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老年人血浆IL-6、TNF-α水平与轻度认知功能障碍的关联

吴茵如 钟逸诗 高健 陈沛良 由芳菲 宋玮琦 毛琛

吴茵如, 钟逸诗, 高健, 陈沛良, 由芳菲, 宋玮琦, 毛琛. 老年人血浆IL-6、TNF-α水平与轻度认知功能障碍的关联[J]. 中华疾病控制杂志, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020
引用本文: 吴茵如, 钟逸诗, 高健, 陈沛良, 由芳菲, 宋玮琦, 毛琛. 老年人血浆IL-6、TNF-α水平与轻度认知功能障碍的关联[J]. 中华疾病控制杂志, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020
WU Yinru, ZHONG Yishi, GAO Jian, CHEN Peiliang, YOU Fangfei, SONG Weiqi, MAO Chen. Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020
Citation: WU Yinru, ZHONG Yishi, GAO Jian, CHEN Peiliang, YOU Fangfei, SONG Weiqi, MAO Chen. Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020

老年人血浆IL-6、TNF-α水平与轻度认知功能障碍的关联

doi: 10.16462/j.cnki.zhjbkz.2024.03.020
基金项目: 

国家自然科学基金 81973109

详细信息
    通讯作者:

    毛琛,E-mail:maochen9@smu.edu.cn

  • 中图分类号: R749.1+6

Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly

Funds: 

National Natural Science Foundation of China 81973109

More Information
  • 摘要:   目的  分析广东老年人(≥65岁)血浆白细胞介素-6(interleukin-6, IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)水平与轻度认知功能障碍(mild cognitive impairment, MCI)的关联。  方法  选取广东某社区卫生服务中心就诊的48例老年MCI患者作为病例组,96例无MCI的老年人作为对照组。采用logistic回归分析血浆IL-6、TNF-α水平与MCI的关联。绘制受试者工作特征(receiver operating characteristic, ROC)曲线评估血浆IL-6、TNF-α水平对MCI的诊断价值。  结果  共纳入144名老年人,其中48名MCI患者,63名男性(43.8%)。多因素logistic回归分析结果显示,血浆IL-6、TNF-α水平升高可使MCI患病风险增加,血浆IL-6、TNF-α水平每增高1个s,MCI患病风险分别增加53%和51%(OR=1.53, 95% CI: 1.02~2.29, P=0.040; OR=1.51, 95% CI: 1.04~2.20, P=0.029)。血浆IL-6、TNF-α的ROC曲线下面积分别为0.60、0.64。  结论  血浆IL-6和TNF-α水平升高可能与≥65岁老年人MCI患病风险的增加有关。
  • 图  1  血浆IL-6、TNF-α水平诊断MCI的ROC曲线

    Figure  1.  ROC curve of plasma levels of IL-6 and TNF-α for the diagnosis of MCI

    表  1  研究对象基本特征

    Table  1.   Basic characteristics of the study subjects

    变量Variable 总人数 Total (n=144) 对照组 Control group (n=96) MCI组 group (n=48) χ2/Z值value P值value
    年龄/岁Age/years 72.0(69.0, 80.0) 72.5(69.0, 80.8) 71.5(69.0, 80.0) -0.117 0.907
    性别Gender 0.001 0.999
      男Male 63(43.8) 42(43.8) 21(43.8)
      女Female 81(56.2) 54(56.2) 27(56.2)
    婚姻状况Marital status 0.077 0.781
      在婚Married 110(76.4) 74(77.1) 36(75.0)
      其他Other 34(23.6) 22(22.9) 12(25.0)
    吸烟Smoking 0.054 0.817
      否No 134(93.1) 89(92.7) 45(93.8)
      是Yes 10(6.9) 7(7.3) 3(6.2)
    饮酒Drinking 0.030 0.862
      否No 125(86.8) 83(86.5) 42(87.5)
      是Yes 19(13.2) 13(13.5) 6(12.5)
    锻炼情况Exercise status 0.286 0.593
      是Yes 126(87.5) 85(88.5) 41(85.4)
      否No 18(12.5) 11(11.5) 7(14.6)
    高血压Hypertension 0.694 0.405
      否No 62(43.1) 39(40.6) 23(47.9)
      是Yes 82(56.9) 57(59.4) 25(52.1)
    糖尿病Diabetes 0.758 0.384
      否No 114(79.2) 74(77.1) 40(83.3)
      是Yes 30(20.8) 22(22.9) 8(16.7)
    冠状动脉粥样硬化Coronary heart disease 2.133 0.144
      否No 135(93.8) 88(91.7) 47(97.9)
      是Yes 9(6.2) 8(8.3) 1(2.1)
    脑血管病Cerebrovascular disease 0.414 0.520
      否No 139(96.5) 92(95.8) 47(97.9)
      是Yes 5(3.5) 4(4.2) 1(2.1)
    关节炎Arthritis 2.532 0.112
      否No 130(90.3) 84(87.5) 46(95.8)
      是Yes 14(9.7) 12(12.5) 2(4.2)
    IL-6/(ng·L-1) 13.87(11.05, 17.92) 13.41(9.80, 17.67) 14.93(11.96, 19.89) -1.973 0.049
    TNF-α/(ng·L-1) 302.78(195.19, 393.37) 265.42(190.71, 374.09) 375.80(236.85, 432.99) -2.712 0.007
    注:①以人数(占比/%)或M(P25P75)表示。
    Note: ① Number of people (proportion/%) or M(P25P75).
    下载: 导出CSV

