Research advance on the association between occupational dust exposure and the risk of rheumatoid arthritis
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摘要: 类风湿关节炎(rheumatoid arthritis, RA)是一种与慢性炎症过程相关的自身免疫性疾病，主要影响关节，导致关节疼痛、僵硬和功能障碍等症状。同时，RA是一种慢性致残性疾病，影响患者的生活质量和预期寿命，已成为一个重要的公共卫生问题，给个人和社会带来了负担。其病因和发病机制尚未完全明确，近年来发现生产性粉尘暴露可能是RA发生的危险因素，同时相关的流行病学研究也取得了一定的成就，有利于RA的病因研究、诊断和预防。本研究将综述现有关于生产性粉尘暴露与RA发生的流行病学研究进展，以期提供更深入的研究思路和方向。Abstract: Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation. It primarily affects the joints, leading to joint pain, stiffness, and functional impairment. RA is also a chronic disabling disease that impacts patients′ quality of life and life expectancy, making it a significant public health concern that burdens both individuals and society. The etiology and pathogenesis of RA are not fully understood; however, in recent years, studies have suggested that occupational dust exposure may be a risk factor for RA development. Concurrently, epidemiological research has made progress in understanding RA′s causes, diagnosis, and prevention. This article reviews the progress in epidemiological research on the relationship between occupational dust exposure and the occurrence of RA, aiming to provide deeper insights and directions for further investigation.
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Key words:
- Dust /
- Rheumatoid arthritis /
- Epidemiology /
- Research advance
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图 1 生产性粉尘在RA发生中的作用
RA:类风湿关节炎。
Figure 1. The role of occupational dust in causing RA
RA:rheumatoid arthritis.
表 1 生产性粉尘的分类和常见职业暴露工种
Table 1. Classification of occupational dust and common types of occupational exposure
粉尘
Dust分类
Classification常见的粉尘
Common dust types常见的职业暴露工种
Typical occupational exposures无机粉尘
Inorganic dust矿物性粉尘
Mineral dust二氧化硅、石棉、滑石、煤、稀土等
Silica, asbestos, talc, coal, rare earth, etc矿工、石材工人、砂石厂工人等
Miners, stone workers, sand and gravel factory workers, etc金属性粉尘
Metallic dust铅、锰、铁等及其化合物
Lead, manganese, iron, and their compounds冶金工人、焊工、金属加工工人等
Metallurgical workers, welders, metal processing workers, etc人工无机粉尘Artificial inorganic dust 金刚砂、水泥、玻璃纤维等Emery, cement, glass fiber, etc 化工工人、建筑材料制造工人、陶瓷工人等Chemical workers, building material manufacturing workers, ceramic workers, etc 有机粉尘
Organic dust动物性粉尘
Animal-derived dust皮毛、丝、骨、角质粉尘等
Fur, silk, bone, keratin dust, etc养殖工人、畜牧工人、动物实验室工作人员等
Animal husbandry workers, livestock workers, animal laboratory staff, etc植物性粉尘
Plant-derived dust棉、麻、谷物、甘蔗、烟草、木尘等
Cotton, hemp, grains, sugarcane, tobacco, wood dust, etc农民、木工、食品加工工人等
Farmers, carpenters, food processing workers, etc人工有机粉尘
Artificial organic dust合成树脂、橡胶、人造有机纤维粉尘等
Synthetic resins, rubber, synthetic organic fiber dust, etc化工工人、塑料制造工人、油漆工人等
Chemical workers, plastic manufacturing workers, painters, etc
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