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CN 34-1304/R ISSN 1674-3679

2018 Vol. 22, No. 6

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The advance of environmental stress and epigenetic transgenerational inheritance
CHEN Shen, LI Dao-chuan, CHEN Wen
2018, 22(6): 543-545. doi: 10.16462/j.cnki.zhjbkz.2018.06.001
Abstract(751) PDF(70)
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Epigenetic signatures can be modified in response to environmental influence. All of epigenetic markers can be almost erased by a two-step epigenome reprogramming progress during early development. However, epigenetic information and related phenotype occur in the absence of direct environmental exposure. It is called epigenetic transgenerational inheritance. Further study of epigenetic transgenerational inheritance will help us realize the profound influence of environmental factors on human health, and develop effective measures to prevent us from hazards. In this comment, we focus on epigenetic transgenerational inheritance and environmental stress and discuss the future of this area.
Association of single nucleotide polymorphism of AIF-1 gene and body mass index with susceptibility to oral cancer
BAO Xiao-dan, CHEN Fa, LIU Feng-qiong, YAN Ling-jun, WU Jun-feng, WANG Jing, WANG Rui, LIN Liang-kun, ZHENG Xiao-yan, CAI Lin, LIN Li-song, QIU Yu, HE Bao-chang
2018, 22(6): 546-550. doi: 10.16462/j.cnki.zhjbkz.2018.06.002
Abstract(420) PDF(40)
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Objective To explore the association of allograft inflammatory factor-1 (AIF-1) gene polymorphisms, body mass index (BMI) and their interactions with susceptibility to oral cancer. Methods A case-control study including 300 patients with pathologically confirmed oral cancer from September 2010 to December 2016 and 445 cancer-free controls was performed. The genotypes were determined by TaqMan genotyping assay. Unconditional Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) to assess the association of AIF-1 gene polymorphisms, BMI and their interactions with susceptibility to oral cancer. Results In the co-dominant genetic model(OR=0.522, 95% CI:0.319-0.855) and the recessive genetic model(OR=0.573, 95% CI:0.368-0.893), subjects carrying GG genotype of rs2857595 had significantly reduced risk of oral cancer, respectively. Moreover, GG genotype was a clear protective factor in male, individuals with BMI ≥ 24.0 kg/m2, and smoking and non-drinking subgroups. By contrast, BMI<18.5 kg/m2 was a risk factor of oral cancer, and BMI ≥ 24.0 kg/m2 reduced the risk of oral cancer. In addition, statistical analysis suggested an interaction between AIF-1 rs2857595 polymorphism and BMI. Conclusions This study suggests that AIF-1 rs2857595 polymorphism and BMI ≥ 24.0 kg/m2 may be protective factors for oral cancer. And there may be a multiplicative interaction between AIF-1 and BMI.
Predictors of breast cancer screening utilization among female at high risk of developing breast cancer: application of a Lasso Logistic model
CHENG Juan, LIANG Xuan, ZHENG Sen-shuang, WANG Jing, DING Lan-jun, WANG Yuan, LU Wen-li
2018, 22(6): 551-554,559. doi: 10.16462/j.cnki.zhjbkz.2018.06.003
Abstract(909) PDF(114)
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Objective To evaluate the application of a Lasso Logistic model for potential factors related with breast cancer screening among female at high risk of developing breast cancer. Methods A health risk appraisal model was used to measure women's objective risk of developing breast cancer. Lasso Logistic model was used to analyze the predictors of breast cancer screening utilization. Cross validation method was used to choose λ for Lasso Logistic model. In addition, the akaike information criterion (AIC) and bayesian information criterion (BIC) were chosen to evaluate the model fitting of Lasso Logistic model, compared with full Logistic model. Results Of the 771 women at high risk of developing breast cancer, 72.1% attended screening. The cross validation resulted in λ=0.044 for Lasso Logistic model. Age, education level, personal history of breast disease and breast self-examination were associated with breast cancer screening utilization in Lasso Logistic model and full Logistic model. AIC of Lasso Logistic model and full Logistic model were 762.44 and 762.73, respectively. And BIC were 785.68 and 804.55, respectively. Conclusions Lasso Logistic model was a sound fitting model for predictors of breast cancer screening utilization among women at high risk of developing breast cancer. Age, education level, personal history of breast disease and breast self-examination were predictors of breast cancer screening utilization.