    表  2  血浆IL-6、TNF-α水平与MCI的关联

    Table  2.   Association between IL-6, TNF-α and MCI

    变量Variable 人数Number of people 模型1 Model 1 模型2 Model 2 模型3 Model 3
    OR值value(95% CI) P值value OR值value(95% CI) P值value OR值value(95% CI) P值value
    IL-6/(ng·L-1)   144 1.43(0.99~2.07) 0.054 1.50(1.02~2.18) 0.039 1.53(1.02~2.29) 0.040
      <11.10 36 1.00 1.00 1.00
      11.10~<13.90 36 3.24(1.07~9.83) 0.038 3.22(1.04~9.97) 0.042 3.53(1.11~11.21) 0.032
      13.90~<17.90 36 3.30(1.07~10.14) 0.037 3.51(1.09~11.34) 0.036 3.37(1.02~11.17) 0.047
      ≥17.90 36 3.24(1.07~9.83) 0.038 3.54(1.13~11.03) 0.030 4.14(1.28~13.40) 0.018
      Ptrend 0.059 0.045 0.032
    TNF-α/(ng·L-1) 144 1.43(1.01~2.04) 0.047 1.51(1.05~2.17) 0.025 1.51(1.04~2.20) 0.029
      <194.20 36 1.00 1.00 1.00
      194.20~<297.20 36 0.72(0.23~2.22) 0.566 0.75(0.24~2.36) 0.627 0.68(0.21~2.18) 0.519
      297.20~<391.88 36 2.13(0.77~5.91) 0.145 2.45(0.85~7.03) 0.096 2.26(0.76~6.70) 0.142
      ≥391.88 36 2.67(0.98~7.28) 0.055 2.99(1.07~8.34) 0.037 3.13(1.09~8.97) 0.034
      Ptrend 0.013 0.008 0.008
    注:模型1,调整年龄、性别;模型2,在模型1的基础上进一步调整婚姻状况、吸烟、饮酒、锻炼;模型3,在模型2的基础上进一步调整高血压、糖尿病、冠状动脉粥样硬化、脑血管病及关节炎患病情况。
    Notes: Model 1, adjusting for age, gender; Model 2, on the basis of model 1, marital status, smoking, drinking, exercise were adjusted; Model 3, on the basis of model 2, hypertension, diabetes, coronary heart disease, cerebrovascular disease, arthritis were adjusted.
    下载: 导出CSV

    表  3  血浆IL-6、TNF-α水平对MCI的诊断价值

    Table  3.   Diagnostic value of plasma levels of IL-6 and TNF-α for MCI

    变量Variable AUC 95% CI P值value 诊断临界值/(ng·L-1)Cut-off point/(ng·L-1) 约登指数Youden index 灵敏度/%Sensitivity/% 特异度/%Specificity/%
    IL-6/(ng·L-1) 0.60 0.51~0.69 0.049 11.31 0.24 87.50 36.50
    TNF-α/(ng·L-1) 0.64 0.54~0.74 0.007 353.86 0.32 62.50 69.80
    下载: 导出CSV
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出版历程
  • 收稿日期:  2023-08-29
  • 修回日期:  2024-01-10
  • 网络出版日期:  2024-04-08
  • 刊出日期:  2024-03-10

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