Study on oxidative stress of liver in rats exposed to acetochlor

LI Long-xue; ZHENG Jing; XU Yi-hua; GENG Tian-qi; ZHANG Yang

doi:10.16462/j.cnki.zhjbkz.2016.01.014

Volume 20 Issue 1

Jan. 2016

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LI Long-xue, ZHENG Jing, XU Yi-hua, GENG Tian-qi, ZHANG Yang. Study on oxidative stress of liver in rats exposed to acetochlor[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(1): 54-57. doi: 10.16462/j.cnki.zhjbkz.2016.01.014

Citation:

LI Long-xue, ZHENG Jing, XU Yi-hua, GENG Tian-qi, ZHANG Yang. Study on oxidative stress of liver in rats exposed to acetochlor[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(1): 54-57. doi: 10.16462/j.cnki.zhjbkz.2016.01.014

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Study on oxidative stress of liver in rats exposed to acetochlor

doi: 10.16462/j.cnki.zhjbkz.2016.01.014

1. Department of Toxicology, School of Public Health, Harbin Medical University, Harbin 150081, China;
2. Department of Public Health Monitoring, Heilongjiang Center for Disease Control and Prevention, Harbin 150030, China

Received Date: 2015-10-27
Rev Recd Date: 2015-11-20

Abstract

Abstract

Objective To explore the effect of acetochlor on oxidative stress of livers in rats. Methods Wistar rats were randomly divided into low-dose group (17.18 mg/kg), high-dose group (107.40 mg/kg) and control group by weight. Rats were administered with acetochlor through continuous feeding and were sacrificed at the 12 w and 24 w after treatment, respectively. Spectrophotometric method and enzyme-linked immunosorbent assay were used to measure the content of total antioxidant capacity (T-AOC), reactive oxygen species (ROS), glutathione disulfide (GSSG) and glutathione (GSH) of livers. Results The ratios of liver weight and body weight in the high-dose group were all significantly different from those in the control group at the 12 w and 24 w(all P<0.05). At the 24 w, in high-dose and low-dose groups, the eosinophilic change of livers in rats was observed, and GSSG content and ROS level of livers were all higher than that in the control group (all P<0.05). Also the T-AOC level and GSH content of livers in high-dose group were all lower than those in the control group (all P<0.05). GSH redox potential of livers in rats increased significantly in high-dose group and low-dose group (all P<0.05), compared to the control. Conclusions Acetochlor could change the redox state of livers in rats and thus cause the oxidative stress, resulting in livers injury.
- Liver,
- Oxidative stress,
- Oxidation reduction

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References(18)

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