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CN 34-1304/R ISSN 1674-3679

2016 Vol. 20, No. 7

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Relationship between carotid intima-media thickness and glycemic control among type 2 diabetes mellitus patients
CAO Ya-ying, SUN Ke-xin, XIANG Xiao, LIU Zhi-ke, JUAN Juan, YANG Cheng, QIAN Jie, YANG Chao, SONG Jing, HUANG Shao-ping, LIU Xiao-fen, LI Na, TANG Xun, LI Jing, WU Tao, CHEN Da-fang, HU Yong-hua
2016, 20(7): 647-651. doi: 10.16462/j.cnki.zhjbkz.2016.07.001
Abstract(360) PDF(43)
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Objective To explore the relationship between carotid intima-media thickness (CIMT) and glycemic control in community type 2 diabetes mellitus (T2DM) patients. Methods A community-based study for T2DM patients aged over 40 years was conducted in three rural communities in Beijing. Every participant underwent hemoglobin A1c (HbA1c) assessment, CIMT measurement, physical examination, biochemical test and a questionnaire investigation. According to the level of HbA1c, T2DM patients were divided into well-controlled group, moderately controlled group and poorly controlled group and then the association between CIMT and glycemic control among T2DM patient was analyzed. Results A total of 720 T2DM patients were recruited. The average age was 59.06±7.50 years old and the mean T2DM duration was 6.3 years. Correlation analysis showed CIMT was positively associated with HbA1c (rs=0.182, P<0.001). The thickness increase rate of CIMT for well-controlled (HbA1c<6.5%), moderately controlled (6.5%≤HbA1c<8.0%), and poorly controlled (HbA1c≥8.0%) groups were 21.98%, 28.94% and 38.11% respectively (χ2=13.78, P=0.001). Logistic regression analysis showed that after adjusting for age, sex, cardio-cerebral vascular disease history, anti-diabetic drug use, T2DM duration, indexes of blood pressure and lipids, the thickness increase rate of CIMT was associated with HbA1c (OR=1.18,95% CI:1.07-1.31). Compared with the well-controlled group, poor glycemic control remained a risk factor for the elevation of CIMT (OR=2.17, 95% CI:1.34-3.51). Conclusions The level of glycemic control among T2DM patients was associated with CIMT. Poor glycemic control (HbA1c≥8.0%) might be a risk factor for the development of atherosclerosis among T2DM patients and its function is independent of blood pressure and lipid level.
Analysis of the dyslipidemia and its influencing factors in the elderly with prediabetes in rural areas in Yiyang of Hunan
GAO Fan, XU Hui-lan, QIN Lu-lu
2016, 20(7): 652-655. doi: 10.16462/j.cnki.zhjbkz.2016.07.002
Abstract(446) PDF(38)
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Objective To investigate the prevalence and influencing factors of dyslipidemia in the elderly with prediabetes in rural areas in Yiyang. Methods The background characteritics and laboratory results of the elderly with prediabetes were collected by questionnaire and laboratory testing after screening prediabetes in rural areas during April to July 2015. Binary unconditional logistic regression was used to analyse the influencing factors of dyslipidemia among the elderly with prediabetes. Results The prevalence of dyslipidemia in the elderly with prediabetes in rural areas was 28.3% (95% CI: 24.2%-32.5%). The prevalence of males was 25.6% (95% CI: 19.1%-32.0%), and the prevalence of females was 30.3% (95% CI: 24.6%-36.0%). Results from the binary unconditional logistic regression indicated that increasing age, high body mass index, high waist to hip ratio, hypertension, smoking, lack of exercise, poor diet were risk factors of dyslipidemia in the elderly with prediabetes. Conclusions The prevalence of dyslipidemia in the elderly with prediabetes in rural areas in Yiyang is higher than that in general population. In order to control risk factors of dyslipidemia, and to reduce the incidence of dyslipidemia among this population, health monitoring and health education should be improved in future.
