The prognostic and predictive value of serum CA199 and CEA in colorectal cancer metastasis
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摘要: 目的 探讨血清肿瘤标记物糖类抗原199（carbohydrate antigen 199，CA199）、癌胚抗原（carcinoembryonic antigen，CEA）对结直肠癌转移和预后预测的价值。方法 收集1 064例结直肠癌手术患者的临床资料，测定血清CA199和CEA并对预后进行随访，用受试者工作特征（receiver operating characteristics，ROC）曲线和生存分析法分析血清CA199、CEA对肝脏转移和淋巴结转移预测价值以及与预后的关系。结果 血清CEA和CA199分别对肝脏和淋巴结转移有一定的筛选价值。CA199、CEA表达单阳或双阳的平均生存时间明显缩短（均有P<0.05），Cox比例风险回归分析显示血清CEA浓度阳性的死亡风险是阴性的1.50倍（HR=1.50，95%CI：0.89~1.83，P=0.020）。结论 血清CA199、CEA浓度升高是结直肠癌预后的危险因素，且对结直肠癌的相关临床病理转移有一定的预测价值。
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关键词:
- 结直肠肿瘤 /
- 抗原，肿瘤相关，碳水化合物 /
- 癌胚抗原
Abstract: Objective To determine the prognostic and predictive value of serum CA199 and CEA in colorectal cancer metastasis. Methods Clinical characteristics of 1 064 patients with colorectal cancer were collected. Serum CA199 and CEA were tested. All participants were followed-up in term of prognosis. Results CA199 exhibited higher predictive accuracy index for predicting lymph node metastasis, whereas serum CEA was more accurate for the prediction of liver metastasis. Patients with negative levels of CA199/CEA had significantly prolonged survival than those with either single positive CA199/CEA or double positive indicators (all P<0.05). Cox proportional hazards regression showed that the risk of death from positive serum CEA was 1.50 times of that from negative group (HR=1.50, 95% CI:0.89-1.83, P=0.020). Conclusions Serum CA199 and CEA levels are risk factors of poor prognosis in colorectal cancer patients, which may be utilized to predict metastasis. -
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