A cross-sectional study on the association between blood inflammation-related indicators and gastric cancer in middle-aged and elderly people in Wuxi

SHEN Fang; ZHU Xia; LIU Jia; ZHU Meng; WANG Lu; JIN Guangfu

doi:10.16462/j.cnki.zhjbkz.2025.04.010

Volume 29 Issue 4

Apr. 2025

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SHEN Fang, ZHU Xia, LIU Jia, ZHU Meng, WANG Lu, JIN Guangfu. A cross-sectional study on the association between blood inflammation-related indicators and gastric cancer in middle-aged and elderly people in Wuxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 437-442. doi: 10.16462/j.cnki.zhjbkz.2025.04.010

Citation:

SHEN Fang, ZHU Xia, LIU Jia, ZHU Meng, WANG Lu, JIN Guangfu. A cross-sectional study on the association between blood inflammation-related indicators and gastric cancer in middle-aged and elderly people in Wuxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 437-442. doi: 10.16462/j.cnki.zhjbkz.2025.04.010

Citation:

SHEN Fang, ZHU Xia, LIU Jia, ZHU Meng, WANG Lu, JIN Guangfu. A cross-sectional study on the association between blood inflammation-related indicators and gastric cancer in middle-aged and elderly people in Wuxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 437-442. doi: 10.16462/j.cnki.zhjbkz.2025.04.010

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A cross-sectional study on the association between blood inflammation-related indicators and gastric cancer in middle-aged and elderly people in Wuxi

doi: 10.16462/j.cnki.zhjbkz.2025.04.010

SHEN Fang¹,
ZHU Xia¹,
LIU Jia²,
ZHU Meng¹,
WANG Lu²,
JIN Guangfu^{1
,
,}

1.
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
Department of Chronic Non-Communicable Disease, Wuxi Center for Disease Control and Prevention (Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University), Wuxi 214023, China

Funds:

National Natural Science Foundation of China 82230110

More Information

Corresponding author: JIN Guangfu, E-mail: guangfujin@njmu.edu.cn
Received Date: 2024-06-25
Rev Recd Date: 2024-10-15
Publish Date: 2025-04-10

Abstract

Abstract

Objective To investigate whether blood inflammation-related indicators are correlated with the prevalence of gastric cancer. Methods Questionnaire information and blood routine test data were collected at baseline from participants aged 45 years and older in the Taihu biobank of tumour biomarkers (TBTB) from 2020 to 2021. The correlation between blood inflammation-related indicators, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), derived neutrophil-to-lymphocyte ratio (dNLR), and neutrophil-to-lymphocyte and platelet ratio (NLPR), and the prevalence as well as the course of gastric cancer were analyzed using multiple linear regression within a cross-sectional study design. Results A total of 284 886 subjects were included in this study, including 1 920 gastric cancer cases. Compared with non-gastric cancer patients, gastric cancer patients had lower levels of NLR (β=-0.09, 95% CI: -0.14--0.04), SII (β=-0.13, 95% CI: -0.18--0.09) and dNLR (β=-0.07, 95% CI: -0.12--0.03), while gastric cancer patients have higher levels of PLR (β=0.10, 95% CI: 0.06-0.15). In addition, the levels of NLR (β=0.185, 95% CI: 0.098-0.273), PLR (β=0.243, 95% CI: 0.151-0.335), SII (β=0.207, 95% CI: 0.116-0.298), dNLR (β=0.156, 95% CI: 0.071-0.242) and NLPR (β=0.093, 95% CI: 0.004-0.182) all increased with the prolongation of the gastric cancer course. Conclusions In middle-aged and elderly people of Wuxi, the blood inflammation levels of gastric cancer patients are generally lower than those of non-gastric cancer patients. Moreover, as the course of gastric cancer progresses, there is an increase in blood inflammation-related indicators among gastric cancer patients.
- Inflammation- related indicator,
- Gastric cancer,
- Cross-sectional study

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References(13)

References

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