Analysis of the awareness of risk factors for hypertension and diabetes among urban community residents
ZHENG Xiao-guo, GUO Ai-li, SONG Yan, YIN De-lu, XIAO Feng, DING Xiao-yan, LI Rui-li, YIN Tao, YANG Hui-min, XIN Qian-qian, WANG Li-hong, CHEN Bo-wen, LIU Kai-tai
2016, 20(7): 656-658,662. doi: 10.16462/j.cnki.zhjbkz.2016.07.003
Abstract(594) PDF(37)
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Objective To understand the awareness of risk factors for hypertension and diabetes among urban community residents and it's influencing factors, in order to further provide basis and references for health education and health promotion based on community centers. Methods Fourteen community health service centers were selected from twelve provinces in China using convenience sampling method. Informed written consent was also obtained from all participants involved in this study. Results Of 6 620 residents, the higher age of community residents had the lower awareness rate of risk factors for hypertension and diabetes(χ2=131.382,P<0.001). The awareness rate was much higher among residents with hypertension or diabetes than those without disease (χ2=8.962, P=0.003). Moreover, multivariate Logistic analysis indicated that monthly family income, work status and suffering hypertension or diabetes were important determinants of the awareness. Conclusions The awareness rate of risk factors for hypertension and diabetes among community residents was low, and it's very crucial to strengthen the health education to elderly in community.
Analysis of the mental status and coping modes among elderly patients with chronic diseases
ZHANG Han, GUO Ji-zhi, WANG Rui-mei, ZHU Yu-hang, HU Shan-ju, ZHUANG Li-hui, DONG Yi, LUO Sheng
2016, 20(7): 659-662. doi: 10.16462/j.cnki.zhjbkz.2016.07.004
Abstract(1244) PDF(128)
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Objective To describe the mental health status of elderly patients with chronic diseases and identify associated influencing factors, also to evaluate the association between mental health status and coping modes and propose some suggestions to improve their mental health. Methods Self-designed questionnaire, self-reporting inventory (SCL-90) and simplified coping style questionnaire (SCSQ) were used to investigate the elderly patients with chronic diseases. Results 513 cases (40.6%) were screened as positive. Except interpersonal relationship sensitiveness, the scores of other factors were higher than the average score of normal Chinese people. Apart from marital status and residence areas, the other demographic characteristics, physical health indicators and economic variables were all influencing factors for SCL-90 scores. The correlation coefficient between positive coping mode and SCL-90 score was -0.120 (P<0.001), the correlation coefficient between negative coping mode and SCL-90 score was 0.131 (P<0.001). Conclusions The elderly patients with chronic diseases have serious psychological problems, its influencing factors are complex and their coping modes tend to be negative. Reasonable guidance is also needed to improve their mental health status.
The general mental health status and analysis on its related factors in adults of Changchun City
MA Yue, SU Ying-ying, YANG Guang, LIU Ying-yu, YOU Yue-yue, ZHANG Yang-yu, FU Ying-li, KOU Chang-gui
2016, 20(7): 663-666. doi: 10.16462/j.cnki.zhjbkz.2016.07.005
Abstract(307) PDF(34)
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Objective To understand the distribution characteristics and influencing factors of general mental health status in adults of Changchun City. Methods A 12-item general health questionnaire (GHQ-12) was used to estimate general mental health status in adults who were selected by the method of multi-stage and stratified random cluster sampling in Changchun City, and logistic regression was used to analyze related factors. Results The average score of GHQ-12 was 2.13 points, and the positive rate was 21.1% in adults of Changchun City. The positive rate was 25.6% in females and 16.6% in males, and the difference had statistical significance (χ2=72.078,P<0.001); Multivariate analysis showed that female(OR=1.509, 95% CI:1.248-1.824), marital status as widowed (OR=1.483,95% CI:1.103-1.995), sleep time less than seven hours (OR=1.586, 95% CI:1.334-1.885) or more than nine hours(OR=1.322, 95% CI:1.003-1.743), type of occupation as others(OR=1.245, 95% CI:1.002-1.547), and suffered with chronic diseases(OR=2.130, 95% CI:1.760-2.578) were risk factors of mental health; Age above 35 years old(OR=0.540, 95% CI:0.361-0.808; OR=0.497, 95% CI:0.328-0.752; OR=0.425, 95% CI:0.276-0.656; OR=0.526, 95% CI:0.325-0.852), monthly average income per family over 500 yuan(OR=0.656, 95% CI:0.519-0.829; OR=0.571, 95% CI:0.445-0.732; OR=0.567, 95% CI:0.432-0.761; OR=0.519, 95% CI:0.366-0.737), regular dietary (OR=0.584, 95% CI:0.485-0.704), and physical exercises (OR=0.583, 95% CI:0.480-0.709; OR=0.789, 95% CI:0.642-0.971) were the protective factors of mental health. Conclusions Mental health status of adult residents in Changchun City was poorer. Appropriate measures should be taken by relevant departments to improve the basic quality of life of residents, and combined with lectures and other activities to increase their health care consciousness.