Effects of smoking, drinking and dietary factors on hypertension in subjects with hyperuricemia
XING Hui-yuan, LIU Yan, ZHAO Ai, ZHENG Wei, LI Ting, ZHENG Ying-dong, WANG Yan, ZHANG Yu-mei
2018, 22(6): 555-559. doi: 10.16462/j.cnki.zhjbkz.2018.06.004
Abstract(860) PDF(57)
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Objective To investigate the relationship between hypertension in subjects with hyperuricemia (HUA) and smoking, drinking and dietary factors in China's adults, and provide evidence for the prevention and treatment of hyperuricemia and hypertension. Methods In 2016, questionnaires, body measurements and laboratory tests were conducted to investigate the relationship between diet and health status for adults from 8 Chinese cities. 334 subjects with hyperuricemia were divided into two groups based on their hypertension status:hypertension group (169 cases with hypertension) and control group (165 cases without hypertension).Multivariate Logistic regression analysis was conducted to explore the relevant factors. Results Serum uric acid level for female subjects in hypertension group was significantly higher than that in control group (t=3.374, P=0.001). Overweight or obesity accounted for 76.3% in hypertension group, and 53.3% in control group (χ2=21.512, P<0.001).For dietary nutrition, the energy from dietary fat in control group was higher than that in hypertension group (t=-2.416, P=0.016), while the energy from dietary carbohydrate was opposite (t=2.651, P=0.008). Multivariate logistic regression analysis showed that overweight, obesity, and appropriate vegetable intake were risk factors, while coffee drink and excessive meat intake were protective factors for hypertension in subjects with hyperuricemia. After adjusted for age and sex, multivariate Logistic regression indicated that only overweight (OR=2.06, 95%CI:1.14-3.71) and obesity (OR=4.55, 95%CI:2.11-9.81) were risk factors. Conclusions People should control their high SUA level first if they have already had HUA. In order to avoid hypertension, one should also pay attention to eat healthily to maintain weight and body mass index in good level.
Birthweight and subsequent risk of hypertension across two Chinese female generations
FANG Yuan, CHEN Ming-ling, FANG Hong, YAN Yu-jie, QIN Guo-you, YAO Bao-dong, Cecily Kelleher, XU Wang-hong
2018, 22(6): 560-564. doi: 10.16462/j.cnki.zhjbkz.2018.06.005
Abstract(366) PDF(38)
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Objective To evaluate the cross-generational associations of birthweight with subsequent risk of hypertension in Chinese women. Methods A cross-sectional study was conducted among 11 660 female residents with lineal blood relationship in Shanghai, China, from November 2012 to December 2016. Information on demographic characteristics, status at birth and lifestyle factors were collected. Body measurements were performed for participants aged over 20 years. Linear,no regression and path malysis were used to evaluated the strength of associations. Results Birthweight was not associated with blood pressure and hypertension in adulthood, with 1 kg increase in birthweight related to -0.2(-0.6-0.7), -0.3 (-0.6-0.2) and 0.3(-0.2-0.8) mmHg changes in systolic, diastolic and pulse pressures (all P<0.05). ORs and 95% CIs of hypertension in adulthood were 0.8 (0.5-1.2),1.0 (0.9-1.2), 0.8 (0.6-1.0) and 0.7 (0.4-1.2), respectively, for women with birthweight of <2.5, 3.0-, 3.5-and ≥ 4.0 kg relevant to those with birthweight of 2.5-kg. Path analysis showed positive correlations between maternal and daughters' birthweight, blood pressure and prevalence of hypertension (all P<0.05). The association between maternal birthweight and the risk of hypertension in daughters was not significant and was not mediated by daughters' birthweight. Conclusions Uteri nutrition may have no effect and intergenerational effect on blood pressure and the risk of hypertension in Chinese women.
The relationship between sleep quality and the risk of diabetes in hypertensive adults in northern coastal areas of China
BAN Qian-yun, WU Hong-xu, CHEN Lu-lu, MA Hai, ZANG Tong-hua, WANG Bin-yan, QIN Xian-hui, XU Xi-ping
2018, 22(6): 565-568. doi: 10.16462/j.cnki.zhjbkz.2018.06.006
Abstract(347) PDF(35)
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Objective To explore the relationship of sleep quality and the risk of diabetes in hypertensive adults in northern coastal areas of China. Methods The subjects of the study came from the epidemiological investigation conducted in Rongcheng, Shandong province from February to August 2017. Information on the subjects was collected through questionnaires and physical examinations. Multiple Logistic regression models were used to evaluate the relationship between sleep quality and diabetes. Results A total of 60 215 hypertensive adults were included in the final analysis. There were 9 353 hypertensive adults with diabetes and the prevalence rate was 15.5%. The proportions of good sleep quality, common sleep quality and poor sleep quality were 50.4%, 30.6% and 19.0%, respectively. Compared with participants with good sleep quality, the significantly higher risk of diabetes was observed in those with poor sleep quality (OR=1.09, 95% CI:1.03-1.16,P=0.005) after adjusting for relevant factors such as age and sex. Conclusions People with poor sleep quality have high risk of diabetes among hypertensive adults. Therefore, we should advocate good sleep habits such as early bedtime and early morning sleep to reduce the risk of diabetes.
