Characterization of hepatitis B virus infection status and amino acid variations in the S region of the virus in a hospital population undergoing physical examination in Tibet

XU Linli; YUAN Xiaojie; ZHANG Weilu; LI Hongyan; JI Zhaohua; WANG Yuhua; LI Yijun; WANG Yuemei; SHAO Zhongjun

doi:10.16462/j.cnki.zhjbkz.2024.11.005

Volume 28 Issue 11

Nov. 2024

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XU Linli, YUAN Xiaojie, ZHANG Weilu, LI Hongyan, JI Zhaohua, WANG Yuhua, LI Yijun, WANG Yuemei, SHAO Zhongjun. Characterization of hepatitis B virus infection status and amino acid variations in the S region of the virus in a hospital population undergoing physical examination in Tibet[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1270-1274. doi: 10.16462/j.cnki.zhjbkz.2024.11.005

Citation:

XU Linli, YUAN Xiaojie, ZHANG Weilu, LI Hongyan, JI Zhaohua, WANG Yuhua, LI Yijun, WANG Yuemei, SHAO Zhongjun. Characterization of hepatitis B virus infection status and amino acid variations in the S region of the virus in a hospital population undergoing physical examination in Tibet[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1270-1274. doi: 10.16462/j.cnki.zhjbkz.2024.11.005

Citation:

XU Linli, YUAN Xiaojie, ZHANG Weilu, LI Hongyan, JI Zhaohua, WANG Yuhua, LI Yijun, WANG Yuemei, SHAO Zhongjun. Characterization of hepatitis B virus infection status and amino acid variations in the S region of the virus in a hospital population undergoing physical examination in Tibet[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1270-1274. doi: 10.16462/j.cnki.zhjbkz.2024.11.005

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Characterization of hepatitis B virus infection status and amino acid variations in the S region of the virus in a hospital population undergoing physical examination in Tibet

doi: 10.16462/j.cnki.zhjbkz.2024.11.005

1.
Department of Epidemiology, School of Public Health, Fourth Military Medical University, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi′an 710032, China
2.
Fukang Hospital Affiliated to Tibet University, Lhasa 850000, China

Funds:

Natural Science Basic Research Program of Shaanxi 2023-JC-QN-0987

More Information

Corresponding author: SHAO Zhongjun, E-mail: 13759981783@163.com
Received Date: 2024-06-12
Rev Recd Date: 2024-09-09

Available Online: 2024-12-23

Publish Date: 2024-11-10

Abstract

Abstract

Objective To probe the status of hepatitis B virus infection in the physical examination population of the Tibet Autonomous Region and to clarify the distribution characteristics of hepatitis B virus genotypes and the amino acid variants in the S region. Methods The health check-up population in a hospital in Tibet from May 2022 to July 2023 was selected as the study population, and questionnaires and serologic tests were conducted on the check-up population using random sampling method. According to the results of hepatitis B serologic markers, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), hepatitis B core antibody (anti-HBc) positive samples were subjected to S region gene amplification and amino acid variation analysis. Results A total of 3 970 medical examiners were included, and eight combinations of serum markers were detected for HBsAg, antibody to hepatitis B surface antigen (anti-HBs), and anti-HBc. Differences in the prevalence of HBV infection and the positive rate of single anti-HBc were statistically significant across varing groups including age, gender, occupation, marital status and region (all P < 0.001). The S region sequences were amplified from 48 samples, and the typing results were 39 cases of genotype D, 8 cases of genotype C and 1 case of genotype B, of which 13 cases had amino acid mutations in the major hydrophilic region (MHR) of the S genetic region. Conclusions The Tibet Autonomous Region is a highly endemic area for hepatitis B. The HBV genotype is mainly genotype D and the amino acid sequence of the major hydrophilic region in the S region of HBV has mutations at several sites, so it is necessary to actively carry out vaccination measures against hepatitis B in adults.
- Hepatitis B virus,
- Serological pattern,
- Variation analysis

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References(18)

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