Study on the evaluation of the physiological aging and detection of telomere length in healthy community people
DENG Peng-fei, ZHOU Xuan, LONG Yao, ZENG Ni, LIN Fei, ZHONG Ai-ling, HUANG He-lang
2016, 20(7): 667-669,686. doi: 10.16462/j.cnki.zhjbkz.2016.07.006
Abstract(352) PDF(34)
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Objective To explore the change trends of telomere length in peripheral blood leukocyte with age and physiological aging in healthy community people and provide basic evidence and reference for aging evaluation. Methods Stratified random sampling was used to investigate healthy residents beyond 20 years old who lived in Nanchang. Quantitative real-time PCR technology was used to measure telomere length. Results A total of 1 000 questionnaires were distributed and 986 of them were valid after serious confirmation(98.60%). The ratio of male to female was 0.97:1. There was no significant difference in gender distribution (t=1.319, P=0.995). There was a positive correlation between aging scores and age(r=0.892, P<0.001).The result of telomere length showed that the average relative telomere length was(1.057±0.031).Telomere length of old, middle and young people were significantly different (F=586.930, P<0.001). Telomere length was negatively correlated with age(r=-0.814,P<0.001) and physiological aging scores(r=-0.682,P<0.001). Conclusions The established physiological aging index system which based on literature review and expert consultation showed that the score of physical aging and its three aspects increased with age and telomere length is negatively correlated with aging scores.
Characteristics of unintentional and intentional injuries among children from emergency and outpatient rooms in China, 2006-2014
WANG Yuan, YE Peng-peng, Duan Lei-lei
2016, 20(7): 670-674,743. doi: 10.16462/j.cnki.zhjbkz.2016.07.007
Abstract(341) PDF(36)
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Objective To explore characteristics of unintentional and intentional injury among children aged 0-17 in China. Methods Data collected from National Injury Surveillance System through 2006 to 2014 were analyzed. Results The proportion of intentional injuries was declining through 2006 to 2014. Among cases collected in 2014, unintentional injury and assault were higher in boys, while self-harm was similar between boys and girls. The top three causes were falling, road traffic injury and blunt injury for unintentional injury, poisoning, sharp injury and falling for self-harm, blunt injury, sharp injury and animal injury for assault. The top location injury occurred were home for unintentional injury and self-harm, while school and public place was the top one for assault. Proportion of moderate and severe injuries among self-harm were higher than that in unintentional injury and assault. There were differences between different gender and age. Conclusions It's necessary to have a good understanding of child injuries for prevention.
Investigation on the status of injuries among 2 564 migrant children aged 2-16 years old
XIAO Dan-qiong, WEI Qian-wei, ZHANG Cui-hong, LIU Xiao-li, LI Zhi-wen, WANG Xiao-li
2016, 20(7): 675-678. doi: 10.16462/j.cnki.zhjbkz.2016.07.008
Abstract(333) PDF(30)
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Objective To investigate the status of injuries among migrant children in Yamenkou community, Shijingshan district, Beijing. Methods A self-designed questionnaire was developed and administered to parents of migrant children. Results The incidence of injury among 2 564 migrant children aged 2-16 years old was 38.1% with total 976 children injured 1 490 times before June,2015. Children aged 3-6 years old had high-risk for injury. Of all the injuries observed, falls and bumps were the leading causes of injury (31.1%), followed by burns and scalds (20.7%), animal bites (19.5%). The rate of medical treatment after injury was 82.4%. The incidence of injured children whose parents with primary education was the highest(χfathers2=19.01, P<0.001;χmothers2=20.28, P<0.001). Conclusions The migrant children have high rates of injuries. Increased nursing, especially mother's education level and safe consciousness should be improved to provide a safer living environment for migrant children.