Prevalence of diabetes mellitus and associated risk factors in population aged 35-74 years in Henan Province
LIANG Sen, HAN Bing, FAN Lei, FENG Hua-fei, GAO Li, ZHOU Gang, ZHANG Yu-hua, ZHU Wen-gang
2018, 22(6): 569-572,589. doi: 10.16462/j.cnki.zhjbkz.2018.06.007
Abstract(822) PDF(70)
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Objective To investigate the epidemiologic characteristics of diabetes mellitus in population aged 35-74 years in Henan Province, and to provide theoretical basis for tertiary prevention of diabetes. Methods The survey was conducted among the residents aged 35-74 years in Henan Province, they were selected through multi-stage cluster random sampling according to economic geography. Questionnaire survey, physical examination and biochemical tests were conducted to obtain the information of the subjects. Multivariate logistic regression model was performed to explore the risk factors of diabetes mellitus. Results A total of 9 983 adults were surveyed. The prevalence of diabetes mellitus was 11.22% for the entire population (standardized prevalence was 11.21%), while 11.83% (standardized prevalence was 11.77%) for males and 10.75% (standardized prevalence was 10.82%) for females, respectively. The prevalence of diabetes mellitus was increasing with age. The prevalence of diabetes mellitus in the 35 years-group in males was higher than that in females, while the in the 35-74 years group was lower. The differences were statistically significant (χ2=12.470,P<0.001; χ2=4.188,P=0.041). The results of multivariate logistic regression showed that age, gender, central obesity, hyperlipidemia, hypertension as well as family history were risk factors of diabetes mellitus (all P<0.05). Conclusions The prevalence of diabetes mellitus in population aged 35-74 years in Henan province was high. The unhealthy lifestyle and obesity were the major risk factors. It is necessary to strengthen the behavioral intervention in this part of the population, advocate a healthy lifestyle, limit alcohol consumption, prevent and control the occurrence of diabetes mellitus.
Effect of health management interventions on chronic diseases in the elderly
WU Xiao-li, XU Hui, YU Qing, WU Zhen-chun, WANG Fou, CHAO Jian-qian
2018, 22(6): 573-576,639. doi: 10.16462/j.cnki.zhjbkz.2018.06.008
Abstract(531) PDF(61)
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Objective To evaluate the effect of health management interventions on chronic diseases in the elderly and provide policy recommendations for the prevention and treatment of chronic diseases in the elderly. Methods The elderly over 60 years old who received the physical examination in a community hospital in Nanjing were recruited. A total of 654 patients with hypertension or diabetes were selected. The patients were randomly divided into control group and management group. Health management interventions were conducted for 18 months in the management group, while the control group was under regular management without any interventions. Health status and the quality of life before and after the interventions were compared. Results The 18-month health management interventions were beneficial to the control of blood pressure and blood glucose in patients with chronic disease. Compared with the control group, the management group had an average decrease of (5.56±1.66) mmHg in systolic pressure control,(2.94±1.24) mmHg in diastolic pressure and (0.70±0.12) mmol/L in blood glucose,which were all statistically significant (all P<0.05). As for the quality of life, compared with the control group, the management group had an average increase of (0.81±0.06) points in the physical function scores, by (0.75±0.07) points in the psychological function scores, by (0.81±0.09) points in the social function scores, by (2.07±0.10) points in the diabetes-specific module and by (0.95±0.04) points in the quality of life scores. However, the score of the hypertension-specific module decreased by (0.67±1.12) points. The differences were all statistically significant (all P<0.05). The multilevel model showed that the quality of life of the management group increased by 0.03 points per month, and the quality of life of the control group decreased by 0.04 points per month in the management period. The quality of life of the elderly patients with chronic diseases has improved over time. Conclusions The implementation of health management is conducive to the control of blood pressure and blood sugar and has a positive effect on the quality of life in the elderly with chronic diseases.
