Gastroenteropancreatic neuroendocrine neoplasms:a clinical analysis of 97 cases

Objective To investigate the clinical characteristics, treatments and relationship with survival of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), so as to provide knowledge for further understanding of this disease. Methods The clinical data of the 97 GEP-NEN patients admitted in the First Affiliated Hospital of Anhui Medical University from December 2011 to December 2015 were retrospectively analyzed. Results Of the 97 patients, 64 cases were males and 33 were females,the male-to-female ratio was 1.9:1. There were 39 cases (40.2%) occurred in the stomach and 25 cases (25.8%) in rectum. Of all the 97 cases, non-functional symptom accounted for 95.9% (93/97), while functional symptom accounted only for 4.1% (4/97). The positive rate of immunohistochemical diagnosis of chromogranin A and synaptophysin were 87.6%, 96.9%, respectively. The multivariate analysis showed that risk factors of reducing survival rate include pathological grading,infiltrating extent and lymph node metastasis (all P<0.05), as well as surgical methods and gender (all P<0.05). Conclusions GEP-NEN may be found at any part of digestive system. Preoperative diagnosis is difficult and a lot of confirmed cases is already late. The treatment of this tumor mainly depends on the operation. The overall prognosis is good. The 1-and 3-year survival rates were 81.9% and 63.4%, respectively.