内蒙古心血管病高危人群饮酒模式与健康相关生活质量的关系

曹宁; 席云峰; 牛丽薇; 张楠; 包含; 朱浩; 闫涛; 张星光

doi:10.16462/j.cnki.zhjbkz.2022.04.007

内蒙古心血管病高危人群饮酒模式与健康相关生活质量的关系

doi: 10.16462/j.cnki.zhjbkz.2022.04.007

曹宁¹,
席云峰²,
牛丽薇³,
张楠⁴,
包含⁵,
朱浩⁵,
闫涛⁵,
张星光^5, ,

1.
010110 呼和浩特，内蒙古医科大学公共卫生学院流行病学教研室
2.
010031 呼和浩特，内蒙古综合疾病预防控制中心地方病与慢性非传染性疾病预防控制研究所
3.
010110 呼和浩特，内蒙古医科大学公共卫生学院儿童少年卫生教研室
4.
010110 呼和浩特，内蒙古医科大学公共卫生学院毒理学教研室
5.
010110 呼和浩特，内蒙古医科大学公共卫生学院卫生统计学教研室

基金项目:

内蒙古自治区自然科学基金 2020MS08048

详细信息

通讯作者:
张星光，E-mail：zxg311@126.com

中图分类号: R181.2
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- 被引次数: 0
出版历程
- 收稿日期: 2021-05-23
- 修回日期: 2021-09-13
- 网络出版日期: 2022-04-14
- 刊出日期: 2022-04-10

Association between alcohol consumption pattern and health-related quality of life in individuals with high cardiovascular disease risk in Inner Mongolia, China

1.
Department of Epidemiology, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China
2.
Institute for the Prevention and Control of Endemic and Chronic Noncommunicable Diseases, Inner Mongolia Center for Disease Control and Prevention, Hohhot 010031, China
3.
Department of Child and Adolescent Hygiene, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China
4.
Department of Toxicology, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China
5.
Department of Health Statistics, School of Public health, Inner Mongolia Medical University, Hohhot 010110, China

Funds:

Natural Science Foundation Program of Inner Mongolia Autonomous Region 2020MS08048

More Information

Corresponding author: ZHANG Xing-guang, E-mail: zxg311@126.com

摘要

摘要: 目的研究心血管疾病(cardiovascular disease, CVD)高危人群中饮酒模式与健康相关生活质量(health-related quality of life, HRQoL)的关系。方法 2015-2017年采用多阶段分层整群随机抽样的方法选择内蒙古自治区(简称内蒙古)6个乡村或社区的常住居民进行横断面研究，研究内容包括问卷调查、体格检查和实验室检测，根据调查结果选择10年CVD发病风险≥10%的人群为高危人群，调查其饮酒模式与HRQoL。饮酒模式和HRQoL分别采用酒精使用障碍量表和欧洲五维健康量表(EuroQol Five-Dmensions Guestionnaire, EQ-5D)进行调查。采用多因素Logistic回归分析模型分析饮酒模式与HRQoL的关系。结果本研究共纳入CVD高危人群12 454人，其中不饮酒者占76.8%。与不饮酒者相比，男性中适量饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.652(95% CI: 1.437~1.901，P < 0.001)、1.758(95% CI: 1.507~2.049，P < 0.001);危险性饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.520(95% CI: 1.262~1.831，P < 0.001)、1.693(95% CI: 1.382~2.073，P < 0.001);女性中适量饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.536(95% CI: 1.223~1.930, P < 0.001)、1.566(95% CI: 1.237~1.982, P < 0.001)。结论建议CVD高危人群戒酒以提高其HRQoL。
- 心血管疾病 /
- 高危人群 /
- 饮酒模式 /
- 健康相关生活质量
Abstract: Objective To investigate the relationship between alcohol use and health-related quality of life (HRQoL) in people who were at high risk of cardiovascular disease (CVD). Methods From 2015 to 2017, permanent residents of 6 villages or settlements in Inner Mongolia were chosen as the research site, using a multi-stage stratified cluster random selection method. The study contents included questionnaire, physical examination and laboratory testing. Participants with a predicted risk of CVD more than 10% were identified as having a high CVD risk. Alcohol use disorders identification test and EuroQol Five-Dmensions Guestionnaire (EQ-5D) scale were used to investigate drinking patterns and HRQoL in high CVD risk groups. Multivariate Logistic regression was used to investigate the relationship between drinking patterns and HRQoL. Results Of 12 454 participants with high CVD risk, 76.8% were reported as nondrinkers. Compared with non-drinkers, the OR values of the risk of pain/discomfort and anxiety/depression among men who were low risk drinkers were 1.652 (95% CI: 1.437-1.901, P < 0.001) and 1.758 (95% CI: 1.507-2.049, P < 0.001); the OR values of risk of pain/discomfort and anxiety/depression of hazardous drinkers were 1.520 (95% CI: 1.262-1.831, P < 0.001) and 1.693 (95% CI: 1.382-2.073, P < 0.001). Compared with non-drinkers, the OR values of the risk of pain/discomfort and anxiety/depression among women who were low risk drinkers were 1.536 (95% CI: 1.223-1.930, P < 0.001) and 1.566 (95% CI: 1.237-1.982, P < .001). Conclusion It is suggested that those who have high risk of CVD should refrain from alcohol in order to enhance their health-related quality of life.
- Cardiovascular disease /
- High-risk individuals /
- Alcohol consumption pattern /
- Health-related quality of life