Association between body mass index and depression among the Chinese elderly
LI Zhen, FU Chang, MAO Zongfu
2018, 22(6): 577-580. doi: 10.16462/j.cnki.zhjbkz.2018.06.009
Abstract(438) PDF(42)
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Objective To investigate the prevalence of depression among Chinese elderly and to explore the relationship between body mass index (BMI) and depression. Methods Our data were collected from the 2015 China health and retirement longitudinal study (CHARLS). 10 403 elderly participants aged 60 years and older from 450 village-level units and community units of 150 county-level units were selected in this study. Logistic regression was used to explore the relationship between BMI and depression. Results The prevalence of depression among Chinese elderly was 32.7%. Among the elderly men, after controlling the social demographic factors, healthy behavior, activities of daily living and other confounding factors, the overweight group (OR=0.728, 95% CI:0.593-0.893) and the obese group (OR=0.582, 95% CI:0.413-0.821) were associated with depression, when compared with the normal group. However, there was no significant relationship between underweight, overweight, obese and depression among elderly women (all P>0.05). Conclusions BMI is associated with depression only among elderly men in China, but this association did not exist among elderly women.
A study on the subjective well-being and its influencing factors of rural elderly living alone in one area of Anhui Province
REN Qiong-qiong, LI Jie, YU Dan-dan, ZHAO Dong-dong, DONG Bao, HUANG Yu-jun, QIN Qi-rong, CHEN Jian, SUN Ye-huan
2018, 22(6): 581-584. doi: 10.16462/j.cnki.zhjbkz.2018.06.010
Abstract(506) PDF(52)
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Objective To understand the current situation of subjective well-being (SWB) and its influencing factors of rural elderly living alone in one area of Anhui Province and to provide a theoretical basis for improving the subjective well-being of the elderly. Methods A total of 679 rural elderly living alone in one area of Anhui Province were selected by cluster sampling. They were surveyed by the memorial university of newfoundland scale of happiness, social support rating scale and a self-designed general questionnaire. Results The average score of SWB of 679 rural elderly living alone was (32.05±10.87) points, which was at the middle level. Multiple linear regression analysis showed that the SWB of rural elderly living alone was affected by monthly income, chronic diseases, physical exercise and social support. Monthly income was between 500 and 1 500 yuan (β=3.243, 95% CI:0.824-5.663), monthly income was more than 1 500 yuan (β=2.940, 95% CI:2.010-7.890), physical exercise (β=2.254, 95% CI:0.610-3.898), subjective support (β=1.314, 95% CI:1.029-1.600) and utilization of support (β=0.486, 95% CI:0.082-0.890) were positively associated with SWB. While chronic diseases (β=-3.586, 95% CI:-5.852——1.321) and objective support (β=-0.387,95% CI:-0.734——0.039) were negatively associated with SWB. Conclusions SWB of rural elderly living alone is affected by many factors. Special measures should be taken to improve the SWB.
Epidemiological characteristics and trend of scarlet fever in Shaanxi Province from 2010 to 2016
NING Shao-qi, CHEN Sa, CAO Lei, ZHOU Ti-cao, WANG Wei-hua, WANG Shu, ZHANG Yi
2018, 22(6): 585-589. doi: 10.16462/j.cnki.zhjbkz.2018.06.011
Abstract(481) PDF(43)
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Objective To understand the epidemic characteristics of scarlet fever in Shaanxi Province, to predict the incidence trend, and to provide scientific evidence for developing the reasonable prevention policy of the disease. Methods Descriptive epidemiologic method was used for analyzing the epidemic of scarlet fever in Shaanxi Province during 2010-2016, and the autoregressive integrated moving average model (ARIMA) was used to forecast the incidence of scarlet fever in 2017-2018. Results A total of 10 881 scarlet fever cases were reported in Shaanxi Province from 2010 to 2016, and the average annual incidence was 4.13/100 000. The ratio of male to female was 1.52:1, those aged from 3 to 7 years accounted for 72.3% of the total cases. The incidence was the highest in children aged 5 years, the average annual incidence rate in Guanzhong area was significantly higher than that in Shaanbei and Shaannan. Among them, Xi'an has the largest number of cases and the highest annual average incidence rate, most cases concentrated from April to June and from November to January. ARIMA model forecasting should that the incidence of scarlet fever in Shaanxi Province would remain high in 2017-2018. Conclusions Kindergartens and schools are the high-risk places of scarlet fever, hence preschool children, pupils and scattered children should be the key prevention and control objects. 2017 and 2018 are still a period of high morbidity of scarlet fever in Shaanxi Province. therefore surveillance and control should be continually strengthened in the main epidemic area.
