A two-sample Mendelian randomized study of causality between lncRNAs and lung adenocarcinoma

SUN Jihong; CONG Jing; WANG Pingyu

doi:10.16462/j.cnki.zhjbkz.2023.11.017

Volume 27 Issue 11

Nov. 2023

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SUN Jihong, CONG Jing, WANG Pingyu. A two-sample Mendelian randomized study of causality between lncRNAs and lung adenocarcinoma[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(11): 1350-1353. doi: 10.16462/j.cnki.zhjbkz.2023.11.017

Citation:

SUN Jihong, CONG Jing, WANG Pingyu. A two-sample Mendelian randomized study of causality between lncRNAs and lung adenocarcinoma[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(11): 1350-1353. doi: 10.16462/j.cnki.zhjbkz.2023.11.017

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A two-sample Mendelian randomized study of causality between lncRNAs and lung adenocarcinoma

doi: 10.16462/j.cnki.zhjbkz.2023.11.017

1.
Department of Epidemiology, School of Public Health and Management, Binzhou Medical University, Yantai 264003, China
2.
Department of Epidemiology, School of Public Health and Management, Binzhou Medical University, Public Health Division, Yantai Center for Disease Control and Prevention, Yantai 264003, China

Funds:

National Natural Science Foundation of China 81772281

Natural Science Foundation of Shandong Province ZR2020KH015

More Information

Corresponding author: WANG Pingyu, E-mail: wpingyugirl@163.com
Received Date: 2022-01-20
Rev Recd Date: 2022-06-09

Available Online: 2023-11-20

Publish Date: 2023-11-10

Abstract

Abstract

Objective A two-sample Mendelian randomization method was used to investigate the causal relationship between long-chain non-coding RNAs(lncRNAs) and the risk of lung adenocarcinoma. Methods The genome-wide association study data of lung adenocarcinoma and the cis-eQTL data set of eQTL Gene Alliance were used. The single nucleotide polymorphisms (SNPs) closely related to lung adenocarcinoma was used as a tool variable. Five two-sample Mendelian randomization models, including the inverse variance weighting method, MR-Egger regression model, weighted median analysis method, simple mode method and weighted mode method, were applied to evaluate the causal effect between lncRNAs and the risk of lung adenocarcinoma. Moreover, the heterogeneity test, gene pleiotropy test and sensitivity analysis were carried out to evaluate the reliability and stability of the results. Results PVT1, LINC00824, Z94721.1 exhibited significant association with lung adenocarcinoma (all P < 0.05). The OR was 0.79 (95% CI: 0.71-0.89) for PVT1 and 0.59 (95% CI: 0.42-0.83) for LINC00824, indicating that both PVT1 and LINC00824 reduced the risk of lung cancer. The OR was 1.09 (95% CI: 1.03-1.16) for Z94721.1, showing that Z94721.1 increased the risk of lung cancer. All passed the heterogeneity test, gene pleiotropy test and sensitivity analysis. Conclusions The three lncRNAs, PVT1, LINC00824 and Z94721.1, have stable causal association with lung adenocarcinoma, providing an important theoretical basis for the study of the pathogenesis of lung adenocarcinoma.
- Mendelian randomization,
- Long non-coding RNAs,
- Lung adenocarcinoma,
- Causal relationship

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References(18)

References

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