Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals

ZHANG Yunqiu; HAN Lei; SHI Luqian; QIAO Xiaotong; GAO Meiyang; DING Yingying

doi:10.16462/j.cnki.zhjbkz.2024.12.007

Volume 28 Issue 12

Dec. 2024

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(12): 1406-1413

ZHANG Yunqiu, HAN Lei, SHI Luqian, QIAO Xiaotong, GAO Meiyang, DING Yingying. Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(12): 1406-1413. doi: 10.16462/j.cnki.zhjbkz.2024.12.007

Citation:

ZHANG Yunqiu, HAN Lei, SHI Luqian, QIAO Xiaotong, GAO Meiyang, DING Yingying. Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(12): 1406-1413. doi: 10.16462/j.cnki.zhjbkz.2024.12.007

Citation:

ZHANG Yunqiu, HAN Lei, SHI Luqian, QIAO Xiaotong, GAO Meiyang, DING Yingying. Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(12): 1406-1413. doi: 10.16462/j.cnki.zhjbkz.2024.12.007

PDF( 2340 KB)

Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals

doi: 10.16462/j.cnki.zhjbkz.2024.12.007

1.
Department of Epidemiology, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China
2.
Jing′an District Center for Disease Control and Prevention, Chronic Infectious Disease Prevention and Control Department, Shanghai 200072, China

Funds:

Shanghai Natural Science Foundation 21ZR1403800

Health Science and Technology of Pudong New Area Health Commission of Shanghai PW2020-10A

More Information

Corresponding author: DING Yingying, E-mail: dingyy@fudan.edu.cn
Received Date: 2024-02-21
Rev Recd Date: 2024-10-16

Available Online: 2025-01-24

Publish Date: 2024-12-10

Abstract

Abstract

Objective To analyze the association of depressive symptoms with autonomic nervous system (ANS) function among human immunodeficiency virus (HIV) positive individuals. Methods This was a cross-sectional study between January and December 2023. HIV-positive individuals were recruited using convenient sampling. The composite autonomic symptom scale 31 composite autonomic symptom score (COMPASS-31) questionnaire was used to evaluate the autonomic nervous function symptom. A linear regression model was used to analyze the associated factors of COMPASS-31 scores among HIV-positive individuals, with adjustment for potential confounding factors, and stratification by different age groups. Results In total, 311 HIV-positive individuals were included. The average age was (42.0±14.0) years. The average COMPASS-31 total score was 8.1 (3.9, 14.8) points. The total score, vasomotor scores and gastrointestinal scores were higher, while Bladder scores were comparatively lower among HIV-positive individuals under 45 years. Multivariable linear regression results showed that age, waist-to-hip ratio (WHR) and maximum hand grip were negatively correlated with COMPASS-31 score, while insomnia symptoms and sleep duration of less than 6 hours were positively correlated with COMPASS-31 score. After further adjustment of depressive symptom score (β=-0.07, 95% CI: -0.14-0.00, P=0.045; β=-2.84, 95% CI: -4.73--0.95, P=0.004; β=-0.14, 95% CI: -0.25--0.02, P=0.020), age, high WHR and maximum hand grip were negatively correlated with COMPASS-31score (β=0.070, 95% CI: 0.42-0.97, P < 0.001), while depressive symptom score were positively correlated with COMPASS-31 score (β=-3.56, 95% CI: -6.07--1.05, P=0.006; β=-0.20, 95% CI: -0.36--0.04, P=0.014). Further stratified analysis by age groups revealed that among HIV-positive individuals under 45 years old, higher WHR and maximum hand grip were negatively correlated with COMPASS-31 scores. Additionally, positive correlations between COMPASS-31 scores and CD4 cell count >500 cells/μL, as well as depressive symptom scores, were observed exclusively in this young age group (β=3.51, 95% CI: 0.89-6.14, P=0.010; β=0.79, 95% CI: 0.44-1.14, P < 0.001). Conclusions Depression can aggravate the severity of autonomic nervous dysfunction symptoms in HIV-positive individuals, appropriate health guidance should be provided in response.
- Human immunodeficiency virus,
- Depressive symptoms,
- Autonomic nervous system function

FullText(HTML)

References(24)

