the Q1 group in women. The results of restricted cubic splines showed that the dose response relationships between LDL, TC, and TyG indices and the risk of hypertension were inconsistent in both sexes. Conclusions Higher LDL, TC, and TyG indices are risk factors for hypertension in oil workers in Xinjiang, and hypertension can be effectively prevented by controlling lipid and blood glucose indices.
- Hypertension,
- Low density lipoprotein,
- Cholesterin,
- Triglyceride glucose product index

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