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表 1 内蒙古CVD高危人群的人口学特征[n(%)]

Table 1. Demographic characteristics of individuals with high CVD risk in Inner Mongolia [n(%)]

变量	男性(n=5 372)	女性(n=7 082)	合计
民族
汉族	4 753(88.5)	6 234(89.9)	11 117(89.3)
蒙古族	522(9.7)	608(8.6)	1 130(9.1)
其他民族	97(1.8)	110(1.5)	207(1.6)
婚姻状况
未婚	366(6.8)	930(13.1)	1 296(10.4)
已婚	5 006(93.2)	6 152(86.9)	11 158(89.6)
文化程度
高中以下	3 387(63.0)	5 800(81.9)	9 187(73.8)
高中及以上	1 985(37.0)	1 282(18.1)	3 267(26.2)
职业
非农民	3 045(56.7)	3 384(47.8)	6 429(51.6)
农民	2 327(43.3)	3 698(52.2)	6 025(48.4)
家庭年收入水平
< 5万元	4 594(85.5)	6 509(91.9)	11 103(89.2)
≥5万元	778(14.5)	573(8.1)	1 351(10.8)
吸烟
不吸烟或戒烟	2 649(49.3)	6 467(92.7)	9 216(74.0)
吸烟	2 723(50.7)	515(7.3)	3 238(26.0)
BMI (kg/m²)
正常及偏瘦	1 109(20.7)	1 487(21.1)	2 596(20.9)
超重	2 254(42.0)	3 001(42.5)	5 255(42.3)
肥胖	2 001(37.3)	2 568(36.4)	4 569(36.8)
高血压
否	437(8.1)	173(2.4)	610(4.9)
是	4 935(91.9)	6 909(97.6)	11 844(95.1)
糖尿病
否	3 694(68.8)	5 040(71.2)	8 734(70.1)
是	1 678(31.2)	2 042(28.8)	3 720(29.9)
血脂异常
否	2 439(45.4)	3 484(49.2)	5 923(47.6)
是	2 933(54.6)	3 598(50.8)	6 531(52.4)

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表 2 内蒙古CVD高危人群饮酒模式与EQ-5D各维度分布情况[n(%)]

Table 2. Alcohol consumption pattern and distribution of dimensions of EQ-5D in individuals with high CVD risk in Inner Mongolia [n(%)]

变量	男性	女性	合计	χ²值	P值
饮酒模式				3 346.457	< 0.001
不饮酒	2 851(53.1)	6 717(94.8)	9 568(76.8)
适量饮酒	1 554(28.9)	329(4.6)	1 883(15.1)
危险性饮酒	757(14.1)	33(0.6)	790(6.4)
有害饮酒	121(2.3)	3(0.0)	124(1.0)
酒精依赖	89(1.6)	0(0.0)	89(0.7)
EQ-5D五维度
行动				4.521	0.033
无困难	5 317(99.0)	6 979(98.5)	12 296(98.7)
有困难	55(1.0)	103(1.5)	158(1.3)
自我照顾能力				0.038	0.846
无困难	5 348(99.6)	7 052(99.6)	12 400(99.6)
有困难	24(0.4)	30(0.4)	54(0.4)
日常活动				3.388	0.066
无困难	5 318(99.0)	6 985(98.6)	12 303(98.8)
有困难	54(1.0)	97(1.4)	151(1.2)
疼痛/不舒服				70.349	< 0.001
无困难	3 948(73.5)	4 710(66.5)	8 658(69.5)
有困难	1 424(26.5)	2 373(33.5)	3 796(30.5)
焦虑/抑郁				54.381	< 0.001
无困难	4 295(80.0)	5 263(74.3)	9 558(76.7)
有困难	1 077(20.0)	1 819(25.7)	2 896(23.3)

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表 3 不同饮酒模式间EQ-5D各维度的情况比较[n(%)]

Table 3. Comparison of EQ-5D dimensions between different alcohol consumption patterns [n(%)]

