Effect of rapid progression on immune reconstitution after highly active anti-retroviral therapy in HIV/AIDS men who have sex with men

QIN Chuan; MENG Xinmei; ZHANG Peng; HU Jiaguang; LI Minji; HUANG Xiaohong; WEI Hongwei

doi:10.16462/j.cnki.zhjbkz.2023.12.006

Volume 27 Issue 12

Dec. 2023

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QIN Chuan, MENG Xinmei, ZHANG Peng, HU Jiaguang, LI Minji, HUANG Xiaohong, WEI Hongwei. Effect of rapid progression on immune reconstitution after highly active anti-retroviral therapy in HIV/AIDS men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(12): 1398-1402. doi: 10.16462/j.cnki.zhjbkz.2023.12.006

Citation:

QIN Chuan, MENG Xinmei, ZHANG Peng, HU Jiaguang, LI Minji, HUANG Xiaohong, WEI Hongwei. Effect of rapid progression on immune reconstitution after highly active anti-retroviral therapy in HIV/AIDS men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(12): 1398-1402. doi: 10.16462/j.cnki.zhjbkz.2023.12.006

Citation:

QIN Chuan, MENG Xinmei, ZHANG Peng, HU Jiaguang, LI Minji, HUANG Xiaohong, WEI Hongwei. Effect of rapid progression on immune reconstitution after highly active anti-retroviral therapy in HIV/AIDS men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(12): 1398-1402. doi: 10.16462/j.cnki.zhjbkz.2023.12.006

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Effect of rapid progression on immune reconstitution after highly active anti-retroviral therapy in HIV/AIDS men who have sex with men

doi: 10.16462/j.cnki.zhjbkz.2023.12.006

QIN Chuan^{1, 2, 3},
MENG Xinmei^{1, 2, 3},
ZHANG Peng^{1, 2, 3},
HU Jiaguang^{1, 2, 3},
LI Minji^{1, 2, 3},
HUANG Xiaohong^{1, 2, 3},
WEI Hongwei^{4
,
,}

1.
Department of Infectious Diseases Section, Liuzhou People′s Hospital, Liuzhou 545006, China
2.
Guangxi Key Laboratory for Biotechnology of Clinical Disease, Liuzhou 545006, China
3.
Liuzhou Key Laboratory for Immunization Research of Infectious Disease, Liuzhou 545006, China
4.
General Medicine Department, Liuzhou People′s Hospital, Liuzhou 545006, China

Funds:

Guangxi Zhuang Autonomous Region Health and Family Planning Commission Self-Funded Scientific Research Project Z20180286

More Information

Corresponding author: WEI Hongwei, E-mail: 13607722185@163.com
Received Date: 2021-10-15
Rev Recd Date: 2022-03-27
Publish Date: 2023-12-10

Abstract

Abstract

Objective To explore the effect of rapid disease progression on immune reconstitution after highly active anti-retroviral therapy (HAART) in HIV/AIDS MSM. Methods A total of 108 HIV/AIDS MSM were divided into rapid progression group (n=68) and non-rapid progression group (n=40). The recovery of immune reconstitution related indexes in two groups after HAART 24 months were statistically analyzed. Results During the progress of HAART, CD4⁺T cell (CD4) count and CD4/CD8⁺T cell (CD8) ratio in both groups gradually increased, and CD4/CD8 ratio in rapid progression group was lower than that in non-rapid progression group (0.62±0.29 vs. 0.84±0.33, F=4.244, P=0.042) after 24 months of HAART initiation. The baseline CD8 count in rapid progression group (933±430) was lower than that in non-rapid progression group (1 248±476) (t=3.515, P=0.001), and then CD8 count in both groups gradually decreased to a similar level (F=0.110, P=0.741), with smaller decline in rapid progression group than in non-rapid progression group. Conclusion For HIV/AIDS MSM, the rapid disease progression will have a negative effect on immune reconstitution of HAART.
- Men who have sex with men,
- HIV,
- AIDS,
- Highly active anti-retroviral therapy

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References(13)

References

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