广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4<sup>+</sup>T淋巴细胞的关联

李剑军; 陈燕兰; 葛宪民; 岑平; 蓝光华; 阳世雄; 梁淑家; 唐凯玲; 方宁烨; 庞贤武; 何芹; 林兆森; 郭伟贵; 邓鑫晖; 冯献湘; 周丽芳; 黄运轩; 阳冬; 莫靖林; 钟坚; 莫洪志; 农爱丹; 梁旭; 覃熙茂; 莫实德; 曾梓; 罗柳红; 陈欢欢; 朱秋映; 朱金辉; 陆华湘; 孟琴; 刘帅凤; 李博

doi:10.16462/j.cnki.zhjbkz.2022.12.005

文章导航 > 中华疾病控制杂志 > 2022 > 26(12): 1389-1394

李剑军, 陈燕兰, 葛宪民, 岑平, 蓝光华, 阳世雄, 梁淑家, 唐凯玲, 方宁烨, 庞贤武, 何芹, 林兆森, 郭伟贵, 邓鑫晖, 冯献湘, 周丽芳, 黄运轩, 阳冬, 莫靖林, 钟坚, 莫洪志, 农爱丹, 梁旭, 覃熙茂, 莫实德, 曾梓, 罗柳红, 陈欢欢, 朱秋映, 朱金辉, 陆华湘, 孟琴, 刘帅凤, 李博. 广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4+T淋巴细胞的关联[J]. 中华疾病控制杂志, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

引用本文:

李剑军, 陈燕兰, 葛宪民, 岑平, 蓝光华, 阳世雄, 梁淑家, 唐凯玲, 方宁烨, 庞贤武, 何芹, 林兆森, 郭伟贵, 邓鑫晖, 冯献湘, 周丽芳, 黄运轩, 阳冬, 莫靖林, 钟坚, 莫洪志, 农爱丹, 梁旭, 覃熙茂, 莫实德, 曾梓, 罗柳红, 陈欢欢, 朱秋映, 朱金辉, 陆华湘, 孟琴, 刘帅凤, 李博. 广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4⁺T淋巴细胞的关联[J]. 中华疾病控制杂志, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4+T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

Citation:

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

引用本文:

李剑军, 陈燕兰, 葛宪民, 岑平, 蓝光华, 阳世雄, 梁淑家, 唐凯玲, 方宁烨, 庞贤武, 何芹, 林兆森, 郭伟贵, 邓鑫晖, 冯献湘, 周丽芳, 黄运轩, 阳冬, 莫靖林, 钟坚, 莫洪志, 农爱丹, 梁旭, 覃熙茂, 莫实德, 曾梓, 罗柳红, 陈欢欢, 朱秋映, 朱金辉, 陆华湘, 孟琴, 刘帅凤, 李博. 广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4⁺T淋巴细胞的关联[J]. 中华疾病控制杂志, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

Citation:

LI Jian-jun, CHEN Yan-lan, GE Xian-min, CEN Ping, LAN Guang-hua, YANG Shi-xiong, LIANG Shu-jia, TANG Kai-ling, FANG Ning-ye, PANG Xian-wu, HE Qin, LIN Zhao-sen, GUO Wei-gui, DENG Xin-hui, FENG Xian-xiang, ZHOU Li-fang, HUANG Yun-xuan, YANG Dong, MO Jing-lin, ZHONG Jian, MO Hong-zhi, NONG Ai-dan, LIANG Xu, QIN Xi-mao, MO Shi-de, ZENG Zi, LUO Liu-hong, CHEN Huan-huan, ZHU Qiu-ying, ZHU Jin-hui, LU Hua-xiang, MENG Qin, LIU Shuai-feng, LI Bo. Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(12): 1389-1394. doi: 10.16462/j.cnki.zhjbkz.2022.12.005

广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4⁺T淋巴细胞的关联

doi: 10.16462/j.cnki.zhjbkz.2022.12.005

李剑军¹,
陈燕兰²,
葛宪民^1, ,,
岑平^3, ,,
蓝光华¹,
阳世雄³,
梁淑家¹,
唐凯玲¹,
方宁烨¹,
庞贤武¹,
何芹¹,
林兆森²,
郭伟贵⁴,
邓鑫晖⁵,
冯献湘⁶,
周丽芳⁶,
黄运轩⁷,
阳冬⁸,
莫靖林⁸,
钟坚⁹,
莫洪志¹⁰,
农爱丹¹¹,
梁旭¹²,
覃熙茂¹³,
莫实德¹⁴,
曾梓¹⁵,
罗柳红¹,
陈欢欢¹,
朱秋映¹,
朱金辉¹,
陆华湘¹,
孟琴¹,
刘帅凤¹,
李博¹

