Effect of lead exposure on thyroid hormone levels in occupationally exposed populations: a Meta-analysis

PENG Xiaokun; HAN Junyu; JING Nan; YANG Qianlei; ZHANG Hengdong; AN Yan

doi:10.16462/j.cnki.zhjbkz.2024.07.017

Volume 28 Issue 7

Jul. 2024

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PENG Xiaokun, HAN Junyu, JING Nan, YANG Qianlei, ZHANG Hengdong, AN Yan. Effect of lead exposure on thyroid hormone levels in occupationally exposed populations: a Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 856-863. doi: 10.16462/j.cnki.zhjbkz.2024.07.017

Citation:

PENG Xiaokun, HAN Junyu, JING Nan, YANG Qianlei, ZHANG Hengdong, AN Yan. Effect of lead exposure on thyroid hormone levels in occupationally exposed populations: a Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 856-863. doi: 10.16462/j.cnki.zhjbkz.2024.07.017

Citation:

PENG Xiaokun, HAN Junyu, JING Nan, YANG Qianlei, ZHANG Hengdong, AN Yan. Effect of lead exposure on thyroid hormone levels in occupationally exposed populations: a Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(7): 856-863. doi: 10.16462/j.cnki.zhjbkz.2024.07.017

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Effect of lead exposure on thyroid hormone levels in occupationally exposed populations: a Meta-analysis

doi: 10.16462/j.cnki.zhjbkz.2024.07.017

PENG Xiaokun¹,
HAN Junyu¹,
JING Nan¹,
YANG Qianlei¹,
ZHANG Hengdong^{2, 3
,
,},
AN Yan^{1
,
,}

1.
Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China
2.
Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
3.
Jiangsu Preventive Medicine Association, Nanjing 210009, China

Funds:

National Natural Science Foundation of China 81872646

National Natural Science Foundation of China 81811540034

National Natural Science Foundation of China 81573173

Scientific Research Project of Jiangsu Provincial Health Commission ZD2021024

Key Medical Sciences of Jiangsu Province ZDXK202249

More Information

Corresponding author: ZHANG Hengdong, E-mail: hd-zhang@263.net; AN Yan, E-mail: dranyan@126.com
Received Date: 2023-04-21
Rev Recd Date: 2024-05-13

Available Online: 2024-08-19

Publish Date: 2024-07-10

Abstract

Abstract

Objective Meta-analysis was used to explore the relationship between blood lead levels and thyroid hormone (TH) levels in people with occupational lead exposure. Methods Meta-analysis was performed using Stata14.0. Chinese and English databases, including CNKI, Wanfang Data Knowledge Service Platform, Chinese Science and Technology Journal Database, PubMed, Web of Science were searched. Cross-sectional studies on the relationship between lead exposure and thyroid hormone levels published from the databases establishment to October 2022 were collected. Results A total of 14 literatures were included for analysis. The results showed that compared with control population, the blood lead level was higher in people with occupational lead exposure. There was no statistical significance (all P > 0.05) in the average concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), free triiodothyronine (FT4) and free thyroxine (FT4) between the two groups. When the blood lead level in the exposed group was higher than 200 μg/L, the TSH level increased, and the difference between the exposed group and the control group was statistically significant (P < 0.05). Conclusions High blood lead level is associated with elevated TSH level in people with occupational lead exposure.
- Occupational,
- Lead exposure,
- Blood lead level,
- Thyroid hormone,
- Thyroid stimulating hormone,
- Cross-sectional study,
- Meta-analysis

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References(30)

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