Forecasting influenza like illness in Urumqi based on ARIMAX model
TUO Xiao-qing, ZHANG Zhan-lin, GONG Zheng, YELEDAN Mahan, HUANG Bing-xue, TIAN Tian, ABIDAN Ainiwaer, CHEN Zhen, GULISIYA Hailili, FAN Xu-cheng, DAI Jiang-hong
2018, 22(6): 590-593. doi: 10.16462/j.cnki.zhjbkz.2018.06.012
Abstract(772) PDF(49)
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Objective To explore the effect of auto-regressive integrated moving average model-X(ARIMAX) model on predicting influenza trend in Urumqi, and to provide basis for further application of modeling in forecasting infectious diseases. Methods Data on the number of influenza-like illness(ILI) cases and atmospheric particulate matter(PM2.5 and PM10) concentrations were collected from January 2013 to December 2016 in Urumqi. We used R to construct auto-regressive integrated moving average (ARIMA) model and predicted the number of ILI cases in the first 10 weeks in 2017 using ARIMAX model. Results From January 2013 to December 2016, the total number of ILI cases was 161 773 and the number of average weekly ILI cases was 777. The time series of ILI cases indicated that there was a high prevalence during winter and spring. ARIMA (1, 0, 0) model was established based on weekly ILI cases and akaike information criterion (AIC)=2 549.03. PM2.5 and PM10 were considered as parameters to build ARIMAX model (AIC=2 535.51) and they were shown to be statistically significant. Using iterative method to predict the data of the first ten periods (i.e. 10 weeks), the results indicated only 3 period (i.e. 3 weeks) prediction had the minimal error.The mean absolute percentage error (MAPE) of the two models was 12.019 74% and 12.014 17% respectively, suggesting both of them had a good predictive accuracy. Conclusions ARIMA model and ARIMAX model can predict trend of ILI cases incidence in short time and provide evidence for influenza monitoring and prevention.
Analysis on the epidemiological characteristics and temporal-spatial clusters of bacillary dysentery incidence in Chongqing from 2005 to 2015
WANG Xue, ZHANG Yan, XING Dian-guo, WEN Tong, MENG Qiu-yu, TANG Lu
2018, 22(6): 594-598,602. doi: 10.16462/j.cnki.zhjbkz.2018.06.013
Abstract(441) PDF(39)
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Objective To analyze the epidemiology and temporal-spatial clusters of bacillary dysentery in Chongqing from 2005 to 2015. Methods The monitoring data of bacillary dysentery in 38 regions were collected from 2005 to 2015, ArcGIS 10.2 software was employed to draw the spatial distribution map of bacillary dysentery incidence, OpenGeoda 1.2.0 was used to analyze the spatial correlation of bacillary dysentery incidence. Temporal-spatial clustering was employed by SaTScan 9.4.2. Results The annual incidence rate was 31.84/100 000 population from 2005 to 2015,with higher prevalence (43.7%) among people aged 1 to 5 years, the majority of bacillary dysentery cases were scattered children(41.75%). The peak season was between May and October. The bacillary dysentery incidence showed a spatial autocorrelation during study period, high-high clusters distributed in main urban districts, low-low clusters presented in the one-hour economic circle and Northeast Area. The temporal-spatial clustering analysis revealed that bacillary dysentery clusters most likely occurred in main urban districts from June to October. Conclusions The bacillary dysentery incidence present temporal-spatial clusters feature, and the prevention and control measures should be implemented in summer and fall and focused on main urban districts. Children, farmer and migrant workers are the key population to control the spread of bacillary dysentery.
Survey on infectious status of leptospira in rats of Fujian Province
XU Guo-ying, LIN Dai-hua, XIAO Fang-zhen, HAN Teng-wei, LIU Wei-jun, ZHOU Shu-heng, LIU Jing, DENG Yan-qin
2018, 22(6): 599-602. doi: 10.16462/j.cnki.zhjbkz.2018.06.014
Abstract(439) PDF(31)
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Objective To study the densit, species, infection rate and distribution of Leptosira of the host animals in Fujian Province, so as to provide a scientific basis for prevention and control of Leptospirosis. Methods From 2011 to 2016, fourteen areas were selected according to the epidemic of leptospirosis in Fujian. Rats were captured with squirrel-cage method and their sera and organs were collected for pathogen culture and detection of antibody. Results A total of 1 312 rats were captured, whose rat density rate was 6.29%. And the rat density rates of 14 areas ranged from 3.25% (middle part of Fujian) to 9.98% (eastern part of Fujian). The Rattus losea, R.flavipectus, R. norvegicus and Niviventer fulvescens accounted for 87.57% of total rats. The distribution of rat species varied from area to area. Ten strains of Leptospira were isolated from the rat samples. The rat serum antibody positive rate was 26.42%, among which the Autumnalis and Java were major Leptosira (73.50%). Rat infection rates varied from area to area, ranged from 15.56% (middle part of Fujian) to 45.00%(northern part of Fujian). The highest infection rate of Leptospira were detected in R. flavipectus (35.53%), R. bowersi(31.58%) and Rattus losea (27.57%) respectively. Conclusions The distribution of rat species in Fujian was complex, and the dominant species were Rattus losea, R. flavipectus, R. norvegicus and Niviventer fulvescens. The infection level of rats was high, and the distribution of rat species and infection rate varied from area to area.