An analysis of sport injuries status and risk factors in rural school children in Fenggang County
HUI Ya, YANG Hua-jun, SHI Shang-peng, CAO Bo-ling, QI Yong-hong, SHI Xiu-quan
2016, 20(7): 679-682. doi: 10.16462/j.cnki.zhjbkz.2016.07.009
Abstract(318) PDF(31)
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Objective To explore the situation of the sports-related unintentional injuries of the school-aged children in Fenggang county, Zunyi city, and to provide the basic evidence for the sports injury prevention strategy. Methods A total of 465 students from primary and secondary schools of grade 4 to grade 7 were recruited by multi-stage cluster random sampling, then self-designed questionnaires of children sports injuries were used to conduct a survey to collect the condition about general characters, family, school situation, sports injuries in a recent year and related knowledge about sports injuries. Results The unintentional injury annual incidence of school children in Fenggang county was 18.71%, and boys was higher than girls(22.63% vs 14.41%). The highest incidence of the children's sports injuries was 29.28% in Grade 7; the lowest was 7.76% in Grade 5. The incidence of injuries in the left-behind children was significantly higher than that in un-left-behind children(22.26% vs 12.20%). The incidence of injuries of boarder was significantly higher than day pupils(24.53% vs 13.83%).The main injury action was running(33.33%). The main types of injuries were bruises(40.23%). Multivariate Logistic regression analysis showed that “not warm up before exercise”(OR=3.834,95% CI:1.362-10.792),“without accompany”(OR=2.403,95% CI:3.742-30.616),“movement in the concrete board”(OR=4.175,95% CI:1.457-11.964) and“leather shoes(OR=7.301,95% CI:1.736-30.705) or sandals(OR=4.316,95% CI:1.245-14.966)”were the risk factors for sports-related injuries. Except awareness rate on the item of “cold compress after a sprained” was higher in non-injured children than that of the injured children(χ2=5.36,P=0.021),there was no difference in other issues (all P>0.05). Conclusions The risk factors of sports injury is relatively clear among rural children in Fenggang country, and reasonable intervention measures should be taken to reduce sports-related injuries.
Mortality analysis on children under 5 years old in Lanzhou City from 2010 to 2014
LUO Bo-yan, LIANG Fang, ZHAO Li-ting, YANG Yan-jun, LI Zhi-lan
2016, 20(7): 683-686. doi: 10.16462/j.cnki.zhjbkz.2016.07.010
Abstract(318) PDF(35)
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Objective To understand the situation and main causes of children death under five years old in Lanzhou City from 2010 to 2014 and provide scientific basis for improving child health care to further reduce under-five mortality rate. Methods The death reporting categorized cards of children under five years old from 2010 to 2014 were used to analyze the distribution of age and causes of death, the potential years of life lost (PYLL) was assessed. Results The average mortality of children under five years old was 7.97‰ and neonatal death accounted for 69.61%. The top six leading causes of death were preterm delivery or low birth weight, birth asphyxia, congenital heart disease, other congenital anomaly, pneumonia and accidental death. The index of potential death caused by the top six leading causes were 71.73, 71.73, 71.42, 71.60, 71.64 and 69.47 respectively. The per PYLL of children under 5 years old was 71.44 (84157.94/1178). Conclusions We should actively control the main causes of children death under five years old, improve the construction of obstetrical and pediatrics department, and popularize the use of PYLL and the index of potential death in child care evaluation as early as possible.
The level of measles antibody pregnant Women in Anhui Province
ZHANG Ning, ZHOU Shu-jie, WANG Bin-bing, SU Ying, LIU Dan-qing
2016, 20(7): 690-693. doi: 10.16462/j.cnki.zhjbkz.2016.07.012
Abstract(353) PDF(30)
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Objective To evaluate serum levels of of measles antibody among pregnant women of Anhui province so as to provide evidence for measles control in infants younger than eight months. Methods Multistage sampling was adapted to select pregnant women who went to outpatient clinlc for prenatal examination from December 2013 to June 2014. They were asked to fill in a questionnaire. Blood samples were collected and centrifuged, serum was separated and tested for measles antibody levels with enzyme linked immunosorbent assay(ELISA). Results Of 1 141 pregnant women, the positive rate was 91.15% and the geometric mean concentration(GMC) was 572.03 mlU/ml for measles antibody IgG. The measles antibody IgG positive rate and GMC of urban pregnant women were higher than that of rural ones(all P<0.05). The measles antibody IgG GMC of elder pregnant women was higher than young ones(F=6.92,P<0.001). Conclutions Immunization of measles for child-bearing age women is a main measure for measles control in not only adults but also infants younger than 8 months.
