-
摘要: 尼帕病毒(Nipah virus,NIV)于1998年在马来西亚首次被发现,2001年以来在孟加拉国和印度长期流行。在马来西亚和新加坡,NIV主要通过接触病猪传播,而在孟加拉国和印度主要是通过食用生椰枣汁和人传人来传播。NIV感染的危险因素主要包括接触病死猪、食用生椰枣汁和接触患者。目前,还没有疫苗或有效的抗病毒药物来预防和治疗NIV感染。预防措施主要包括避免接触受感染的患者或宿主动物、不食用生椰枣汁,以及照顾病人时加强防护、消毒和勤洗手。同时,要加强重点地区的疾病监测,力争早发现早处置暴发疫情。Abstract: Nipah virus (NIV) emerged in Malaysia in 1998 and subsequently occurred in Bang-ladesh and India since 2001. In the Malaysia-Singapore outbreak, transmission occurred primarily through contacting with pigs, whereas in Bangladesh and India, it was associated with ingestion of contaminated date palm sap and human-to-human transmission. Risk factors of NIV infection mainly included close contacting with ill pigs, consuming raw date palm sap, and contacting with Nipah cases. At present, no vaccines or antiviral drugs are available for NIV disease and the treatment is just supportive. Nipah virus infections can be prevented by avoiding direct contact with infected patients and host organisms, avoiding of ingestion of date palm sap, frequent hand washing and sanitization while caring for NIV patients. Surveillance for NIV in humans and reservoir animals should be done in affected areas, which helps in detecting early signs of NIV outbreak.
-
Key words:
- Nipah Viru /
- Qutbreak /
- Risk factors /
- Epidemiology
-
[1] Brenda SP, Tchoyoson CC, Wang L. Nipah virus infection[J]. J Clin Microbiol, 2018, 56(6):e01875-17. DOI: 10.1128/JCM.01875-17. [2] Li K, Yan S, Wang N, et al. Emergence and adaptive evolution of Nipah virus[J]. Transbound Emerg Dis, 2020, 67(1):121-132. DOI: 10.1111/tbed.13330. [3] 辛化雷, 薛爱丽, 梁纪伟, 等. 1998-2018年全球尼帕病毒感染流行特征及危险因素分析[J].疾病监测, 2019, 34(1):89-92. DOI: 10.3784/j.issn.1003-9961.2019.01.021.Xin HL, Xue AL, Liang JW, et al. Global epidemiology and risk factors of Nipah virus infection in human, 1998-2018[J]. Dis Surveilance, 2019, 34(1):89-92. DOI: 10.3784/j.issn.1003-9961.2019.01.021. [4] 李国华, 王化磊, 张颖, 等.尼帕病毒病的流行现状与防治研究进展[J].传染病信息, 2018, 31(5):425-442. DOI: 10.3969/j.issn.1007-8134.2018.05.005.Li GH, Wang HL, Zhang Y, et al. Current epidemiology and progress in prevention-treatment of Nipah virus disease[J]. Infectious Disease Inf, 2018, 31(5):425-442. DOI: 10.3969/j.issn.1007-8134.2018.05.005. [5] Plowright RK, Becker DJ, Crowley DE, et al. Prioritizing surveillance of Nipah virus in India[J]. PLoS Negl Trop Dis, 2019, 13(6):e0007393. DOI: 10.1371/journal.pntd.0007393. [6] Aishwarya SA, Sabah MZ, Neha P, et al. Nipah virus: a review on epidemiological characteristics and outbreaks to inform public health decision making[J]. J Infect Public Health. 2019, 12(5):634-639. DOI: 10.1016/j.jiph.2019.02.013. [7] Chua KB. Risk factors, prevention and communication strategy during Nipah virus outbreak in Malaysia[J]. Malays J Pathol, 2010, 32(2):75-80. http://www.ncbi.nlm.nih.gov/pubmed/21329177 [8] Chattu VK, Kumar R, Kumary S, et al. Nipah virus epidemic in southern India and emphasizing "One Health" approach to ensure global health security[J]. J Family Med Prim Care, 2018, 7(2):275-83. DOI: 10.4103/jfmpc.jfmpc_137_18. [9] Micah BH, Jonathan HE, Emily S. Roosting behaviour and habitat selection of Pteropus giganteus reveals potential links to Nipah virus epidemiology[J]. J Appl Ecol, 2014, 51(2):376-387. DOI: 10.1111/1365-2664.12212. [10] Fagre AC, Kading RC. Can bats serve as reservoirs for arboviruses?