Epidemiologic characteristics and predictive analysis of other-infectious diarrhea in Baoji City from 2004 to 2016
HE Wei, LI Hong-bin, TIAN Hui, FU Hai-long
2018, 22(6): 603-606. doi: 10.16462/j.cnki.zhjbkz.2018.06.015
Abstract(369) PDF(35)
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Objective To analyze the epidemiological characteristics of other-infectious diarrhea in Baoji City from 2004 to 2016 and to provide scientific evidence for further prevention and developing control strategies. Methods Data were obtained from "Infectious Disease Report Information System in China", and the epidemiological characteristics of incidence distribution in Baoji City from 2004 to 2016 was analyzed. Results A total of 40 675 cases of other infectious diarrhea were reported from 2004 to 2016 years with the annual incidence of 84.09 per 100 000 population. The overall incidence of the amount of reported cases of other infectious diarrhea was on the rise, with a pandemic peak every four to five years. There were 62.47% of total reported cases were children aged 3 year-old. The highest incidence was found among scattered children,accounted for 63.01%. The main pathogen for viral diarrhea was rotavirus. Conclusions The incidence for other-infectious diarrhea in Baoji City is high, but the detection rate for laboratory-confirmed cases is low, the prevention and control of other infection diarrhea should be focused on scattered children.
Genetic characteristics analyses of the VP1 gene in coxsackievirus A16 isolates from Kunming in 2015
WEN Jie, WANG Peng-fei, LI Xiu-fang, CAO Xia
2018, 22(6): 607-612. doi: 10.16462/j.cnki.zhjbkz.2018.06.016
Abstract(549) PDF(54)
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Objective To study the molecular epidemiology of enterovirus associated with children hand-foot-mouth disease (HFMD) in Kunming from 2015 to 2016 and to explore the correlation between the genetic variation and spatial-temporal distribution pattern of coxsackievirus (CVA16) VP1 gene. Methods Throat swabs and rectal swabs were collected from children included in this study. Reverse transcription polymerase chain reaction was conducted to amplify the full-length VP1 gene of enterovirus 71 and CVA16. We randomly selected 9 CVA16 positive amplicons in 2015 for sequencing and these sequences were used to construct phylogenetic trees with relevant reference sequences from database. Correlation and regression analyses between genetic distances and the isolating times of CVA16 strains were performed. Mantel test between genetic distances and the geographical distances among geographical populations was also carried out. Results Most of the children were infected by CVA16 (the detection rate of throat swabs and rectal swabs were 29.41% and 15.69% respectively). The ratio of CVA 16 infection rate to enterovirus 71 infection rate was 2.5:1 and 2.0:1. Phylogenetic analyses of the VP1 gene proved that all the 9 CVA16 Kunming isolates belonged to genotype B, subgenotype B1b, and it can be further divided into two sub clusters. Phylogenetic and statistical analyses revealed a significant positive correlation between the genetic variation of CVA16 virus and both of the passage of time and geographical distance(all P<0.05). Conclusions The above results demonstrated that the 9 CVA16 isolates from Kunming, Yunnan Province, China in 2015, belonged to new mutant strains, suggesting its unique epidemic characteristic in Kunming city.