A study on the status and influential factors of schistosomasis screening among middle school students in Hubei Province
PENG Min-jin, XIAO Han, GAO Meng-ting, XU Ya-yun, YAN Hong, LI Shi-yue
2016, 20(7): 694-697. doi: 10.16462/j.cnki.zhjbkz.2016.07.013
Abstract(357) PDF(39)
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Objective To understand the screening rate and its influential factors among middle school students in Hubei Province, so as to provide reference and suggestions for schistosomasis control among middle school students. Methods The schistosoma endemic regions were divided into transmission control area and epidemic control area in Hubei. A total of 3 204 middle school students were selected through stratified cluster random sampling and completed questionnaire. Results The prevalence of schistosomasis screening among middle school students was 62.5%. The prevalence were significantly different among students with different age, types of epidemic area, schistosomasis knowledge scores, level of fear for schistosomasis and health education frequencies (all P<0.05). Multivariance Logistic regression showed that types of epidemic area, schistosomasis knowledge scores and frequency of attending health education by staffs of school and schistosomasis control stations were influential factors. Conclusions The prevalence of schistosomasis screening among middle school students in Hubei Province is low. Health education in transmission control area, especially conducted by staffs of schistosomasis control stations may be effective strategy for improving the prevalence of schistosomasis screening among middle school students.
Study on the epidemiological characteristics of the natural focus and vector borne infectious disease and the strategy on prevention and control in Guiyang,1994-2013
TIAN Yong-qin, LU Chao-guo, WU Jia-hong
2016, 20(7): 698-702. doi: 10.16462/j.cnki.zhjbkz.2016.07.014
Abstract(289) PDF(30)
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Objective To analyze the epidemiological characteristics of the natural focus and vector borne infectious disease in Guiyang city and provide the evidence for prevention and control of these diseases. Methods Descriptive epidemiological analysis and dynamic series were conducted to analyze the epidemiological characteristics and the variation tendency based on the incidence data of natural focus and vector borne infectious disease reported in Guiyang from 1994 to 2014. Results A total of 4 317 cases and 11 diseases were reported during 1994-2013 in Guiyang. The average incidence was 0.39-33.84/105 which showed a decline trend; a total of 323 deaths were reported and the mortality was 0.00-1.23/105 ; the incidence was higher in the suburban district than in the downtown for the diseases of epidemic hemorrhagic fever, epidemic encephalitis B, anthrax, eptospirosis and epidemic and endemic typhus(χ2＝4 548.679,P<0.001).They were peak seasons in June to August and October to next January per year; The main incidence was distributed among farmer, students and scattered children, constituent ratio in student and farmer worker was increased and that in farmer was significantly decreased in the recent ten years. Conclusions The overall incidence of natural focus and vector borne infectious diseases in Guiyang is in decline,and the diseases have obvious district distribution, seasonality and population distribution. It is necessary to conduct targeted prevention and control of these diseases.
Application of nephrogram in the HD-MTX chemotherapy of children with intermediate/high risk acute lymphoblastic leukemia
XIE Zhi-wei, LIU Kang-kang, YANG Lin-hai, WANG Yan-chu, JIN Hua, WANG Ning-ling
2016, 20(7): 703-706. doi: 10.16462/j.cnki.zhjbkz.2016.07.015
Abstract(399) PDF(28)
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Objective To investigate the application of nephrogram in HD-MTX chemotherapy among children with intermediate/high risk acute lymphoblastic leukemia. Methods A retrospective comparative study was conducted. A total of 304 patients was included. According to whether the nephrogram checks before the first HD-MTX chemotherapy was given, the patients were divided into group A and B. Patients in group A were adjusted MTX chemotherapy dose based on nephrogram findings. The two groups' gastrointestinal reactions, mucositis, side effects of liver damage, bone marrow suppression, infection, MTX concentration range, as well as CF rescue dose (CF/MTX) were compared.Results Thedifferences of the two groups' gastrointestinal reactions(χ2=92.809,P<0.001), mucositis(Z=4.257,P<0.001), infection(χ2=7.352,P=0.007), as well as MTX concentration range(χ2=35.553,P<0.001), as well as CF rescue dose (CF/MTX)(χ2=35.526,P<0.001)were statistically significant. Conclusions Intermediate/high risk ALL children should be given nephrogram examination beforeHD-MTX chemotherapy and dose of MTX should be individualized. In these ways, the effective concentration of the MTX can be ensure, at the same time, the side effects of MTX chemotherapy and the rescue dose of leucovorin can be reduced.