饮酒模式	男性					女性
饮酒模式	行动(有困难者)	自我照顾能力(有困难者)	日常活动(有困难者)	疼痛/不舒服(有困难者)	焦虑/抑郁(有困难者)	行动(有困难者)	自我照顾能力(有困难者)	日常活动(有困难者)	疼痛/不舒服(有困难者)	焦虑/抑郁(有困难者)
不饮酒	39(1.4)	15(0.3)	37(1.3)	659(23.1)	475(16.7)	101(1.5)	30(0.4)	97(1.4)	2 216(33.0)	1 692(25.2)
适量饮酒	13(0.8)	7(0.1)	13(0.8)	499(32.1)	401(25.8)	2(0.6)	0(0.0)	0(0.0)	143(43.5)	116(35.3)
危险性饮酒	3(0.4)	2(0.0)	3(0.4)	213(28.1)	173(22.9)	0(0.0)	0(0.0)	0(0.0)	10(30.3)	8(24.2)
有害饮酒	0(0.0)	0(0.0)	0(0.0)	29(24.0)	19(15.7)	0(0.0)	0(0.0)	0(0.0)	3(100.0)	3(100.0)
酒精依赖	0(0.0)	0(0.0)	1(1.1)	24(27.0)	9(10.1)	-	-	-	-	-
χ²值	8.893	1.194	6.958	43.333	63.155	2.290	1.637	5.344	21.555	25.376
P	0.062	0.752	0.138	< 0.001	< 0.001	0.514	0.651	0.148	< 0.001	< 0.001

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表 4 不同饮酒模式与EQ-5D维度的关系^a

Table 4. Association between different alcohol consumption patterns and EQ-5D dimensions ^a

饮酒模式	男性		女性
饮酒模式	疼痛/不舒服OR(95% CI)值	焦虑/抑郁OR(95% CI)值	疼痛/不舒服OR(95% CI)值	焦虑/抑郁OR(95% CI)值
不饮酒	1.000	1.000	1.000	1.000
适量饮酒	1.652(1.437~1.901) ^b	1.758(1.507~2.049) ^b	1.536(1.223~1.930) ^b	1.566(1.237~1.982) ^b
危险性饮酒	1.520(1.262~1.831) ^b	1.693(1.382~2.073) ^b	1.266(0.636~2.520)	1.348(0.414~2.761)
有害饮酒	1.267(0.823~1.952)	1.015(0.611~1.686)
酒精依赖	1.453(0.897~2.354)	0.581(0.287~1.175)	—	—
注：^a校正了年龄、性别、民族、婚姻、文化程度、职业、收入、吸烟、BMI、高血压、糖尿病和血脂异常; ^b P < 0.001。

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变量	男性(n=5 372)	女性(n=7 082)	合计
民族
汉族	4 753(88.5)	6 234(89.9)	11 117(89.3)
蒙古族	522(9.7)	608(8.6)	1 130(9.1)
其他民族	97(1.8)	110(1.5)	207(1.6)
婚姻状况
未婚	366(6.8)	930(13.1)	1 296(10.4)
已婚	5 006(93.2)	6 152(86.9)	11 158(89.6)
文化程度
高中以下	3 387(63.0)	5 800(81.9)	9 187(73.8)
高中及以上	1 985(37.0)	1 282(18.1)	3 267(26.2)
职业
非农民	3 045(56.7)	3 384(47.8)	6 429(51.6)
农民	2 327(43.3)	3 698(52.2)	6 025(48.4)
家庭年收入水平
< 5万元	4 594(85.5)	6 509(91.9)	11 103(89.2)
≥5万元	778(14.5)	573(8.1)	1 351(10.8)
吸烟
不吸烟或戒烟	2 649(49.3)	6 467(92.7)	9 216(74.0)
吸烟	2 723(50.7)	515(7.3)	3 238(26.0)
BMI (kg/m²)
正常及偏瘦	1 109(20.7)	1 487(21.1)	2 596(20.9)
超重	2 254(42.0)	3 001(42.5)	5 255(42.3)
肥胖	2 001(37.3)	2 568(36.4)	4 569(36.8)
高血压
否	437(8.1)	173(2.4)	610(4.9)
是	4 935(91.9)	6 909(97.6)	11 844(95.1)
糖尿病
否	3 694(68.8)	5 040(71.2)	8 734(70.1)
是	1 678(31.2)	2 042(28.8)	3 720(29.9)
血脂异常
否	2 439(45.4)	3 484(49.2)	5 923(47.6)
是	2 933(54.6)	3 598(50.8)	6 531(52.4)

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内蒙古心血管病高危人群饮酒模式与健康相关生活质量的关系

doi: 10.16462/j.cnki.zhjbkz.2022.04.007

通讯作者:
张星光，E-mail：zxg311@126.com

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Association between alcohol consumption pattern and health-related quality of life in individuals with high cardiovascular disease risk in Inner Mongolia, China

Corresponding author: ZHANG Xing-guang, E-mail: zxg311@126.com

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内蒙古心血管病高危人群饮酒模式与健康相关生活质量的关系

doi: 10.16462/j.cnki.zhjbkz.2022.04.007

通讯作者: 张星光，E-mail：zxg311@126.com

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Association between alcohol consumption pattern and health-related quality of life in individuals with high cardiovascular disease risk in Inner Mongolia, China

Corresponding author: ZHANG Xing-guang, E-mail: zxg311@126.com

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通讯作者:
张星光，E-mail：zxg311@126.com