A prospective study on the incidence and influencing factors of type 2 diabetes mellitus in rural population in Xinjiang

QIAO Zheng; MA Rulin; GUO Heng; ZHANG Xianghui; HE Jia; WANG Xinping; MULATIBIEKE Keerman; GUO Shuxia

doi:10.16462/j.cnki.zhjbkz.2024.11.012

Volume 28 Issue 11

Nov. 2024

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(11): 1316-1320

QIAO Zheng, MA Rulin, GUO Heng, ZHANG Xianghui, HE Jia, WANG Xinping, MULATIBIEKE Keerman, GUO Shuxia. A prospective study on the incidence and influencing factors of type 2 diabetes mellitus in rural population in Xinjiang[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1316-1320. doi: 10.16462/j.cnki.zhjbkz.2024.11.012

Citation:

QIAO Zheng, MA Rulin, GUO Heng, ZHANG Xianghui, HE Jia, WANG Xinping, MULATIBIEKE Keerman, GUO Shuxia. A prospective study on the incidence and influencing factors of type 2 diabetes mellitus in rural population in Xinjiang[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1316-1320. doi: 10.16462/j.cnki.zhjbkz.2024.11.012

Citation:

QIAO Zheng, MA Rulin, GUO Heng, ZHANG Xianghui, HE Jia, WANG Xinping, MULATIBIEKE Keerman, GUO Shuxia. A prospective study on the incidence and influencing factors of type 2 diabetes mellitus in rural population in Xinjiang[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1316-1320. doi: 10.16462/j.cnki.zhjbkz.2024.11.012

PDF( 955 KB)

A prospective study on the incidence and influencing factors of type 2 diabetes mellitus in rural population in Xinjiang

doi: 10.16462/j.cnki.zhjbkz.2024.11.012

Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi 832000, China

Funds:

National Natural Science Foundation of China 81560551

More Information

Corresponding author: GUO Shuxia, E-mail: 2320100252@qq.com
Received Date: 2024-04-24
Rev Recd Date: 2024-08-31

Available Online: 2024-12-23

Publish Date: 2024-11-10

Abstract

Abstract

Objective This study aims to explore the incidence and influencing factors of type 2 diabetes mellitus (T2DM) among rural populations in Xinjiang, comparing risk factors between the Uyghur and Kazakh ethnic groups and proposing targeted prevention measures. Methods Two representative regions in the Xinjiang were selected for questionnaire surveys, physical exams, and blood sample collection from the study subjects in 2010 and 2016, with follow-up studies from 2013 to 2017 (Kazakh) and 2019 to 2022 (Uyghur), Populations with a follow-up period of at least 5 years were selected as the study subjects. The Cox proportional hazards regression model was employed to assess the relationship between influencing factors and the risk of T2DM. Results The study included a total of 5 714 participants, including 3 304 Uygur ethnic group participants and 2 410 Kazakh ethnic group participants. During the follow-up period, 428 new cases of T2DM were reported in the Uygur group and 165 new cases in the Kazakh group. The cumulative incidence of new-onset T2DM was 13.0% in the Uyghur population, higher than the 6.8% in the Kazakh population. Common risk factors for both groups include older age, family history of T2DM, obesity, hypertension, and abnormal triglycerides (TG). Additional risk factors specific to the Uyghur group are abnormal LDL-C and HDL-C, while those specific to the Kazakh group include male, being overweight, and abnormal total cholesterol (TC). Conclusions T2DM incidence is higher among the Uyghur population than the Kazakh population. There are notable differences in the incidence factors and correlation strengths of T2DM between the two ethnic groups. Given the varying lifestyles and ethnic characteristics, it is essential to implement tailored prevention and control measures for T2DM.
- People living in rural areas,
- Type 2 diabetes mellitus,
- Prospective study

FullText(HTML)

References(23)