Association of IL-28B rs12979860 with spontaneous HBV clearance and interferon treatment response: a Meta-analysis
YU Feng-xue, JIANG Le, MA Ning, ZHANG Xiao-lin, QUAN Yuan, LIU Dian-wu
2016, 20(7): 707-711. doi: 10.16462/j.cnki.zhjbkz.2016.07.016
Abstract(247) PDF(24)
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Objective To investigate the association of SNP-rs12979860 in Interleukin- 28B (IL-28B) gene with spontaneous Hepatitis B Virus (HBV)clearance and interferon treatment response in patients with chronic hepatitis B. Methods Data published from January 1, 2010 to August 31, 2015 were retrieved from PubMed,Embase,CNKI,Wan-fang database,VIP database and CBM disc. The meta-analysis was performed to analyze the data. Results Twelve papers were obtained and were divided into two groups according to the purpose of the study. Group A included five articles about rs12979860 and spontaneous HBV clearance, and group B included nine articles about rs12979860 and interferon treatment response. The meta-analysis showed that there was no association between rs12979860 and spontaneous HBV clearance (OR=0.96,95% CI:0.76-1.20,P=0.700) and the response after interferon treatment for HBeAg-positive patients (OR=0.93, 95% CI:0.43-2.00,P=0.848), respectively. There was positive correlation between rs12979860 and the response after interferon treatment for HBe-negative patients, which manifested that the mutant genotype TC+TT significantly reduced the response after interferon treatment for HB e-negative patients. (total OR=0.47, 95% CI:0.25-0.87,P=0.016). Conclusions The mutant genotype TC+TT located on rs12979860 from gene IL-28B reduced the response after the interferon treatment for HBe-negative patients.
Immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose:a Meta-analysis
CHENG Xiao-hua, WANG Shi-yuan, LIU Yuan-bao, YANG Wei-wei, Liu Pei
2016, 20(7): 712-716. doi: 10.16462/j.cnki.zhjbkz.2016.07.017
Abstract(433) PDF(33)
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Objective To systematically review the immunization efficacy of Japanese encephalitis live attenuated vaccine booster dose among children. Methods Databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library were searched for studies on Japanese encephalitis live attenuated vaccine booster dose. According to the inclusion and exclusion criteria, individual studies were selected by reviewing literatures. Data were aggregated and methodological quality of primary studies was assessed. Meta-analysis was performed using Stata 12.0. Results Nine studies were included in the final meta-analysis. Results showed that the pooled positive rate was (79%; 95% CI: 69%-90%) after the first vaccination and decreased sharply one year later (51%; 95% CI: 17%-86%)). The pooled positive rate increased significantly after a booster dose (98%; 95% CI: 97%-99%). Conclusions Positive rate and GMT of among intervals between first vaccination, one year after first vaccination and booster dose are statistically significant. A booster dose provides better protection against Japanese encephalitis with a higher serological effect.
Analysis of the co-expression of MYC/Bcl-2 in prognosis of diffuse large B cell lymphoma
YANG Fan, QIAN Shen-xian, ZHAO Yi-fei, AN Na
2016, 20(7): 717-720,724. doi: 10.16462/j.cnki.zhjbkz.2016.07.018
Abstract(380) PDF(26)
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Objective To analyze the relationship between co-expression of MYC/Bcl-2 proteins and clinical features and prognosis of diffuse large B-cell lymphoma(DLBCL), so as to explore the significance of MYC/Bcl-2 protein co-expression in DLBCL. Methods The immunohistochemical examination of MYC/Bcl-2 protein expression was conducted for lymphoma tissue samples of 89 cases of DLBCL patients who were pathologically confirmed. Next, a single factor comparison with progression free survival was made to such factors as whether to apply rituximab, primary sites,ages,genders,Ann Arbor stage,international prognostic index,immunohistochemistry Hans typing, Ki-67 expression and MYC/Bcl-2 protein co-expression. Then the factors having a statistically significant difference were included for multi-factor regression analysis. Results There were 29 cases of MYC/Bcl-2 co-expression patients, accounting for 32.6%. Through single factor comparison, the factors of whether to apply rituximab, age> 60 years, stages Ⅲ-Ⅳ, international prognostic index =3-5 scores, and MYC/Bcl -2 coexpression were adverse prognostic factors (all P<0.05); and the factors of whether to apply rituximab, age>60 years, stages Ⅲ-Ⅳ, international prognostic index=3-5 scores, and MYC/Bcl-2 co-expression had statistical significance (all P<0.05) through multi-factor regression analysis. Conclusions MYC/Bcl-2 co-expression is an independent prognostic risk factor for DLBCL.