1.
530028 南宁，广西壮族自治区疾病预防控制中心艾滋病防制所
2.
535099 钦州，钦州市疾病预防控制中心艾滋病防制科
3.
530023 南宁，南宁市疾病预防控制中心性病艾滋病防制科
4.
536000 北海，北海市疾病预防控制中心性病艾滋病防制科
5.
546100 来宾，来宾市疾病预防控制中心艾滋病防制科
6.
545007 柳州，柳州市疾病预防控制中心艾滋病防制所
7.
537100 贵港，贵港市疾病预防控制中心艾滋病防制科
8.
541001 桂林，桂林市疾病预防控制中心性病艾滋病防制科
9.
543002 梧州，梧州市疾病预防控制中心艾滋病防制科
10.
547000 河池，河池市疾病预防控制中心艾滋病与皮肤性病防制科
11.
532200 崇左，崇左市疾病预防控制中心性病与艾滋病预防控制科
12.
533000 百色，百色市疾病预防控制中心艾滋病皮肤病与性病防制科
13.
537000 玉林，玉林市疾病预防控制中心艾滋病防治科
14.
538021 防城港，防城港市疾病预防控制中心滋病防治科
15.
542899 贺州，贺州市疾病预防控制中心艾滋病防治科

李剑军和陈燕兰并列第一作者

基金项目:

广西重点研发计划项目 AB19245044

广西自然科学基金课题 2020GXNSFAA159020

广西八桂学者艾滋病防控关键技术岗位专项 [2019] No.79 issued by the General Office of GUI

广西艾滋病防控与成果转化研究重点实验 ZZH2020010

详细信息

通讯作者:
葛宪民，E-mail: gxgexm@sina.com

岑平，E-mail: cenping877@163.com

中图分类号: R183.9
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出版历程
- 收稿日期: 2022-09-21
- 修回日期: 2022-10-31
- 网络出版日期: 2022-12-30
- 刊出日期: 2022-12-10

Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020

1.
Institute of HIV/AIDS Prevention and Control, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning 530028, China
2.
Department of HIV/AIDS Prevention and Control, Qinzhou Center for Disease Control and Prevention, Qinzhou 535099, China
3.
Department of HIV/AIDS/STD Prevention and Control, Nanning Center for Disease Control and Prevention, Nanning 530023, China
4.
Department of HIV/AIDS/STD Prevention and Control, Beihai Center for Disease Control and Prevention, Beihai 536000, China
5.
Department of HIV/AIDS Prevention and Control, Laibin Center for Disease Control and Prevention, Laibin 546100, China
6.
Institute of HIV/AIDS Prevention and Control, Liuzhou Center for Disease Control and Prevention, Liuzhou 545007, China
7.
Department of HIV/AIDS Prevention and Control, Guigang Center for Disease Control and Prevention, Guigang 537100, China
8.
Department of HIV/AIDS/STD Prevention and Control, Guilin Center for Disease Control and Prevention, Guilin 541001, China
9.
Department of HIV/AIDS Prevention and Control, Wuzhou Center for Disease Control and Prevention, Wuzhou 543002, China
10.
Department of HIV/AIDS/STD Prevention and Control, Hechi Center for Disease Control and Prevention, Hechi 547000, China
11.
Department of HIV/AIDS/STD Prevention and Control, Chongzuo Center for Disease Control and Prevention, Chongzuo 532200, China
12.
Department of HIV/AIDS/STD Prevention and Control, Baise Center for Disease Control and Prevention, Baise 533000, China
13.
Department of HIV/AIDS Prevention and Control, Yulin Center for Disease Control and Prevention, Yulin 537000, China
14.
Department of HIV/AIDS Prevention and Control, Fangchenggang Center for Disease Control and Prevention, Fangchenggang 538021, China
15.
Department of HIV/AIDS Prevention and Control, Hezhou Center for Disease Control and Prevention, Hezhou 542899, China

LI Jian-jun and CHEN Yan-lan contributed equally to the article

Funds:

