• 中国精品科技期刊
  • 《中文核心期刊要目总览》收录期刊
  • RCCSE 中国核心期刊(5/114,A+)
  • Scopus收录期刊
  • 美国《化学文摘》(CA)收录期刊
  • WHO 西太平洋地区医学索引(WPRIM)收录期刊
  • 《中国科学引文数据库(CSCD)》核心库期刊 (C)
  • 中国科技核心期刊
  • 中国科技论文统计源期刊
  • 《日本科学技术振兴机构数据库(中国)》(JSTChina)收录期刊
  • 美国《乌利希期刊指南》(UIrichsweb)收录期刊
  • 中华预防医学会系列杂志优秀期刊(2019年)

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

生产性粉尘暴露与类风湿关节炎发生风险的研究进展

张紫行 方心宇 王佳 穆敏 朱峰林 钱婷婷 叶冬青

张紫行, 方心宇, 王佳, 穆敏, 朱峰林, 钱婷婷, 叶冬青. 生产性粉尘暴露与类风湿关节炎发生风险的研究进展[J]. 中华疾病控制杂志, 2024, 28(3): 351-356. doi: 10.16462/j.cnki.zhjbkz.2024.03.017
引用本文: 张紫行, 方心宇, 王佳, 穆敏, 朱峰林, 钱婷婷, 叶冬青. 生产性粉尘暴露与类风湿关节炎发生风险的研究进展[J]. 中华疾病控制杂志, 2024, 28(3): 351-356. doi: 10.16462/j.cnki.zhjbkz.2024.03.017
ZHANG Zixing, FANG Xinyu, WANG Jia, MU Min, ZHU Fenglin, QIAN Tingting, YE Dongqing. Research advance on the association between occupational dust exposure and the risk of rheumatoid arthritis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 351-356. doi: 10.16462/j.cnki.zhjbkz.2024.03.017
Citation: ZHANG Zixing, FANG Xinyu, WANG Jia, MU Min, ZHU Fenglin, QIAN Tingting, YE Dongqing. Research advance on the association between occupational dust exposure and the risk of rheumatoid arthritis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 351-356. doi: 10.16462/j.cnki.zhjbkz.2024.03.017

生产性粉尘暴露与类风湿关节炎发生风险的研究进展

doi: 10.16462/j.cnki.zhjbkz.2024.03.017
基金项目: 

临床医学研究转化专项 202304295107020048

炎症免疫性疾病安徽省实验室开放课题 IMMDL20220004

详细信息
    通讯作者:

    叶冬青,E-mail:anhuiydq@126.com

    方心宇,E-mail:xinyufang@ahmu.edu.cn

  • 中图分类号: R593.22

Research advance on the association between occupational dust exposure and the risk of rheumatoid arthritis

Funds: 

Special Project for Transformation of Clinical Medical Research 202304295107020048

Inflammatory Immune Diseases Open Research Project in Anhui Province Laboratory IMMDL20220004

More Information
  • 摘要: 类风湿关节炎(rheumatoid arthritis, RA)是一种与慢性炎症过程相关的自身免疫性疾病,主要影响关节,导致关节疼痛、僵硬和功能障碍等症状。同时,RA是一种慢性致残性疾病,影响患者的生活质量和预期寿命,已成为一个重要的公共卫生问题,给个人和社会带来了负担。其病因和发病机制尚未完全明确,近年来发现生产性粉尘暴露可能是RA发生的危险因素,同时相关的流行病学研究也取得了一定的成就,有利于RA的病因研究、诊断和预防。本研究将综述现有关于生产性粉尘暴露与RA发生的流行病学研究进展,以期提供更深入的研究思路和方向。
  • 图  1  生产性粉尘在RA发生中的作用

    RA:类风湿关节炎。

    Figure  1.  The role of occupational dust in causing RA

    RA:rheumatoid arthritis.

    表  1  生产性粉尘的分类和常见职业暴露工种

    Table  1.   Classification of occupational dust and common types of occupational exposure