Analysis of clinical factors influencing pathologic diagnosis in lymphoma
CHEN Wen-jun, SONG Geng, LI Ze-qing, WU Xiu-wei, LI Chang-zheng, WANG Nian-fei, WU Qiang, CHEN Zhen-dong
2016, 20(7): 721-724. doi: 10.16462/j.cnki.zhjbkz.2016.07.019
Abstract(404) PDF(28)
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Objective To explore factors influencing the discrepancy between clinical and pathological lymphoma diagnosis and their effects on the lymphoma treatment. Methods 232 hospitalized patients clinically or pathologically diagnosed with lymphoma between January 1st, 2012 and December 31st, 2014 were included in this study. The discrepancy between clinical and pathological diagnosis was assessed and the effects on the lymphoma treatment was evaluted. Results The diagnostic reliabilities of nodal lymphoma and diffuse large B-cell lymphoma were higher than those in extra-nodal lymphoma and non-diffuse large B cell lymphoma respectively. Reliability of pathological diagnosis was affected by diagnostic methods whereby the highest reliability incision biopsy could be 73.7%. There were 14(6.0%) inconsistent cases between clinical and pathological diagnosis, three cases resulted in moderate effects and 11 cases lead to mild effects on treatment. Inconsistencies were mainly due to lesion locations, different pathological diagnostic methods and pathological types of lymphoma. Conclusions The difficulty of lymphoma diagnosis, the locations and pathological diagnostic methods of lymphoma may contribute to the discrepancy between clinical and pathological diagnosis of lymphoma. Effective communication between clinicians and pathologist is required to get a more accurate diagnosis of lymphoma.
Clinical and laboratory predictors of pathological classification of lupus nephritis
WANG Fen, XU Jian-hua, CAI Jing-yu, TANG Hua-yang, WU Yong-gui, LU Wen
2016, 20(7): 725-728,733. doi: 10.16462/j.cnki.zhjbkz.2016.07.020
Abstract(283) PDF(28)
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Objective To establish a relative predictive model of pathology of lupus nephritis based on clinical and laboratory results. Methods Lupus nephritis patients who had renal biopsies were consecutⅣely recruited in our hospital from 2011 to 2015. 201 patients had already received an over two months treatment with glucocorticoid, but they still had positive proteinuria. The clinical manifestations and laboratory indexes of these patients were analyzed. Epi Data 3.1 and SPSS 21.0 were used for statistical analysis. Results Seventeen cases with class Ⅱ lupus nephritis, 26 cases with class Ⅲ lupus nephritis, 135 cases with class iv lupus nephritis and 23 cases with classⅤ lupus nephritis. In single analysis, patients with proliferative lupus nephritis were younger and had earlier first-onset age, higher SLEDAI, more anemia, lower serum levels of C3 complement components, higher positive rate of anti-C1q antibody (64.0%) and anti-dsDNA antibody (53.4%). Patients with membranous lupus nephritis had older first onset age and lower positive rate of anti-dsDNA antibody (13.0%). Proteinuria turned negative rate was 67.4% in the supine position in patients with mesangioproliferative lupus nephritis. In logistic regression anlysis, patients with mesangioproliferative lupus nephritis had lower SLEDAI and higher incidence of disappearance of the protein loss in the supine position. Patients with proliferative lupus nephritis had higher SLEDAI, positive rate of proteinuria and anti-dsDNA antibody. Patients with membranous lupus nephritis had later first-onset age and lower positive rate of anti-dsDNA antibody. Conclusions The predictive model of pathological classifications of lupus nephritis has been established. Lower SLEDAI and higher incidence of negative proteinuria test in the supine position could be the strong predictors for class Ⅱ lupus nephritis. Higher SLEDAI, positive rate of proteinuria and anti-dsDNA antibody may predict class Ⅲ or iv lupus nephritis. Later first-onset age and lower positive rate of anti-dsDNA antibody may predict class Ⅴ lupus nephritis.