References

[1]	McIntosh RC. A Meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy[J]. Clin Auton Res, 2016, 26(4): 287-294. DOI: 10.1007/s10286-016-0366-6.
[2]	Robinson-Papp J, Nmashie A, Pedowitz E, et al. Vagal dysfunction and small intestinal bacterial overgrowth: novel pathways to chronic inflammation in HIV[J]. AIDS, 2018, 32(9): 1147-1156. DOI: 10.1097/QAD.0000000000001802.
[3]	Pence BW, Mills JC, Bengtson AM, et al. Association of increased chronicity of depression with HIV appointment attendance, treatment failure, and mortality among HIV-infected adults in the United States[J]. JAMA Psychiatry, 2018, 75(4): 379-385. DOI: 10.1001/jamapsychiatry.2017.4726.
[4]	Vaccarino V, Badimon L, Bremner JD, et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation[J]. Eur Heart J, 2020, 41(17): 1687-1696. DOI: 10.1093/eurheartj/ehy913.
[5]	Schrock JM. Accelerated aging in people living with HIV: the neuroimmune feedback model[J]. Brain Behav Immunity Health, 2024, 36: 100737. DOI: 10.1016/j.bbih.2024.100737.
[6]	Mudra Rakshasa-Loots A, Whalley HC, Vera JH, et al. Neuroinflammation in HIV-associated depression: evidence and future perspectives[J]. Mol Psychiatry, 2022, 27(9): 3619-3632. DOI: 10.1038/s41380-022-01619-2.
[7]	Sletten DM, Suarez GA, Low PA, et al. COMPASS 31: a refined and abbreviated composite autonomic symptom score[J]. Mayo Clin Proc, 2012, 87(12): 1196-1201. DOI: 10.1016/j.mayocp.2012.10.013.
[8]	D'Ippolito I, Menduni M, D'Amato C, et al. Does the relationship of the autonomic symptoms questionnaire COMPASS 31 with cardiovascular autonomic tests differ between type 1 and type 2 diabetes mellitus?[J]. Diabetes Metab J, 2024, 48(6): 1114-1125. DOI: 10.4093/dmj.2023.0301.
[9]	Jenkins CD, Stanton BA, Niemcryk SJ, et al. A scale for the estimation of sleep problems in clinical research[J]. J Clin Epidemiol, 1988, 41(4): 313-321. DOI: 10.1016/0895-4356(88)90138-2.
[10]	Zung WW. A self-rating depression scale[J]. Arch Gen Psychiatry, 1965, 12: 63-70. DOI: 10.1001/archpsyc.1965.01720310065008.
[11]	Sacktor NC, Wong M, Nakasujja N, et al. The international HIV dementia scale: a new rapid screening test for HIV dementia[J]. AIDS, 2005, 19(13): 1367-1374.
[12]	Da Silva H, Pardaens S, Vanderheyden M, et al. Autonomic symptoms and associated factors in patients with chronic heart failure[J]. Acta Cardiol, 2023, 78(2): 203-211. DOI: 10.1080/00015385.2021.2010953.
[13]	Martinez J, Palma JA, Norcliffe-Kaufmann L, et al. Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials[J]. Clin Auton Res, 2020, 30(3): 215-221. DOI: 10.1007/s10286-020-00681-6.
[14]	Won E, Kim YK. Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression[J]. Curr Neuropharmacol, 2016, 14(7): 665-673. DOI: 10.2174/1570159x14666151208113006.
[15]	Jarrett ME, Burr RL, Cain KC, et al. Anxiety and depression are related to autonomic nervous system function in women with irritable bowel syndrome[J]. Dig Dis Sci, 2003, 48(2): 386-394. DOI: 10.1023/a:1021904216312.
[16]	Vgontzas AN, Liao DP, Pejovic S, et al. Insomnia with objective short sleep duration is associated with type 2 diabetes: a population-based study[J]. Diabetes Care, 2009, 32(11): 1980-1985. DOI: 10.2337/dc09-0284.
[17]	Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and Meta-analysis of cohort studies and experimental sleep deprivation[J]. Biol Psychiatry, 2016, 80(1): 40-52. DOI: 10.1016/j.biopsych.2015.05.014.
[18]	Alen NV, Parenteau AM, Sloan RP, et al. Heart rate variability and circulating inflammatory markers in midlife[J]. Brain Behav Immun Health, 2021, 15: 100273. DOI: 10.1016/j.bbih.2021.100273.
[19]	Irwin MR, Archer G, Olmstead R, et al. Increased risk of depression in non-depressed HIV infected men with sleep disturbance: prospective findings from the multicenter AIDS cohort study[J]. EBioMedicine, 2018, 36: 454-460. DOI: 10.1016/j.ebiom.2018.09.028.
[20]	Lavín-Pérez AM, Collado-Mateo D, Hinojo González C, et al. High-intensity exercise prescription guided by heart rate variability in breast cancer patients: a study protocol for a randomized controlled trial[J]. BMC Sports Sci Med Rehabil, 2023, 15(1): 28. DOI: 10.1186/s13102-023-00634-2.
[21]	Quevedo-Jerez K, Gil-Rey E, Maldonado-Martín S, et al. Exercise-intensity adherence during aerobic training and cardiovascular response during resistance training in cancer survivors[J]. J Strength Cond Res, 2021, 35(8): 2338-2345. DOI: 10.1519/JSC.0000000000003144.
[22]	Yadav RL, Yadav PK, Yadav LK, et al. Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration - a risk of CVD[J]. Diabetes Metab Syndr Obes, 2017, 10: 57-64. DOI: 10.2147/DMSO.S123935.
[23]	Compostella C, Compostella L, D'Elia R. The symptoms of autonomic dysfunction in HIV-positive Africans[J]. Clin Auton Res, 2008, 18(1): 6-12. DOI: 10.1007/s10286-007-0451-y.
[24]	Benvenuto LJ, Krakoff LR. Morbidity and mortality of orthostatic hypotension: implications for management of cardiovascular disease[J]. Am J Hypertens, 2011, 24(2): 135-144. DOI: 10.1038/ajh.2010.146.