Impact of chronic hepatitis B and HBeAg status on maternal and infant outcomes

Objective To investigate the impact of chronic hepatitis B and hepatitis B e antigen(HBeAg) status on maternal and infant perinatal outcomes. Methods A total of 1 463 pregnant women with hepatitis B virus(HBV) who gave birth at Wuhan Women and Children Medical and Healthcare Center from June 2008 to September 2017. Additionally, 1 463 healthy pregnant women who delivered at the same hospital within a month (earlier or later) were selected as the control group, according to the intention of 1 control for every case. All subjects were divided into three groups:normal control group, hepatitis B surface antigen(HBsAg)(+) and HBeAg(-) group (single-positive group), HBsAg(+) and HBeAg(+) group(double-positive group). The pertinent information including general characteristics of pregnant women, pregnancy complications, and neonatal information were collected. The general characteristics and the occurrence of adverse maternal and infant outcomes of the above three groups were compared. Results Single-positive group (OR=2.74, 95% CI:1.09-6.90, P=0.033) and double-positive group (OR=6.67, 95% CI:1.29-34.48, P=0.023) both had higher risk of gestational hypertension. Also, single-positive group(OR=1.15, 95% CI:1.03-1.29, P=0.010) and double-positive group(OR=1.53, 95% CI:1.24-1.88, P<0.001) both had significantly higher rate of cesarean section. Conclusions Hepatitis B virus infection was associated with the higher risk of gestational hypertension and cesarean section.