Association between F protein and negative costimulatory molecule 2B4 in chronic HCV infection
SHI Li-ping, LI Sen-sen, XIAO Wen, PEI Jia-ping, JI Xiao-wei, JIANG Long-feng, WANG Chang-jun, DENG Xiao-zhao, ZHANG Qi, HAN Yi-fang, ZHANG Jin-hai
2018, 22(6): 613-616,644. doi: 10.16462/j.cnki.zhjbkz.2018.06.017
Abstract(399) PDF(33)
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Objective To investigate the relationship between the production of hepatitis C virus (HCV) F protein and the negative costimulatory molecule 2B4 in chronic HCV infection. Methods The blood samples of chronic hepatitis patients (CHP) were collected and the positive rate of F antibody (F-Ab) was detected and divided into HCV-F(+) and HCV-F(-). Blood samples collected from healthy volunteers were used as control group. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured.The levels of interleukin 4 (IL-4),interferon γ (IFN-γ) before and after the blockade of 2B4 antibody were detected by enzyme-linkead immunosorbent assay. Results The levels of IFN-γ and IL-4 secreted in HCV patients were significantly higher than those in healthy controls (all P<0.05), and the level of IFN-γ secreted in HCV-F (-) group was significantly higher than that of HCV-F (+) group (F=1.908,P=0.020), while the level of IL-4 secretion was lower than that of HCV-F (+) group (F=1.342,P=0.009). After blocking with 2B4 antibody, the level of IFN-γ and IL-4 in healthy group had no significant change (all P>0.05). The level of IFN-γ in CHP group was significantly higher than that in the control group (F=1.214,P=0.003), and the levels in HCV-F (-) was higher than that of HCV-F (+) group (F=1.434,P=0.009). The levels of IL-4 were significantly lower than those before antibody block (F=1.505,P=0.015), and the levels in HCV-F (-) group were lower than those in HCV-F (+) group (F=1.444,P=0.032). Conclusions In chronic HCV infection, the signal regulation mechanism of F protein is correlated with negative costimulatory molecule 2B4.
Impact of chronic hepatitis B and HBeAg status on maternal and infant outcomes
CHEN Hong-yan, LI Xiu, PENG Song-xu, DU Yu-kai
2018, 22(6): 617-620. doi: 10.16462/j.cnki.zhjbkz.2018.06.018
Abstract(434) PDF(30)
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Objective To investigate the impact of chronic hepatitis B and hepatitis B e antigen(HBeAg) status on maternal and infant perinatal outcomes. Methods A total of 1 463 pregnant women with hepatitis B virus(HBV) who gave birth at Wuhan Women and Children Medical and Healthcare Center from June 2008 to September 2017. Additionally, 1 463 healthy pregnant women who delivered at the same hospital within a month (earlier or later) were selected as the control group, according to the intention of 1 control for every case. All subjects were divided into three groups:normal control group, hepatitis B surface antigen(HBsAg)(+) and HBeAg(-) group (single-positive group), HBsAg(+) and HBeAg(+) group(double-positive group). The pertinent information including general characteristics of pregnant women, pregnancy complications, and neonatal information were collected. The general characteristics and the occurrence of adverse maternal and infant outcomes of the above three groups were compared. Results Single-positive group (OR=2.74, 95% CI:1.09-6.90, P=0.033) and double-positive group (OR=6.67, 95% CI:1.29-34.48, P=0.023) both had higher risk of gestational hypertension. Also, single-positive group(OR=1.15, 95% CI:1.03-1.29, P=0.010) and double-positive group(OR=1.53, 95% CI:1.24-1.88, P<0.001) both had significantly higher rate of cesarean section. Conclusions Hepatitis B virus infection was associated with the higher risk of gestational hypertension and cesarean section.
Nutrition status of infants in a city of Zhejiang Province from 2002 to 2015
PU Liu-yan, CHEN Li, WANG Shuo-jia, JIANG Wen, HUANG Man-xian, LI Min-chao, JIANG Shu-ying, MO Min-jia, XIAMUSIYE Muyiduli, SHAO Bu-le, YU Yun-xian
2018, 22(6): 621-625. doi: 10.16462/j.cnki.zhjbkz.2018.06.019
Abstract(573) PDF(41)
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Objective To explore the nutritional status of young children in a city in Zhejiang from 2002 to 2015 and analyze potential influencing factors. Methods We used electronic medical recorder system and extracted maternal and offspring's medical information from the decoded database. Z-scores were used to elevate nutrition status. Logistic regression models were used to explore the influencing factors of the nutritional status. Results Among 48 827 children, the prevalence rate of underweight, stunting, thinness, overweight and obesity were 1.43%, 1.31%, 1.90%, 2.62%, and 0.34%, respectively. The prevalence of obesity had significant differences between genders(χ2=5.164,P=0.023). The prevalence of underweight was increased, and the prevalence of overweight and obesity were decreased. Furthermore, mother with higher educational level had lower risk of child's malnutrition, and mother with higher pre-pregnancy body mass index (BMI) had higher risk of child's overweight(OR=1.063, 95% CI:1.057-1.069,P<0.001) and obesity(OR=1.074, 95% CI:1.060-1.088,P<0.001); Maternal high-risk pregnancy was the risk factor of underweight (OR=2.214, 95% CI:1.928-2.542,P<0.001), stunting (OR=2.543, 95% CI:2.193-2.949,P<0.001) and thinness (OR=1.211, 95% CI:1.062-1.380,P=0.004) in children. Conclusions Overall, children's physical development in this city was in good condition. However, problems are still existing with malnutrition and overnutrition. Maternal high pre-pregnancy BMI, low educational level and high-risk pregnancy were independently related to child's malnutrition and overnutrition.
