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CN 34-1304/RISSN 1674-3679

Volume 28 Issue 12
Dec.  2024
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Article Contents
GUO Qisheng, YE Yongsheng, WANG Yangguang, SONG Jinling, GAO Meng, DAI Seying, ZHANG Jin, FAN Yinguang. Survival analysis of HIV/AIDS in Anhui among different AIDS diagnosis and treatment guidelines, 2006-2022[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(12): 1399-1405. doi: 10.16462/j.cnki.zhjbkz.2024.12.006
Citation: GUO Qisheng, YE Yongsheng, WANG Yangguang, SONG Jinling, GAO Meng, DAI Seying, ZHANG Jin, FAN Yinguang. Survival analysis of HIV/AIDS in Anhui among different AIDS diagnosis and treatment guidelines, 2006-2022[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(12): 1399-1405. doi: 10.16462/j.cnki.zhjbkz.2024.12.006

Survival analysis of HIV/AIDS in Anhui among different AIDS diagnosis and treatment guidelines, 2006-2022

doi: 10.16462/j.cnki.zhjbkz.2024.12.006
Funds:

Research Funds of Center for Big Data and Population Health of IHM JKS2022003

Project of Chinese Center for Disease Control and Prevention 2022-CG-Room of Hepatitis C and Sexually Transmitted Diseases Prevention and Control-024

More Information
  • Corresponding author: ZHANG Jin, E-mail : zhangjin@ahcdc.com.cn; FAN Yinguang, E-mail : fanyinguang@163.com
  • Received Date: 2024-09-26
  • Rev Recd Date: 2024-11-18
  • Available Online: 2025-01-24
  • Publish Date: 2024-12-10
  •   Objective  This study aims to compare the survival rates of HIV infected and AIDS patients (HIV/AIDS) in Anhui Province under different versions of Guidelines for Diagnosis and Treatment of AIDS, and explore the factors influencing survival time.  Methods  Based on a retrospective cohort study of HIV/AIDS in Anhui Province from 2006 to 2022, the study period was divided into five phases according to the publication dates of the Guidelines. The Life-table method and Cox proportional hazards model were used to analyze survival rates and factors influencing survival time.  Results  A total of 25 334 participants were included, of whom 83.51% were male, 68.76% were aged of diagnosis > 30- < 60 years, and 49.70% resided in northern Anhui Province. The one-year survival rates across the five periods (95%, 95%, 97%, 97%, and 96%) showed significant differences (χ2 =46.180, P < 0.001). Similarly, the two-year survival rates for the first four periods (93%, 94%, 95%, and 95%) also exhibited significant differences (χ2 =17.103, P < 0.001). Cox proportional hazards regression analysis revealed the following factors influencing HIV/AIDS mortality risk, females had 0.654 times lower risk than males (95% CI : 0.588-0.727, P < 0.001). Individuals aged over 60 years had 4.665 times higher risk compared to younger individuals (95% CI: 3.930-5.539, P < 0.001). Unmarried individuals had 1.555 times higher risk than married individuals (95% CI : 1.382-1.750, P < 0.001). Those with education above primary school had 0.756 times lower risk compared to those with primary education (95% CI: 0.688-0.831, P0.001). Homosexual transmission was associated with 0.586 times lower risk than heterosexual transmission (95% CI: 0.524-0.656, P < 0.001). Additionally, higher CD4+ T lymphocyte (CD4) counts were associated with 0.385 times lower risk compared to lower counts (95% CI: 0.329-0.451, P < 0.001).  Conclusions  With the updates to China′s Guidelines, the survival rate of HIV/AIDS has shown an upward trend.
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  • [1]
    Li Y, Zhang XW, Liao B, et al. Social support status and associated factors among people living with HIV/AIDS in Kunming city, China [J]. BMC Public Health, 2021, 21(1): 1413. DOI: 10.1186/s12889-021-11253-2.
    [2]
    Wang CW, Chan CLW, Ho RTH. HIV/AIDS-related deaths in China, 2000-2012 [J]. AIDS Care, 2015, 27(7): 849-854. DOI: 10.1080/09540121.2015.1005568.
    [3]
    Zhang D, Wu JJ, Zhang Y, et al. Genetic characterization of HIV-1 epidemic in Anhui Province, China [J]. Virol J, 2020, 17(1): 17. DOI: 10.1186/s12985-020-1281-y.
    [4]
    Zhang FJ, Dou ZH, Ma Y, et al. Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study [J]. Lancet Infect Dis, 2011, 11(7): 516-524. DOI: 10.1016/S1473-3099(11)70097-4.
    [5]
    World Health Organization (WHO). Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV [EB/OL]. (2015-09-01)[2024-09-26]. https://www.who.int/publications/i/item/9789241509565.
    [6]
    戴色莺, 刘爱文, 沈月兰, 等. 安徽省接受抗病毒治疗HIV/AIDS死亡的影响因素[J]. 中华疾病控制杂志, 2022, 26(12): 1379-1383, 1401. DOI: 10.16462/j.cnki.zhjbkz.2022.12.003.

    Dai SY, Liu AW, Shen YL, et al. Influencing factors on the death of HIV/AIDS patients receiving antiretroviral therapy in Anhui Province [J]. Chin J Dis Control Prev, 2022, 26(12): 1379-1383, 1401. DOI: 10.16462/j.cnki.zhjbkz.2022.12.003.
    [7]
    中华医学会感染病学分会艾滋病学组制订. 艾滋病诊疗指南[J]. 中华传染病杂志, 2006, 24(2): 133-144. DOI: 10.3760/j.issn:1000-6680.2006.02.021.