    粉尘
    Dust
    分类
    Classification
    常见的粉尘
    Common dust types
    常见的职业暴露工种
    Typical occupational exposures
    无机粉尘
    Inorganic dust
    矿物性粉尘
    Mineral dust
    二氧化硅、石棉、滑石、煤、稀土等
    Silica, asbestos, talc, coal, rare earth, etc
    矿工、石材工人、砂石厂工人等
    Miners, stone workers, sand and gravel factory workers, etc
    金属性粉尘
    Metallic dust
    铅、锰、铁等及其化合物
    Lead, manganese, iron, and their compounds
    冶金工人、焊工、金属加工工人等
    Metallurgical workers, welders, metal processing workers, etc
    人工无机粉尘Artificial inorganic dust 金刚砂、水泥、玻璃纤维等Emery, cement, glass fiber, etc 化工工人、建筑材料制造工人、陶瓷工人等Chemical workers, building material manufacturing workers, ceramic workers, etc
    有机粉尘
    Organic dust
    动物性粉尘
    Animal-derived dust
    皮毛、丝、骨、角质粉尘等
    Fur, silk, bone, keratin dust, etc
    养殖工人、畜牧工人、动物实验室工作人员等
    Animal husbandry workers, livestock workers, animal laboratory staff, etc
    植物性粉尘
    Plant-derived dust
    棉、麻、谷物、甘蔗、烟草、木尘等
    Cotton, hemp, grains, sugarcane, tobacco, wood dust, etc
    农民、木工、食品加工工人等
    Farmers, carpenters, food processing workers, etc
    人工有机粉尘
    Artificial organic dust
    合成树脂、橡胶、人造有机纤维粉尘等
    Synthetic resins, rubber, synthetic organic fiber dust, etc
    化工工人、塑料制造工人、油漆工人等
    Chemical workers, plastic manufacturing workers, painters, etc
    下载: 导出CSV
  • [1] Conforti A, Di Cola I, Pavlych V, et al. Beyond the joints, the extra-articular manifestations in rheumatoid arthritis [J]. Autoimmun Rev, 2021, 20(2): 102735. DOI: 10.1016/j.autrev.2020.102735.
    [2] Safiri S, Kolahi AA, Hoy D, et al. Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017 [J]. Ann Rheum Dis, 2019, 78(11): 1463-1471. DOI: 10.1136/annrheumdis-2019-215920.
    [3] Li R, Sun J, Ren LM, et al. Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing [J]. Rheumatology, 2012, 51(4): 721-729. DOI: 10.1093/rheumatology/ker370.
    [4] Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis [J]. Lancet, 2016, 388(10055): 2023-2038. DOI: 10.1016/s0140-6736(16)30173-8.
    [5] Salliot C, Nguyen Y, Boutron-Ruault MC, et al. Environment and lifestyle: their influence on the risk of RA [J]. J Clin Med, 2020, 9(10): 3109. DOI: 10.3390/jcm9103109.
    [6] Ilar A, Alfredsson L, Wiebert P, et al. Occupation and risk of developing rheumatoid arthritis: results from a population-based case-control study [J]. Arthritis Care Res, 2018, 70(4): 499-509. DOI: 10.1002/acr.23321.
    [7] Deane KD, Demoruelle MK, Kelmenson LB, et al. Genetic and environmental risk factors for rheumatoid arthritis[J]. Best Pract Res Clin Rheumatol, 2017, 31(1): 3-18. DOI: 10.1016/j.berh.2017.08.003.
    [8] Mehri F, Jenabi E, Bashirian S, et al. The association between occupational exposure to silica and risk of developing rheumatoid arthritis: a meta-analysis [J]. Saf Health Work, 2020, 11(2): 136-142. DOI: 10.1016/j.shaw.2020.02.001.
    [9] Klockars M, Koskela RS, Järvinen E, et al. Silica exposure and rheumatoid arthritis: a follow up study of granite workers 1940-81 [J]. Br Med J (Clin Res Ed), 1987, 294(6578): 997-1000. DOI: 10.1136/bmj.294.6578.997.
    [10] Calvert GM, Rice FL, Boiano JM, et al. Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States [J]. Occup Environ Med, 2003, 60(2): 122-129. DOI: 10.1136/oem.60.2.122.
    [11] Stolt P, Källberg H, Lundberg I, et al. Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study [J]. Ann Rheum Dis, 2005, 64(4): 582-586. DOI: 10.1136/ard.2004.022053.
    [12] Yahya A, Bengtsson C, Larsson P, et al. Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study [J]. Mod Rheumatol, 2014, 24(2): 271-274. DOI: 10.3109/14397595.2013.854076.
    [13] Vihlborg P, Bryngelsson IL, Andersson L, et al. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study [J]. BMJ Open, 2017, 7(7): e016839. DOI: 10.1136/bmjopen-2017-016839.
    [14] Blanc PD, Järvholm B, Torén K. Prospective risk of rheumatologic disease associated with occupational exposure in a cohort of male construction workers [J]. Am J Med, 2015, 128(10): 1094-1101. DOI: 10.1016/j.amjmed.2015.05.001.
    [15] Steenland K, Brown D. Mortality study of gold miners exposed to silica and nonasbestiform amphibole minerals: an update with 14 more years of follow-up [J]. Am J Ind Med, 1995, 27(2): 217-229. DOI: 10.1002/ajim.4700270207.
    [16] Turner S, Cherry N. Rheumatoid arthritis in workers exposed to silica in the pottery industry [J]. Occup Environ Med, 2000, 57(7): 443-447. DOI: 10.1136/oem.57.7.443.
    [17] Klareskog L, Malmström V, Lundberg K, et al. Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis [J]. Semin Immunol, 2011, 23(2): 92-98. DOI: 10.1016/j.smim.2011.01.014.