The application of multiple imputation and multilevel model in longitudinal follow-up data
WU Qiu-hong, ZHANG Pi-de, ZHOU Guo-mao, LUO Zhen-zhou
2016, 20(7): 729-733. doi: 10.16462/j.cnki.zhjbkz.2016.07.021
Abstract(528) PDF(55)
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Objective To discuss how to deal with missing data and intra-class correlation in longitudinal follow-up data, and fully use the collected data to reflect the overall information.Methods Firstly, longitudinal complete data and missing data were simulated; Secondly, apply multiple imputation methods(MI) and multilevel model(MLM) were applied to deal with these data sets; Moreover, randomized block analyze of variance was used to analysis each data sets; Finally, an example was used to validate the simulation results.Results The results of different missing type coincided with those of different missing proportion: the deviation of MI with MLM was less than simple MLM. The more filling times, the smaller the deviation. As the missing rate increased, deviation of all methods became larger. The results got more stable in the present of large sample size. The simulation results were also verified by example analysis.Conclusions MI with MLM can provide effective and reasonable results in the longitudinal follow-up data.
Forecasting incidence of hepatitis A with ARIMA-GRNN hybrid model in China
WANG Yong-bin, LI Xiang-wen, CHAI Feng, YUAN Ju-xiang, YIN Su-feng, WU Jian-hui
2016, 20(7): 734-737,746. doi: 10.16462/j.cnki.zhjbkz.2016.07.022
Abstract(369) PDF(36)
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Objective To explore the application of ARIMA-GRNN hybrid model, ARIMA model and BPNN model in the prediction on incidence of hepatitis A in China and compare the predicative effect among them. Methods The data of incidence of hepatitis A from January 2004 to December 2014 in China was collected and SPSS 13.0 was used to construct ARIMA model, Matlab 8.0 was used to establish BPNN model and ARIMA-GRNN hybrid model, afterwards the data in 2014 was used to evaluate the effect of prediction. Results The average relative error of the three models, which was established to predict the incidence of hepatitis A sequence in China, fitness was 7.29785, 5.86174 and 4.91063 for ARIMA model, BP network model and ARIMA-GRNN hybrid model, respectively. The average relative error of accuracy predicted by ARIMA model, BP network model and ARIMA-GRNN hybrid model in 2014 was 6.44 067, 5.74 400 and 4.86 292, respectively. The results of other model evaluation indices, such as average error rate, mean square predict error and mean absolute error, also showed that ARIMA-GRNN hybrid model had the minimum error. Conclusions ARIMA-GRNN combination model is superior to the ARIMA model and BPNN model.
ARIMA model of measles incidence and its trend prediction from 2005 to 2014 in Nanning City
TANG Jin-fang, ZENG Xiao-yun
2016, 20(7): 738-740. doi: 10.16462/j.cnki.zhjbkz.2016.07.023
Abstract(373) PDF(35)
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A retrospective cohort study on the efficacy of varicella vaccine against varicella outbreak in school and kindergarten
WANG Cui-ling, LV Hai-ying, ZHOU Hai, SHU Bo, CAI Qian-chun, CHEN Xiao-hong
2016, 20(7): 741-743. doi: 10.16462/j.cnki.zhjbkz.2016.07.024
Abstract(257) PDF(23)
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Evaluation of health education on preventing tsutsugamushi disease in Taizhou City
HE Yi-lin, DAI Wen-jun, ZHANG Xiang, YI Qian-hua, QIAN Wei-juan, YIN Jun, ZHU Sai-jin, XU Zhen
2016, 20(7): 744-746. doi: 10.16462/j.cnki.zhjbkz.2016.07.025
Abstract(241) PDF(21)
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Current status and intervention of hand hygiene complicance among health care workers in a stomatological hospital of Hefei
ZHANG Jian-feng, LI Zhi-ju
2016, 20(7): 747-748,751. doi: 10.16462/j.cnki.zhjbkz.2016.07.026
Abstract(329) PDF(20)
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Strategies and evaluation of health epidemic prevention work after Nepal earthquake
ZHOU Chun-bei, ZHAO Jian, JI Heng-qing, SUN Jun, LI Zhi-feng, HE Ya-ming, XU Jia-wei
2016, 20(7): 749-751. doi: 10.16462/j.cnki.zhjbkz.2016.07.027
Abstract(172) PDF(23)
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Clinical efficacy of isotretinoin capsules combined with tanshinone capsules for moderate to severe acne
YAN Qun, DONG Xin-ya
2016, 20(7): 752-754. doi: 10.16462/j.cnki.zhjbkz.2016.07.028
Abstract(888) PDF(53)
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