Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods

XU Lihua; FEI Xiulan; CHEN Faqing; LI Qinglin; SUN Wei; WANG Tao; WANG Yanling

doi:10.16462/j.cnki.zhjbkz.2024.08.008

Volume 28 Issue 8

Aug. 2024

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XU Lihua, FEI Xiulan, CHEN Faqing, LI Qinglin, SUN Wei, WANG Tao, WANG Yanling. Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008

Citation:

XU Lihua, FEI Xiulan, CHEN Faqing, LI Qinglin, SUN Wei, WANG Tao, WANG Yanling. Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008

Citation:

XU Lihua, FEI Xiulan, CHEN Faqing, LI Qinglin, SUN Wei, WANG Tao, WANG Yanling. Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008

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Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods

doi: 10.16462/j.cnki.zhjbkz.2024.08.008

1.
Institute of Endemic Diseases, Gansu Provincial Centre for Disease Control and Prevention, Lanzhou 730000, China
2.
Nanchong City Hospital of Traditional Chinese Medicine Medical Department, Nanchong 637000, China

Funds:

Gansu Provincial Health Industry Scientific Research Program Project GSWSKY2021-008

More Information

Corresponding author: WANG Yanling, E-mail : wylxiao@126.com
Received Date: 2024-01-18
Rev Recd Date: 2024-05-17

Available Online: 2024-09-29

Publish Date: 2024-08-10

Abstract

Abstract

Objective To analyze the influencing factors of thyroid volume at children aged 6-12 years in Gansu Province, and to explore the appropriate correction method of thyroid volume. Methods Based on the results of the 2019 iodine deficiency disease monitoring in Gansu Province, Liangzhou District of Wuwei City and Kongtong District of Pingliang City, where iodine nutrition is appropriate, were selected as survey sites. A multi-stage stratified sampling method was used to extract non-residential children aged 6-12 years (with balanced regional and gender ratio). The height, weight, thyroid volume, urinary iodine and salt iodine in their families were measured. The influencing factors of thyroid volume in children were analyzed. The thyroid volume correction effects of body mass volume index (BMIV), body surface area volume index (BSAV), weight height volume index (WHVI), height volume index (WHVI), height volume index1 (HVI1) and height volume index2 (HVI2) were compared. Results Thyroid volume was not statistically significant when children of different genders (Z=-0.837, P=0.403). Spearman rank correlation analysis showed that height, body weight, BMI, body surface area (BSA), age, urinary iodine were positively correlated with thyroid volume (P < 0.001). Among them, BSA had the strongest correlation with thyroid volume (r=0.787). Quantile regression analysis showed that age and BSA had significant effects on the overall distribution of thyroid volume. Spearman rank correlation analysis of height, weight and corrected thyroid volume showed that BSAV could eliminate the influence of height and weight on thyroid volume to the greatest extent. Conclusions Age and BSA significantly affected thyroid volume. BSAV has a good correction effect on children′s thyroid volume, and it is recommended to be used as an evaluation index of children′s thyroid volume.
- Children,
- Thyroid volume,
- Influencing factors,
- Correction methods

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References(16)

