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幽门螺杆菌感染与代谢综合征的横断面研究

陈媛媛 胡志强 胡景岑 吴雅娴 马铮 吕筠 孙点剑一 满塞丽麦 王晓娜 王波 余灿清 李立明

陈媛媛, 胡志强, 胡景岑, 吴雅娴, 马铮, 吕筠, 孙点剑一, 满塞丽麦, 王晓娜, 王波, 余灿清, 李立明. 幽门螺杆菌感染与代谢综合征的横断面研究[J]. 中华疾病控制杂志, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015
引用本文: 陈媛媛, 胡志强, 胡景岑, 吴雅娴, 马铮, 吕筠, 孙点剑一, 满塞丽麦, 王晓娜, 王波, 余灿清, 李立明. 幽门螺杆菌感染与代谢综合征的横断面研究[J]. 中华疾病控制杂志, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015
CHEN Yuanyuan, HU Zhiqiang, HU Jingcen, WU Yaxian, MA Zheng, LYU Jun, SUN Dianjianyi, MAN Sailimai, WANG Xiaona, WANG Bo, YU Canqing, LI Liming. A cross-sectional study of Helicobacter pylori infection and metabolic syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015
Citation: CHEN Yuanyuan, HU Zhiqiang, HU Jingcen, WU Yaxian, MA Zheng, LYU Jun, SUN Dianjianyi, MAN Sailimai, WANG Xiaona, WANG Bo, YU Canqing, LI Liming. A cross-sectional study of Helicobacter pylori infection and metabolic syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015

幽门螺杆菌感染与代谢综合征的横断面研究

doi: 10.16462/j.cnki.zhjbkz.2024.03.015
基金项目: 

国家自然科学基金 82192900

国家自然科学基金 82192901

国家自然科学基金 82192904

详细信息
    通讯作者:

    余灿清,E-mail:yucanqing@pku.edu.cn

    王波,E-mail:paul@meinianresearch.com

  • 中图分类号: R181

A cross-sectional study of Helicobacter pylori infection and metabolic syndrome

Funds: 

National Natural Science Foundation of China 82192900

National Natural Science Foundation of China 82192901

National Natural Science Foundation of China 82192904

More Information
  • 摘要:   目的  探究幽门螺杆菌感染与代谢综合征(metabolic syndrome, MetS)的横断面关联,为早期预防提供参考依据。  方法  利用北京美兆健康体检中心2009―2020年年龄≥18岁人群的体检资料,其中幽门螺杆菌感染情况由13C-尿素呼气试验检测,代谢综合征及其4个组成部分(腹型肥胖、高血糖、血压升高和血脂异常)的诊断参照《中国成人血脂异常防治指南》的定义,采取横断面调查设计,应用多变量logistic回归分析模型探究幽门螺杆菌感染与MetS及其4个组成部分的关联。  结果  共纳入31 369名体检对象,年龄为(45.3±11.6)岁,其中男性占58.7%。幽门螺杆菌阳性检出率为35.7%,MetS患病率为25.6%,其中男性MetS患病率高于女性。在调整了社会人口学、生活方式、高血压和糖尿病家族史等潜在混杂因素后,幽门螺杆菌感染者患代谢综合征(OR=1.18, 95% CI: 1.11~1.25, P<0.001)及其4个组分的风险更高,其中腹型肥胖(OR=1.18, 95% CI: 1.11~1.24, P<0.001)、血脂异常(OR=1.14, 95% CI: 1.06~1.22, P<0.001)的关联强度较高,且女性中血脂异常的关联强度高于男性(P=0.003)。  结论  我国成人幽门螺杆菌感染与高MetS及其组成部分的患病风险有关。
  • 图  1  男、女性代谢综合征及其4个组分的患病率

    Figure  1.  Prevalence rate of metabolic syndrome and its four components by gender

    表  1  不同幽门螺杆菌感染状态的体检对象的基本特征

    Table  1.   Characteristics of participants according to Helicobacter pylori infection status in MJHSC Database