[J]. Viruses, 2019, 11(3):215. DOI: 10.3390/v11030215. [11] Parashar UD, Sunn LM, Ong F, et al. Case-control study of risk factors for human infection with a new zoonotic paramyxovirus, Nipah virus, during a 1998-1999 outbreak of severe encephalitis in Malaysia[J]. J Infect Dis, 2000, 181(5):1755-1759. DOI: 10.1086/315457 [12] Madeleine HLC, Arguin PM, Shay DK, et al. Risk factors for Nipah virus infection among abattoir workers in Singapore[J]. J Infect Dis, 2000, 181(5):1760-1763. DOI: 10.1086/315443. [13] Anthony WM, Hanjeet K, Umesh DP. A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999[J]. J Infect Dis, 2001, 183(5):810-813. DOI: 10.1086/318822. [14] Hsu VP, Hossain MJ, Parashar UD, et al. Nipah virus encephalitis reemergence, Bangladesh[J]. Emerg Infect Dis, 2004, 10(12):2282-2287. DOI: 10.3201/eid1012.040701. [15] Montgomery JM, Hossain MJ, Gurley E, et al. Risk factors for Nipah virus encephalitis in Bangladesh[J]. Emerg Infect Dis, 2008, 14(10):1526-1531. DOI: 10.3201/eid1410.060507. [16] Stephen PL, Mahmudur R, Jahangir H, et al. Foodborne transmission of Nipah virus, Bangladesh[J]. Emerg Infect Dis, 2006, 12(12):1888-1894. DOI: 10.1007/s10393-016-1166-0. [17] Muhammad AR, Mohammad JH, Sharmin S, et al. Date palm sap linked to Nipah virus outbreak in Bangladesh, 2008[J]. Vector borne Zoonotic Dis, 2012, 12(1):65-72. DOI: 10.1089/vbz.2011.0656. [18] Sazzad HM, Hossain MJ, Gurley ES, et al. Nipah virus infection outbreak with nosocomial and corpse-to-human transmission, Bangladesh[J]. Emerg Infect Dis, 2013, 19(2):210-217. DOI: 10.3201/eid1902.120971. [19] Emily SG, Sonia TH, Kamal H, et al. Convergence of humans, bats, trees, and culture in Nipah virus transmission, Bangladesh[J]. Emerg Infect Dis, 2017, 23(9):1446-1453. DOI: 10.3201/eid2309.161922. [20] Hossain MZ, Sazzad HM, Luby SP, et al. Nipah virus contamination of hospital surfaces during outbreaks, Bangladesh, 2013-2014[J]. Emerg Infect Dis, 2018, 24(1):15-21. DOI: 10.3201/eid2401.161758. [21] Sonia TH, Hossain MS, Jahangir H, et al. Investigating rare risk factors for Nipah virus in Bangladesh: 2001-2012[J]. Ecohealth, 2016, 13(4):720-728. DOI: 10.1007/s10393-016-1166-0. [22] Nahar N, Paul RC, Sultana R, al et. Raw sap consumption habits and its association with knowledge of Nipah virus in two endemic districts in Bangladesh[J]. PLoS One, 2015, 10(11):e0142292. DOI: 10.1371/journal.pone.0142292. [23] Nazmun N, Repon CP, Rebeca S, et al. A controlled trial to reduce the risk of human Nipah virus exposure in Bangladesh[J]. Ecohealth, 2017, 14(3):501-517. DOI: 10.1007/s10393-017-1267-4. [24] Lam SK, Chua KB. Nipah virus encephalitis outbreak in Malaysia[J]. Clin Infect Dis, 2002, 34(Suppl 2):S48-51. DOI: 10.1086/338818. [25] Arunkumar G, Chandni R, Mourya DT, et al. Outbreak investigation of Nipah virus disease in Kerala, India, 2018[J]. J Infect Dis, 2019, 219(12):1867-1878. DOI: 10.1093/infdis/jiy612. [26] Nusrat H, Mahmudur R, Jahangir H, et al. Cluster of Nipah virus infection, Kushtia district, Bangladesh, 2007[J]. PLoS One, 2010, 5(1):e13570. DOI: 10.1371/journal.pone.0013570.
点击查看大图
计量
- 文章访问数: 678
- HTML全文浏览量: 382
- PDF下载量: 72
- 被引次数: 0