References

[1]	Gyamfi D, Wiafe Ya, Ofori Awuah E, et al. Goitre prevalence and urinary iodine concentration in school-aged children in the Ashanti region of Ghana[J]. Int J Endocrinol, 2020, 20203759786. DOI: 10.1155/2020/3759786.
[2]	Chen W, Zhang Q, Wu Y, et al. Shift of reference values for thyroid volume by ultrasound in 8-to13-year-olds with sufficient iodine intake in China[J]. Thyroid, 2019, 29(3): 405-411. DOI: 10.1089/thy.2018.0412.
[3]	中华人民共和国卫生部. 地方性甲状腺肿诊断准(WS 276-2007)[M]. 北京: 中国标准出版社, 2007: 1-4. Ministry of Health of the People′s Republic of China. Diagnostic criteria for endemic goiter (WS 276-2007)[M]. Beijing: China Standard Press, 2007: 1-4.
[4]	Liu L, Qian T, Sun R, et al. Comparative analysis of five correction methods for thyroid volume by ultrasound and their recommended reference values in Chinese children aged 8-10 years[J]. Br J Nutr, 2022: 1-28. DOI: 10.1017/s0007114522001003.
[5]	宋选波, 李津蜀, 张莉莉, 等. 四川省8~10岁儿童甲状腺容积相关影响因素分析及不同甲状腺容积指数比较[J]. 中华地方病学杂志, 2022, 41(8): 664-668. DOI: 10.3760/cma.j.cn231583-20211008-00338. Song XB, Li JS, Zhang LL, et al. Analysis of thyroid volume-related influencing factors and comparison of different thyroid volume indices in children aged 8-10 years in Sichuan Province[J]. Chin J Endemiol, 2022, 41(8): 664-668. DOI: 10.3760/cma.j.cn231583-20211008-00338.
[6]	窦瑜贵, 王燕玲, 曹永琴, 等. 2019年甘肃省碘缺乏病监测结果分析[J]. 中华地方病学杂志, 2022, 41(4): 284-289. DOI: 10.3760/cma.j.cn231583-20210302-00060. Dou YG, Wang YL, Cao YQ, et al. Analysis of iodine deficiency disease monitoring results in Gansu Province in 2019[J]. Chin J Endemiol, 2022, 41(4): 284-289. DOI: 10.3760/cma.j.cn231583-20210302-00060.
[7]	中华人民共和国国家卫生和计划生育委员会. 尿中碘的测定第1部分: 砷铈催化分光光度法(WS/T 107.1-2016)[M]. 北京: 中国标准出版社, 2016: 1-5. National Health and Family Planning Commission of the People′s Republic of China. Determination of iodine in urine part 1: Arsenic-cerium catalyzed spectrophotometric method (WS/T 107.1-2016)[M]. Beijing: China Standard Press, 2016: 1-5.
[8]	Unicef Ouncf, Ign Oign. Guidance on the monitoring of salt iodization programmes and determination of population iodine status: russian language version[J]. Clinical and Experimental Thyroidology, 2018, 14(2): 100-112. DOI: 10.14341/ket9734.
[9]	中华人民共和国国家质量监督检验检疫总局, 中国国家标准化管理委员会. 制盐工业通用试验方法碘的测定(GB/T 13025. 7-2012)[M]. 北京: 中国标准出版社, 2013: 1-3. General Administration of Quality Supervision, Inspection and Quarantine of the People′s Republic of China, Standardization Administration of the People′s Republic of China. General test method for salt industry determination of iodine (GB/T 13025.7-2012)[M]. Beijing: China Standard Press, 2013: 1-3.
[10]	中华人民共和国卫生部. 食品安全国家标准食用盐碘含量(GB 26878-2011)[M]. 北京: 中国标准出版社, 2011: 1-1. Ministry of Health of the People′s Republic of China. National standards for food safety-iodine content of edible salt (GB 26878-2011)[M]. Beijing: Standards Press of China, 2011: 1-1.
[11]	Zimmermann Michael B, Hess Sonja Y, Molinari L, et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for health and development iodine deficiency study group report[J]. Am J Clin Nutr, 2004, 79(2): 231-237. DOI: 10.1093/ajcn/79.2.231.
[12]	Liu L, Liu L, Li M, et al. Study on association between height, weight, iodine supplementation and thyroid volume[J]. Br J Nutr, 2022, 127(9): 1358-1366. DOI: 10.1017/s0007114521002622.
[13]	An S, Li W, Wang X, et al. Study on influential factors and reference values for thyroid volume in Chinese children aged 6-12 years[J]. Br J Nutr, 2022: 1-9. DOI: 10.1017/s0007114522002070.
[14]	Cui Y, Wang Y, Zhang D, et al. Reference intervals for thyroid hormones and thyroid volume in children aged 7~13 years from iodine-sufficient areas in Tianjin, China[J]. Biol Trace Elem Res, 2023, 201(12): 5575-5584. DOI: 10.1007/s12011-023-03624-0.
[15]	张根红, 王羽. 非缺碘性因素对儿童甲状腺容积影响的研究[J]. 中国地方病学杂志, 2000, 19(2): 2. DOI: 10.3760/cma.j.issn.1000-4955.2000.02.019. Zhang GH, Wang Y. Study on the effect of non-iodine deficiency factors on thyroid volume in children[J]. Chin J Endemiol, 2000, 19(2): 2. DOI: 10.3760/cma.j.issn.1000-4955.2000.02.019.
[16]	王木华, 季淑眯, 陈迪群, 等. 福建省8~10岁儿童不同甲状腺容积校正指数结果比较[J]. 中华疾病控制杂志, 2023, 27(9): 1010-1012. DOI: 10.16462/j.cnki.zhjbkz.2023.09.004. Wang MH, Ji SM, Chen DQ, et al. Comparison of the results of different thyroid volume correction indices in children aged 8-10 years in Fujian Province[J]. Chin J Dis Control Prev, 2023, 27(9): 1010-1012. DOI: 10.16462/j.cnki.zhjbkz.2023.09.004.