Guangxi Focus on research and development projects AB19245044

Guangxi Natural Science Foundation Project 2020GXNSFAA159020

Guangxi Bagui Honor Scholarship [2019] No.79 issued by the General Office of GUI

Guangxi Key Laboratory of AIDS Prevention Control and Translation ZZH2020010

More Information

Corresponding author: GE Xian-min, E-mail: gxgexm@sina.com; CEN Ping, E-mail: cenping877@163.com

摘要

摘要: 目的分析2020年广西壮族自治区(简称广西)新报告50岁及以上男性(简称中老年男性)HIV感染者的HIV-1基因亚型构成特点及不同基因亚型与首次CD4⁺T淋巴细胞(简称CD4)计数的关联。方法以市为抽样单位，采用分层随机抽样法选取广西2020年新报告中老年男性HIV感染者为研究对象，对其血浆进行病毒RNA提取、逆转录扩增、测序、HIV-1基因亚型和亚簇判定，使用多因素模型评价CD4计数可能存在统计学关联的影响因素。结果共纳入分析606例HIV感染者，主要流行毒株有CRF01_AE、CRF07_BC及CRF08_BC三种，其构成比分别为57.6%(349/606)、17.2%(104/606)及22.1%(134/606)，其首次CD4中位数分别为145(51, 271) 个/μL、212(110, 330) 个/μL及178(100, 307)个/μL。CRF01_AE感染者首次CD4值低于CRF07_BC感染者(Z=-3.363, P=0.002)，也低于CRF08_BC感染者(Z=-2.983, P=0.009)。二元logistic回归分析模型分析显示，CRF01_AE为广西中老年人群CD4≤200个/μL的独立危险因素(aOR=1.453, 95% CI: 1.047~2.017)。结论 CRF01_AE、CRF07_BC和CRF08_BC为广西2020年新报告中老年男性HIV感染者主要毒株，其构成以CRF01_AE为主，CRF01_AE为CD4≤200个/μL的独立危险因素，提示感染CRF01_AE毒株中老年男性的疾病进展较快，对广西艾滋病流行危害较大。
- 艾滋病病毒 /
- 中老年男性 /
- 基因亚型 /
- CD4⁺T淋巴细胞计数
Abstract: Objective To analyze the compositional characteristics of HIV-1 genotype among HIV-infected men aged 50 and over (referred to as middle-aged and elderly men) newly reported in Guangxi in 2020, and to analyze the association between different genotypes and the CD4⁺ T lymphocyte(referred to as CD4) count at HIV diagnosis. Methods The stratified random sampling method was used to select middle-aged and elderly male HIV-infected patients in 2020 newly reported in 14 cities in Guangxi as the research subjects, and the plasma of infected patients was subjected to viral RNA extraction, reverse transcription amplification, sequencing, HIV-1 genotype and sub-cluster determination. A multivariate model was used to evaluate possible statistically associated influencing factors of CD4 counts. Results A total of 606 HIV-infected patients were included and analyzed, and the main circulating strains were CRF01_AE, CRF07_BC and CRF08_BC, and their proportions were 57.6%(349/606), 17.2%(104/606) and 22.1%(134/606) respectively, and the medians of their first CD4 at diagnosis were 145(51, 271), 212(110, 330) and 178(100, 307) cells/μL, respectively. The first CD4 count at diagnosis of CRF01_AE infected patients was lower than that of CRF07_BC infected patients(Z=-3.363, P=0.002), and lower than that of CRF08_BC infected patients(Z=-2.983, P=0.009). Binary logistic regression model showed that CRF01_AE was an independent risk factor for CD4 ≤200 cells/μL among newly reported middle-aged and elderly men with HIV infection in Guangxi(aOR=1.453, 95% CI: 1.047-2.017). Conclusions CRF01_AE, CRF07_BC and CRF08_BC are the three main circulating strains of HIV infection among middle-aged and elderly males newly reported in Guangxi in 2020, and major in CRF01_AE. CRF01_AE is an independent risk factor for CD4 ≤200 cells/μL, suggesting that the disease progresses rapidly in middle-aged and elderly men with CRF01_AE strain, which is more harmful to the HIV/AIDS epidemic in Guangxi.
- HIV /
- Middle-aged and elderly men /
- Genetic subtypes /
- CD4⁺T cell counts

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图 1 广西2020年新报告中老年男性HIV感染者的HIV-1主要基因亚型系统进化树

