Mendelian randomization study on the causal relationship between interleukins and pulmonary tuberculosis

WANG Xingbin; ZHAO Changming; HUANG Qiuli; WANG Ling; ZHANG Yaxin; YANG Dejie; WANG Zhaofen

doi:10.16462/j.cnki.zhjbkz.2024.07.013

Volume 28 Issue 7

Jul. 2024

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WANG Xingbin, ZHAO Changming, HUANG Qiuli, WANG Ling, ZHANG Yaxin, YANG Dejie, WANG Zhaofen. Mendelian randomization study on the causal relationship between interleukins and pulmonary tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 827-832. doi: 10.16462/j.cnki.zhjbkz.2024.07.013

Citation:

WANG Xingbin, ZHAO Changming, HUANG Qiuli, WANG Ling, ZHANG Yaxin, YANG Dejie, WANG Zhaofen. Mendelian randomization study on the causal relationship between interleukins and pulmonary tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 827-832. doi: 10.16462/j.cnki.zhjbkz.2024.07.013

Citation:

WANG Xingbin, ZHAO Changming, HUANG Qiuli, WANG Ling, ZHANG Yaxin, YANG Dejie, WANG Zhaofen. Mendelian randomization study on the causal relationship between interleukins and pulmonary tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 827-832. doi: 10.16462/j.cnki.zhjbkz.2024.07.013

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Mendelian randomization study on the causal relationship between interleukins and pulmonary tuberculosis

doi: 10.16462/j.cnki.zhjbkz.2024.07.013

1.
Department of Public Health, Medical School, Qinghai University, Xining 810001, China
2.
Xiguan Community Hospital, Chengxi District, Xining 810007, China

Funds:

Natural Science Foundation of Qinghai Province 2020-ZJ-929

More Information

Corresponding author: WANG Zhaofen, E-mail: kristy538@163.com
Received Date: 2023-10-07
Rev Recd Date: 2024-04-19

Available Online: 2024-08-19

Publish Date: 2024-07-10

Abstract

Abstract

Objective This study aims to determine the causal association between multiple interleukin (IL) levels and the risk of tuberculosis by using a two-sample Mendelian randomization (MR) method. Methods The data on interleukins and tuberculosis were obtained from the the pooled data of three published genome-wide association studies(GWAS) accomplished in European populations. According to preset thresholds and requirements of linkage disequilibrium, the single nucleotide polymorphism(SNP) loci closely related to a variety of interleukins were extracted from the summarized data as instrumental variables, the causal effect of nine interleukin levels on the risk of tuberculosis was assessed by using inverse variance weighting (IVW), mr-egger regression, and weighted median estimation. At the same time, the horizontal pleiotropy and heterogeneity were tested to ensure the stability of the results, and the directional test was used to check reverse causality effect. Results According to the IVW results, there were no causal relationships among interleukins of IL-1RA, IL-2RA, IL-6, IL-6RA, IL-8, IL-17, IL-18 and pulmonary tuberculosis (P>0.05). Higher levels of IL-16 were correlated with an increased risk of tuberculosis (OR=1.210, 95% CI: 1.032-1.419, P=0.019, P_adjusted=0.086). In contrast, rised IL-27 levels suggested a lower risk of tuberculosis (OR=0.875, 95% CI: 0.788-0.97, P=0.011, P_adjusted=0.086). These findings remained robust and consistent across all three MR testing methods with no reverse causality. Conclusions No causal relationship has been found among interleukins of IL-1RA, IL-2RA, IL-6, IL-6RA, IL-8, IL-17, IL-18 and pulmonary tuberculosis. Higher IL-16 levels are linked to an increased risk of developing tuberculosis, while the increase in IL-27 levels is associated with a decreased risk of pulmonary tuberculosis.
- Mendelian randomization,
- Interleukins,
- Pulmonary tuberculosis,
- Causal association

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References(25)

References

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