    AIDS Working Group of the Society of Infectious Diseases, Chinese Medical Association. AIDS diagnosis and treatment guide [J]. Chin J Infect Dis, 2006, 24(2): 133-144. DOI: 10.3760/j.issn:1000-6680.2006.02.021.
    [8]
    Ke SS, Fang Q, Lan JG, et al. Survival times of HIV/AIDS in different AIDS diagnostic and treatment guidelines from 2006 to 2020 in Liuzhou, China [J]. BMC Public Health, 2023, 23(1): 1745. DOI: 10.1186/s12889-023-15662-3.
    [9]
    孙建军, 卢洪洲. 《艾滋病诊疗指南第三版(2015版)》更新解读[J]. 浙江大学学报(医学版), 2015, 44(6): 597-602. DOI: 10.3785/j.issn.1008-9292.2015.11.01.

    Sun JJ, Lu HZ. Highlights of the third edition of Chinese guidelines for AIDS diagnosis and treatment (2015) [J]. J Zhejiang Univ Med Sci, 2015, 44(6): 597-602. DOI: 10.3785/j.issn.1008-9292.2015.11.01.
    [10]
    中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心. 中国艾滋病诊疗指南(2018年版) [J]. 中华内科杂志, 2018, 57(12): 867-884. DOI: 10.3760/cma.j.issn.0578-1426.2018.12.002.

    AIDS and Hepatitis C Professional Group Society of Infectious Diseases, Chinese Center for Disease Control and Prevention. Chinese guidelines for diagnosis and treatment of HIV/AIDS (2018) [J]. Chin J Intern Med, 2018, 57(12): 867-884. DOI: 10.3760/cma.j.issn.0578-1426.2018.12.002.
    [11]
    中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心. 中国艾滋病诊疗指南(2021年版) [J]. 中华内科杂志, 2021, 60(12): 1106-1128. DOI: 10.3760/cma.j.cn112138-20211006-00676.

    AIDS and Hepatitis C Professional Group Society of Infectious Diseases, Chinese Center for Disease Control and Prevention. Chinese guidelines for diagnosis and treatment of HIV/AIDS (2021 edition) [J]. Chin J Intern Med, 2021, 60(12): 1106-1128. DOI: 10.3760/cma.j.cn112138-20211006-00676.
    [12]
    Zhao Y, Wei L, Dou ZH, et al. Changing mortality and patterns of death causes in HIV infected patients - China, 2013-2022 [J]. China CDC Wkly, 2023, 5(48): 1073-1078. DOI: 10.46234/ccdcw2023.201.
    [13]
    金怡晨, 秦倩倩, 蔡畅, 等. 中国2011―2020年新报告HIV/AIDS短期内死亡特征及风险因素[J]. 中华疾病控制杂志, 2023, 27(6): 673-677. DOI: 10.16462/j.cnki.zhjbkz.2023.06.010.

    Jin YC, Qin QQ, Cai C, et al. Characteristics and risk factors of early death among newly diagnosed HIV/AIDS in China, 2011-2020 [J]. Chin J Dis Control Prev, 2023, 27(6): 673-677. DOI: 10.16462/j.cnki.zhjbkz.2023.06.010.
    [14]
    Mao NL, Pan HF, Lu MM, et al. AIDS awareness and condom use among patients in a high-HIV-prevalence area in rural northern Anhui, China [J]. J Investig Med, 2010, 58(6): 801-803. DOI: 10.231/JIM.0b013e3181e80188.
    [15]
    范引光, 朱志伟, 马炜祥, 等. 安徽省阜阳市HIV/HCV共感染者抗病毒治疗服药依从性及影响因素分析[J]. 中华疾病控制杂志, 2017, 21(12): 1204-1208. DOI: 10.16462/j.cnki.zhjbkz.2017.12.005.

    Fan YG, Zhu ZW, Ma WX, et al. Study on influencial factors of adherence to anti-retroviral treatment among people who co-infected with HIV/HCV in Fuyang City, Anhui Province [J]. Chin J Dis Control Prev, 2017, 21(12): 1204-1208. DOI: 10.16462/j.cnki.zhjbkz.2017.12.005.
    [16]
    Zheng ZG, Nehl EJ, Zhou CX, et al. Insufficient tuberculosis treatment leads to earlier and higher mortality in individuals co-infected with HIV in Southern China: a cohort study [J]. BMC Infect Dis, 2020, 20(1): 873. DOI: 10.1186/s12879-020-05527-0.
    [17]
    Hunt PW, Lee SA, Siedner MJ. Immunologic biomarkers, morbidity, and mortality in treated HIV infection [J]. J Infect Dis, 2016, 214(Suppl 2): S44-S50. DOI: 10.1093/infdis/jiw275.
    [18]
    Kim YC, Ahn JY, Kim HY, et al. Survival trend of HIV/AIDS patients starting antiretroviral therapy in South Korea between 2001 and 2015 [J]. Yonsei Med J, 2020, 61(8): 705-711. DOI: 10.3349/ymj.2020.61.8.705.
    [19]
    周超, 陈宗良, 吴国辉, 等. 2014―2018年重庆市中老年艾滋病抗病毒治疗患者生存状况分析[J]. 预防医学情报杂志, 2019, 35(12): 1379-1383.

    Zhou C, Chen ZL, Wu GH, et al. Analysis of the survival conditions and associated factors of middle-aged and older hiv/aids patients receiving antiretroviral therapy in Chongqing city from 2014 to 2018 [J]. J Prev Med Inf, 2019, 35(12): 1379-1383.
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