Figure 1. Phylogenetic tree of major HIV-1 subtypes among middle-aged and elderly male HIV cases newly reported in Guangxi in 2020

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图 2 广西新报告中老年男性HIV感染者的不同基因亚型首次CD4计数比较

Figure 2. Comparison of the first CD4 counts of different subtypes among newly reported middle-aged and elderly male HIV cases in Guangxi

下载: 全尺寸图片幻灯片

表 1 广西2020年新报告606例中老年男性HIV感染者的基本情况及亚型分布特征[n(%)]

Table 1. The basic characteristics and subtypes distribution of 606 middle-aged and elderly males HIV cases newly reported in 2020 in Guangxi [n(%)]

变量	合计(N=606)	基因亚型		χ²值	P值
变量	合计(N=606)	CRF01_AE (n=349)	其他亚型(n=257)	χ²值	P值
年龄(岁)				2.534	0.282
50~＜60	228(37.6)	122(35.0)	106(41.2)
60~＜70	238(39.3)	142(40.7)	96(37.4)
≥70	140(23.1)	85(24.3)	55(21.4)
职业				2.301	0.129
农民	522(86.1)	307(88.0)	215(83.7)
非农民	84(13.9)	42(12.0)	42(16.3)
婚姻状况				0.044	0.834
已婚有配偶	359(59.3)	208(59.6)	151(58.7)
其他	247(40.7)	141(40.4)	106(41.3)
民族				0.009	0.925
汉族	350(57.8)	201(57.6)	149(58.0)
其他	256(42.2)	148(42.4)	108(42.0)
文化程度				0.646	0.422
文盲及小学	379(62.5)	223(63.9)	156(60.7)
初中及以上	227(37.5)	126(36.1)	101(39.3)
感染途径					1.000 ^a
异性传播	602(99.3)	347(99.4)	255(99.2)
同性传播	4(0.7)	2(0.6)	2(0.8)
首次CD4(个/μL)				4.895	0.027
≤200	352(58.1)	216(61.9)	136(52.9)
＞200	254(41.9)	133(38.1)	121(47.1)
注：其他亚型，包括CRF07_BC、CRF08_BC、CRF55_01B、CRF85_BC、B、C和URFs；括号内为构成比，省略“%”，括号外为绝对数; ^a表示使用Fisher精确概率法计算所得P值。

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表 2 广西新报告中老年男性HIV感染者的CD4≤200的二元logistic回归分析模型

Table 2. Binary logistic regression analysis for CD4 ≤200 among middle-aged and elderly male HIV cases newly reported in Guangxi

变量	β值	s_x值	Wald值	aOR(95% CI)值	P值
HIV-1亚组
CRF01_AE	0.374	0.167	4.988	1.453(1.047~2.017)	0.026
其他亚型				1.000
年龄组(岁)
50~＜60	-0.222	0.218	1.042	0.801(0.523~1.227)	0.307
60~＜70	-0.290	0.216	1.798	0.748(0.490~1.143)	0.180
≥70				1.000
常量	-0.291	0.183	2.534		0.111

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广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4⁺T淋巴细胞的关联

doi: 10.16462/j.cnki.zhjbkz.2022.12.005

通讯作者:
葛宪民，E-mail: gxgexm@sina.com

岑平，E-mail: cenping877@163.com

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Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020

Corresponding author: GE Xian-min, E-mail: gxgexm@sina.com; CEN Ping, E-mail: cenping877@163.com

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广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4+T淋巴细胞的关联

doi: 10.16462/j.cnki.zhjbkz.2022.12.005

通讯作者: 葛宪民，E-mail: gxgexm@sina.com 岑平，E-mail: cenping877@163.com

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Distribution of HIV-1 genotypes and its association with first CD4+T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020

Corresponding author: GE Xian-min, E-mail: gxgexm@sina.com; CEN Ping, E-mail: cenping877@163.com

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广西壮族自治区2020年新报告≥50岁男性HIV感染者的HIV-1基因亚型分布及其与首次CD4⁺T淋巴细胞的关联

通讯作者:
葛宪民，E-mail: gxgexm@sina.com

岑平，E-mail: cenping877@163.com

Distribution of HIV-1 genotypes and its association with first CD4⁺T lymphocytes among HIV-infected men aged 50 and over newly reported in Guangxi in 2020