    [18] Brown JM, Pfau JC, Pershouse MA, et al. Silica, apoptosis, and autoimmunity [J]. J Immunotoxicol, 2005, 1(3): 177-187. DOI: 10.1080/15476910490911922.
    [19] Rocha MC, Santos LMB, Bagatin E, et al. Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers [J]. Int J Hyg Environ Health, 2012, 215(6): 562-569. DOI: 10.1016/j.ijheh.2011.10.010.
    [20] Fee L, Kumar A, Tighe RM, et al. Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice [J]. Front Immunol, 2022, 13: 933360. DOI: 10.3389/fimmu.2022.933360.
    [21] Tang BW, Liu QW, Ilar A, et al. Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking [J]. Ann Rheum Dis, 2023, 82(3): 316-323. DOI: 10.1136/ard-2022-223134.
    [22] Hussein AM, Attia DI, Zayed BEM, et al. Pulmonary functions and oxidative stress biomarkers among silica-exposed foundry workers [J]. J Occup Environ Med, 2023, 65(5): 437-442. DOI: 10.1097/jom.0000000000002815.
    [23] Olsson AR, Skogh T, Axelson O, et al. Occupations and exposures in the work environment as determinants for rheumatoid arthritis [J]. Occup Environ Med, 2004, 61(3): 233-238. DOI: 10.1136/oem.2003.007971.
    [24] Noonan CW, Pfau JC, Larson TC, et al. Nested case-control study of autoimmune disease in an asbestos-exposed population [J]. Environ Health Perspect, 2006, 114(8): 1243-1247. DOI: 10.1289/ehp.9203.
    [25] Ilar A, Klareskog L, Saevarsdottir S, et al. Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study [J]. RMD Open, 2019, 5(2): e000978. DOI: 10.1136/rmdopen-2019-000978.
    [26] Lange A. An epidemiological survey of immunological abnormalities in asbestos workers. [J]. Environ Res, 1980, 22(1): 176-183. DOI: 10.1016/0013-9351(80)90129-2.
    [27] Zerva LV, Constantopoulos SH, Moutsopoulos HM. Humoral immunity alterations after environmental asbestos exposure [J]. Respiration, 1989, 55(4): 237-241. DOI: 10.1159/000195740.
    [28] Maeda M, Nishimura Y, Hayashi H, et al. Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2 [J]. Am J Respir Cell Mol Biol, 2011, 45(3): 470-479. DOI: 10.1165/rcmb.2010-0213oc.
    [29] Pfau JC, Sentissi JJ, Li SA, et al. Asbestos-induced autoimmunity in C57BL/6 mice [J]. J Immunotoxicol, 2008, 5(2): 129-137. DOI: 10.1080/15476910802085756.
    [30] Zebedeo CN, Davis C, Peña C, et al. Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice [J]. Toxicol Appl Pharmacol, 2014, 275(3): 257-264. DOI: 10.1016/j.taap.2014.01.018.
    [31] Cappelletti R, Ceppi M, Claudatus J, et al. Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy [J]. J Occup Med Toxicol, 2016, 11: 7. DOI: 10.1186/s12995-016-0095-8.
    [32] Too CL, Muhamad NA, Ilar A, et al. Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study [J]. Ann Rheum Dis, 2016, 75(6): 997-1002. DOI: 10.1136/annrheumdis-2015-208278.
    [33] Ilar A, Gustavsson P, Wiebert P, et al. Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study [J]. RMD Open, 2019, 5(2): e001049. DOI: 10.1136/rmdopen-2019-001049.
    [34] Deetz DC, Jagielo PJ, Quinn TJ, et al. The kinetics of grain dust-induced inflammation of the lower respiratory tract [J]. Am J Respir Crit Care Med, 1997, 155(1): 254-259. DOI: 10.1164/ajrccm.155.1.9001321.
    [35] Wang Z, Larsson K, Palmberg L, et al. Inhalation of swine dust induces cytokine release in the upper and lower airways [J]. Eur Respir J, 1997, 10(2): 381-387. DOI: 10.1183/09031936.97.10020381.
    [36] Lai PS, Christiani DC. Long-term respiratory health effects in textile workers [J]. Curr Opin Pulm Med, 2013, 19(2): 152-157. DOI: 10.1097/MCP.0b013e32835cee9a.
    [37] Rylander R. Endotoxin and occupational airway disease [J]. Curr Opin Allergy Clin Immunol, 2006, 6(1): 62-66. DOI: 10.1097/01.all.0000202356.83509.f7.
    [38] Poole JA, Wyatt TA, Oldenburg PJ, et al. Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice [J]. Am J Physiol Lung Cell Mol Physiol, 2009, 296(6): L1085-L1095. DOI: 10.1152/ajplung.90622.2008.
    [39] Poole JA, Thiele GM, Janike K, et al. Combined collagen-induced arthritis and organic dust-induced airway inflammation to model inflammatory lung disease in rheumatoid arthritis [J]. J Bone Miner Res, 2019, 34(9): 1733-1743. DOI: 10.1002/jbmr.3745.
    [40] Parks CG, Conrad K, Cooper GS. Occupational exposure to crystalline silica and autoimmune disease [J]. Environ Health Perspect, 1999, 107(Suppl 5): 793-802. DOI: 10.1289/ehp.99107s5793.
  • 加载中
图(1) / 表(1)
计量
  • 文章访问数:  58
  • HTML全文浏览量:  21
  • PDF下载量:  9
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-09-19
  • 修回日期:  2024-01-15
  • 网络出版日期:  2024-04-08
  • 刊出日期:  2024-03-10

目录

    /

    返回文章
    返回