References

[1]	Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation [J]. Diabet Med, 1998, 15(7): 539-553. DOI: 10.1002/(SICI)1096-9136(199807)15:7<539:AID-DIA668>3.0.CO;2-S.
[2]	马丽媛, 王增武, 樊静, 等. 《中国心血管健康与疾病报告2022》要点解读[J]. 中国全科医学, 2023, 26(32): 3975-3994. DOI: 10.12114/j.issn.1007-9572.2023.0408. Ma LY, Wang ZW, Fan J, et al. Interpretation of report on cardiovascular health and diseases in China 2022 [J]. Chin Gen Pract, 2023, 26(32): 3975-3994. DOI: 10.12114/j.issn.1007-9572.2023.0408.
[3]	庄建文, 朱熠, 潘颖颖, 等. 新疆生产建设兵团居民慢性病流行病学调查分析[J]. 兵团医学, 2021, 19(4): 44-46. DOI: 10.3969/j.issn.1672-4356.2021.04.023. Zhuang JW, Zhu Y, Pan YY, et al. Epidemiological investigation and analysis of chronic diseases among residents of Xinjiang production and construction corps [J]. J Bingtuan Med, 2021, 19(4): 44-46. DOI: 10.3969/j.issn.1672-4356.2021.04.023.
[4]	Xu R, Zheng TJ, Ouyang CQ, et al. Causal associations between site-specific cancer and diabetes risk: a two-sample Mendelian randomization study [J]. Front Endocrinol, 2023, 14: 1110523. DOI: 10.3389/fendo.2023.1110523.
[5]	Chen JD, Cao SH, Jin Y, et al. Construction and validation of a nomogram of risk factors for new-onset atrial fibrillation in advanced lung cancer patients after non-surgical therapy [J]. Front Oncol, 2023, 13: 1125592. DOI: 10.3389/fonc.2023.1125592.
[6]	Sun K, Ren M, Liu D, et al. Alcohol consumption and risk of metabolic syndrome: a meta-analysis of prospective studies [J]. Clin Nutr, 2014, 33(4): 596-602. DOI: 10.1016/j.clnu.2013.10.003.
[7]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版) [J]. 中华糖尿病杂志, 2021, 13(4): 95. DOI: 10.3760/cma.j.cn115791-20210221-00095. Chinese Society of Diabetes. Guidelines for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition) [J]. Chin J Diabetes, 2021, 13(4): 95. DOI: 10.3760/cma.j.cn115791-20210221-00095.
[8]	中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版) [J]. 中国循环杂志, 2016, 31(10): 937-950. DOI: 10.3969/j.issn.1000-3614.2016.10.001. Joint Committee on Revision of Chinese Guidelines for Prevention and Treatment of Adult Dyslipidemia. Guidelines for prevention and treatment of dyslipidemia in adults in China (revised in 2016) [J]. Chin Circ J, 2016, 31(10): 937-950. DOI: 10.3969/j.issn.1000-3614.2016.10.001.
[9]	World Health Organization. MONICA project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators [J]. J Clin Epidemiol, 1988, 41(2): 105-114. DOI: 10.1016/0895-4356(88)90084-4.
[10]	Levey AS, Coresh J, Balk E, et al. National kidney foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification [J]. Ann Intern Med, 2003, 139(2): 137-147. DOI: 10.7326/0003-4819-139-2-200307150-00013.
[11]	徐培兰, 木日扎提·买买提, 孜克娅·乃吉木, 等. 新疆居民慢性病疾病谱现况调查及对策研究[J]. 卫生软科学, 2021, 35(2): 73-76. DOI: 10.3969/j.issn.1003-2800.2021.02.018. Xu PL, Murizhati MMT, Zikeya NJM, et al. Investigation on status quo of chronic disease spectrum of residentsin Xinjiang and its countermeasures [J]. Soft Science of Health, 2021, 35(2): 73-76. DOI: 10.3969/j.issn.1003-2800.2021.02.018.
[12]	刘少博. 10省市队列人群糖尿病前期与糖尿病发病状况及影响因素研究[D]. 北京: 中国疾病预防控制中心, 2020. Liu SB. Study on the incidence of prediabetes and diabetes and related factors based on a cohort population from 10 provinces in China [D]. Beijing: Chinese Center for Disease Control and Prevention, 2020.
[13]	汪慧, 薛振香, 利耀辉, 等. 新疆喀什地区维吾尔族成年居民糖尿病发病风险及影响因素[J]. 热带医学杂志, 2019, 19(10): 1288-1291. DOI: 10.3969/j.issn.1672-3619.2019.10.025. Wang H, Xue ZX, Li YH, et al. Ineidence and associated risk factors of diabetes mellitus among Uygur adult residents in Kashgar of South Xinjiang [J]. J Trop Med, 2019, 19(10): 1288-1291. DOI: 10.3969/j.issn.1672-3619.2019.10.025.
[14]	Bjørnholt JV, Erikssen G, Liestøl K, et al. Type 2 diabetes and maternal family history: an impact beyond slow glucose removal rate and fasting hyperglycemia in low-risk individuals? Results from 22.5 years of follow-up of healthy nondiabetic men [J]. Diabetes Care, 2000, 23(9): 1255-1259. DOI: 10.2337/diacare.23.9.1255.
[15]	Murakami T, Inagaki N, Kondoh H. Cellular senescence in diabetes mellitus: distinct senotherapeutic strategies for adipose tissue and pancreatic β cells [J]. Front Endocrinol, 2022, 13: 869414. DOI: 10.3389/fendo.2022.869414.
[16]	Bhatt PP, Sheth MS. Comparison of fatigue and functional status in elderly type 2 diabetes patients versus age and gender matched individuals [J]. Aging Med (Milton), 2024, 7(1): 84-89. DOI: 10.1002/agm2.12289.
[17]	李亚丽. 金昌队列人群糖尿病前瞻性研究及多重巢式病例对照研究[D]. 兰州: 兰州大学, 2018. Li YL. Prospective study on diabetes mellitus in Jinchang cohort and multi-nested case-control study [D]. Lanzhou: Lanzhou University, 2018.
[18]	Klein S, Gastaldelli A, Yki-Jrvinen H, et al. Why does obesity cause diabetes? [J]. Cell Metab, 2022, 34(1): 11-20. DOI: 10.1016/j.cmet.2021.12.012.
[19]	Perdomo CM, Cohen RV, Sumithran P, et al. Contemporary medical, device, and surgical therapies for obesity in adults [J]. Lancet, 2023, 401(10382): 1116-1130. DOI: 10.1016/S0140-6736(22)02403-5.
[20]	付朝伟. 农村社区成人2型糖尿病(德清队列)研究[D]. 上海: 复旦大学, 2010. Fu CW. Study on adult type 2 diabetes in rural community (Deqing cohort) [D]. Shanghai: Fudan University, 2010.
[21]	Bourke E, Maddison R, Blakely T. Getting the epidemiological associations of physical inactivity with diseases and injuries correct in comparative risk assessment [J]. Int J Epidemiol, 2023, 52(6): 1677-1680. DOI: 10.1093/ije/dyad107.
[22]	Wang Y, Gao J, Zhang L, et al. Bioinformatics analysis of lncRNA-related ceRNA networks in the peripheral blood lymphocytes of Kazakh patients with essential hypertension in Xinjiang [J]. Front Cardiovasc Med, 2023, 10: 1155767. DOI: 10.3389/fcvm.2023.1155767.
[23]	Tangvarasittichai S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus [J]. World J Diabetes, 2015, 6(3): 456-480. DOI: 10.4239/wjd.v6.i3.456.