Study on transition levels of maternal neutralizing antibodies against enterovirus 71 and coxsackievirus A16 in infants in Guangzhou
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摘要: 目的 了解新生儿及其母亲肠道病毒71型（enterovirus 71，EV71）和柯萨奇病毒A组16型（coxsackievirus A16，CoxA16）中和抗体水平，为建立疫苗免疫程序提供科学依据。方法 征集2013年7月～2014年4月在广州市荔湾区妇幼保健院进行分娩并经知情同意的产妇及其新生儿作为研究对象，共纳入181对母亲和新生儿。采用微量细胞病变抑制法检测EV71和CoxA16中和抗体，运用血清流行病学方法进行母传抗体消长特征研究。结果 在纳入的181对母亲和新生儿中，母亲EV71和CoxA16中和抗体阳性率分别为83.98%和88.95%，几何平均滴度倒数（geometric mean reciprocal titer,GMRT）分别为25.42和27.00。新生儿EV71和CoxA16中和抗体阳性率分别为74.03%和71.82%，GMRT分别为20.50和16.48。新生儿的EV71和CoxA16中和抗体滴度与其母亲的EV71和CoxA16中和抗体滴度均呈正相关（rEV71=0.70，P<0.001；rCoxA16=0.75，P<0.001）。0～6月龄婴儿体内EV71和CoxA16中和抗体随月龄增加均呈下降趋势（χEV712=100.23，P<0.001；χCoxA162=112.24，P<0.001）。结论 建议手足口病灭活疫苗在6月龄接种为宜，育龄期妇女接种手足口病疫苗能提高婴儿体内抗体水平，以降低小于6月龄婴儿发病率。Abstract: Objective To explore the transition levels of maternal neutralizing antibodies against enterovirus 71 (EV71) and coxsackievirus A16(CoxA16) in infants in Guangzhou, and to provide the scientific evidence for establishing corresponding immunization course.Methods Prenatal women who took a delivery in Liwan Maternal and Child Health Hospital from July 2013 to April 2014 and their infants were included in the study.Method of micro-dose cytopathogenic effect was used to measure neutralizing antibodies against EV71 and CoxA16, respectively. Seroepidemiological analysis was also conducted.Results The mothers' seropositive rates and geometric mean reciprocal titers(GMRTs) of EV71 and CoxA16 antibodies were 83.98%, 88.95% and 25.42, 27.00, respectively; the newborns' seropositive rates and GMRTs of EV71 and CoxA16 antibodies were 74.03%, 71.82% and 20.50, 16.48, respectively. The EV71 and CoxA16 antibody titers of newborns were positively associated with those of mothers(rEV71=0.70,P<0.001;rCoxA16=0.75,P<0.001), which decreased with the increased ages (χEV712=100.23,P<0.001;χCoxA162=112.24,P<0.001).Conclusions The vaccine should be vaccinated in 6 months of age. It is suggested that the women of childbearing age should be inoculated with hand, foot and mouth disease vaccine to reduce the incidence rate of infants who are under 6 months of age.
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Key words:
- Hand-foot-mouth disease /
- Infant /
- Seroepidemiologic studies
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