    特征Characteristic 幽门螺杆菌感染状态 Helicobacter pylori infection status t2/Z值value P值value
    阴性Negative 阳性Positive
    人数Number of participants 20 177 11 192
    年龄/岁Age/years 45.0±11.7 45.9±11.4 6.9 <0.001
    已婚Married 17 426(86.4) 9 972(89.1) 48.7 <0.001
    大学及以上College and above 17 846(88.4) 9 452(84.5) 101.7 <0.001
    年收入/元Annual income/yuan 5.5 <0.001
      <100 000 6 992(34.7) 4 285(38.3)
      100 000~199 999 6 116(30.3) 3 180(28.4)
      ≥200 000 7 069(35.0) 3 727(33.3)
    吸烟Smoking 143.5 <0.001
      从不Never 14 293(70.8) 7 222(64.5)
      戒烟Former smoker 1 270(6.3) 753(6.7)
      吸烟Current drinker 4 614(22.9) 3 217(28.7)
    饮酒Drinking 141.0 <0.001
      从不Never 14 240(70.6) 7 171(64.1)
      戒酒Former drinker 634(3.1) 412(3.7)
      饮酒Current drinker 5 303(26.3) 3 609(32.2)
    膳食/(单位·周-1) Diet/(unit·week-1)
      蔬菜Vegetable 2.0(2.0, 3.5) 2.0(2.0, 3.5) 3.2 0.001
      水果Fruit 2.0(0.0, 2.0) 2.0(0.0, 2.0) 9.0 <0.001
      肉类Meat 5.0(2.0, 7.0) 5.0(2.0, 7.0) -1.2 0.232
      油炸食品Fried food 0.0(0.0, 2.0) 0.0(0.0, 2.0) -1.1 0.278
    体力活动/[MET-(h·d-1)] Physical activity/[MET-(h·d-1)] 28.2±37.9 29.6±39.7 2.9 0.004
    高血压家族史Family history of hypertension 7 927(39.3) 4 165(37.2) 13.1 <0.001
    糖尿病家族史Family history of diabetes 5 016(24.9) 2 623(23.4) 7.9 0.005
    注:①以人数(占比/%)、x±sM(P25P75)表示。
    Note: ①Number of people (proportion/%) or x±s or M(P25P75).
    下载: 导出CSV

    表  2  幽门螺杆菌感染与代谢综合征及4个组分的横断面关联

    Table  2.   Cross-sectional associations between Helicobacter pylori infection and metabolic syndrome, as well as its four components

    变量Variable 患病人数(患病率/%)Number of case(prevalence/%) 粗模型Crude model 模型1Model 1 模型2Model 2 模型3Model 3
    幽门螺杆菌H. pylori (-) 幽门螺杆菌H. pylori (+) OR值value(95% CI) P值value OR值value(95% CI) P值value OR值value(95% CI) P值value OR值value(95% CI) P值value
    代谢综合征Metabolic syndrome 4 769(23.64) 3 252(29.06) 1.32(1.26~1.39) <0.001 1.22(1.15~1.29) <0.001 1.19(1.13~1.26) <0.001 1.18(1.11~1.25) <0.001
    腹型肥胖Abdominal obesity 6 451(31.97) 4 281(38.25) 1.32(1.26~1.38) <0.001 1.22(1.16~1.28) <0.001 1.19(1.13~1.25) <0.001 1.18(1.11~1.24) <0.001
    高血糖Hyperglycemia 6 043(29.95) 3 786(33.83) 1.20(1.14~1.26) <0.001 1.10(1.04~1.16) <0.001 1.08(1.02~1.14) 0.006 1.07(1.01~1.13) 0.022
    血压升高High blood pressure 6 214(30.80) 3 832(34.24) 1.17(1.11~1.23) <0.001 1.07(1.02~1.13) 0.008 1.06(1.00~1.12) 0.036 1.07(1.01~1.13) 0.019
    血脂异常Dyslipidemia 2 466(12.22) 1 682(15.03) 1.27(1.19~1.36) <0.001 1.18(1.10~1.26) <0.001 1.15(1.08~1.24) <0.001 1.14(1.06~1.22) <0.001
    下载: 导出CSV
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出版历程
  • 收稿日期:  2023-08-04
  • 修回日期:  2024-01-06
  • 网络出版日期:  2024-04-08
  • 刊出日期:  2024-03-10

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