Current situation of drug resistance of 236 mycobacterium tuberculosis from Qinghai

Objective Through 236 strains of mycobacterium tuberculosis(M.tb) insolation and cultivation to explore drug resistance situation of mycobacterium tuberculosis which circulating in Qinghai area, so as to provide reference for TB prevention and control in this area. Methods A total of 236 strains of mycobacterium tuberculosis isolated in Qinghai were cultured with L-J medium.Drug resistance was tested by using the proportional method.The relationship between TB drug resistance and the demographic characteristics were analyzed. Results The results showed that drug resistance rate of 236 mycobacterium tuberculosis was 55.93% (132/236). Resistance rates of four first-line drugs from high to low were 43.22% for isoniazid, 38.14%for streptomycin, 37.29% for rifampin and 28.81% for ethambutol. MDR-TB and XDR-TB were 30.93% (73/236) and 1.27% (3/236) respectively. The ratio of SDR-TB was 12.71%. This drug-resistance TB were associated with regions and ages (all P<0.05), but were not associated with gender and ethnicity (all P>0.05). Conclusions The drug-resistance TB of Qinghai is higher than the national level.Measures of prevention and standardized treatment of tuberculosis patients should be strengthened in this area.