Study on the load level, composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing

SONG Yu; ZHOU Niya; WANG Xiaogang; YANG Huifang; CAO Jia

doi:10.16462/j.cnki.zhjbkz.2024.05.002

Volume 28 Issue 5

May 2024

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SONG Yu, ZHOU Niya, WANG Xiaogang, YANG Huifang, CAO Jia. Study on the load level, composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 503-509. doi: 10.16462/j.cnki.zhjbkz.2024.05.002

Citation:

SONG Yu, ZHOU Niya, WANG Xiaogang, YANG Huifang, CAO Jia. Study on the load level, composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 503-509. doi: 10.16462/j.cnki.zhjbkz.2024.05.002

Citation:

SONG Yu, ZHOU Niya, WANG Xiaogang, YANG Huifang, CAO Jia. Study on the load level, composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(5): 503-509. doi: 10.16462/j.cnki.zhjbkz.2024.05.002

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Study on the load level, composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing

doi: 10.16462/j.cnki.zhjbkz.2024.05.002

SONG Yu^{1, 2},
ZHOU Niya^{3, 4},
WANG Xiaogang²,
YANG Huifang^{1
,
,},
CAO Jia^{2
,
,}

1.
School of Public Health, Ningxia Medcial University, Yinchuan 750004, China
2.
Institute of Toxicology, Faculty of Military Preventive Medicine, Army Military Medical University (Third Military Medical University), Chongqing 400038, China
3.
Chongqing Health Center for Women and Children/Department of Clinical Research Center of Science and Education, Women and Children′s Hospital of Chongqing Medical University, Chongqing 401147, China
4.
Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing 401147, China

Funds:

National Natural Science Foundation of China 82130097

National Key Research and Development Program of China 2022YFC2702902

More Information

Corresponding author: YANG Huifang, E-mail: joyceyhf@163.com; CAO Jia, E-mail: caojia1962@126.com
Received Date: 2023-12-21
Rev Recd Date: 2024-02-26

Available Online: 2024-06-05

Publish Date: 2024-05-10

Abstract

Abstract

Objective To evaluate the organophosphate flame retardants (OPFRs) loads of pregnant women and newborns in Chongqing and its relationship, components and correlation. Methods Date were drawn from The Preconception Reproductive Health and Birth Outcome Cohort (PREBIC), and a total of 221 healthy pregnant women-newborns pairs who delivered in Chongqing Maternal and Child Health Hospital from November 2020-November 2021 were included in the final analysis. The levels of 8 mOPFRs in serum were detected by liquid chromatography/mass spectrometry. The Spearman rank correlation analysis was used to analyze the association of 8 mOPFRs exposure levels in peripheral venous blood of pregnant women and umbilical cord blood of newborns. Results The detection rate of total mOPFRs(∑mOPFRs) in peripheral venous blood of pregnant women was 84.6%, and the detection rate of each mOPFRs ranged from 12.7% to 76.9%; the detection rate of ∑mOPFRs in umbilical cord blood of newborns was 93.2%, and the detection rate of each mOPFRs ranged from 1.8% to 91.0%. di-o-tolyl phosphate(DoCP) & di-o-tolyl phosphate(DpCP) and bis(2-ethylhexyl)phthalate(BEHP) in peripheral venous blood of pregnant women were correlated with the concentrations in umbilical cord blood of newborns (r=0.29 and 0.22, P < 0.05). Conclusions A variety of mOPFRs were detected in peripheral venous blood of pregnant women and umbilical cord blood of newborns in Chongqing, and there was a correlation between the levels of mOPFRs in pregnant women and newborns.
- Organophosphate flame retardants,
- Pregnant women,
- Newborns

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References(23)

References

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