The relationship between pre-pregnancy body mass index, gestational weight gain and infants hemoglobin
WU Ming-lei, LI Rui, QIN Ruo-fang, LI Xiao-lan, WANG Li-li, BU Yang-gao, CAO Xiu-jing
2018, 22(6): 626-629. doi: 10.16462/j.cnki.zhjbkz.2018.06.020
Abstract(431) PDF(26)
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Objective To explore the relationship between pre-pregnancy body mass index (BMI), gestational weight gain and infants hemoglobin. Methods Mothers and infants who had regular physical examination were selected. General condition of mother and childbirth were collected by questionnaire. The statistical analysis was performed by univariate analysis and multivariate logistic regression model. Results Of all 980 subjects, 19.0% women were underweight, 71.0% with normal BMI, and 10.0% were classified as overweight or obesity according to their pre-pregnancy BMI. As the United States IOM standard, 27.8% women was less than the recommended value, while 31.4% were within it, but 40.8% exceeded institute of medicine (IOM) standard. The incidence of anemia was 49.7%. Univariate analysis showed that pre-pregnancy BMI and weight gain during pregnancy were statistically significant for anemia (all P<0.05). Multivariate analysis showed that pre-pregnancy emaciation (OR=2.027, 95% CI:1.433-2.867), insufficient gestational weight gain (OR=2.499, 95% CI:1.772-3.523) were risk factors for anemia in infants. Conclusions The pre-pregnancy BMI and gestational weight gain may be risk factors for infant anemia. Therefore, control of pre-pregnancy BMI and weight gain during pregnancy can effectively reduce risk of anemia.
Study on the relationship among depression and sleep quality of late trimester pregnant women
TIAN Yan-yan, TA Ming-hua, MA Ruo-mei, ZHANG Yan-ting, NIU Jian-mei, SHANG Yu-xiu
2018, 22(6): 630-634. doi: 10.16462/j.cnki.zhjbkz.2018.06.021
Abstract(548) PDF(50)
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Objective To investigate the current status of depression and sleep quality among pregnant women in the late pregnancy and its influencing factors, and to explore the relationship between depression and sleep quality in late pregnant women. Methods A total of 535 pregnant women were selected from 2 hospitals in Zhongwei city and the questionnaire survey were conducted, the quality of sleep and depression in pregnant women were evaluated using pittsburgh sleep quality index questionnaire (PSQI) and self-rating depression scale (SDS). Results Among the 535 pregnant women, 34.2% of them had depression symptoms, 20.6% of them had sleep disorder. The detection rate of sleep disorders in pregnant women with depression (29.0%) was higher than those among the pregnant women without depression (16.2%), and the difference was statistically significant (χ2=12.018, P=0.001). There was a positive relationship between the total score of PSQI and the score of SDS (r=0.680, P<0.001). Results of Multivariate logistic regression analysis showed that low level of education,poor relationship between husband and wife, pregnancy complications and sleep disorders were important risk factors of depressive symptom. Pregnancy complications, worry about children's health and depression were risk factors for sleep disorders in the late pregnancy. Conclusions There is a positive relationship between sleep quality and depression in late pregnant women, and comprehensive intervention measures should be taken to improve the depression and sleep quality of pregnant women in the late pregnancy.
Factors influencing BCG vaccine coverage among 1 999 children under two years of age
XIONG Yue-qiao, LIU Min, YAN Hong-mei, MA Jian, ZHANG Xiao-han
2018, 22(6): 635-639. doi: 10.16462/j.cnki.zhjbkz.2018.06.022
Abstract(287) PDF(27)
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Objective To investigate the vaccination coverage for Bacillus Calmette-Guerin(BCG) and its influencing factors among children aged 0-2 years old in Changying community of Beijing City, in order to provide reference and basis for improving the rate and the timeliness of BCG vaccination. Methods Prenatal data of mothers who were admitted to Changying community health service center and gave born between Jan. 2015 and Dec. 2016 in Beijing were collected, and BCG vaccination of the children was record. The Logistic regression analysis was carried out to determine factors influencing BCG vaccination rate and timely rate. Results The BCG vaccination rate of the children aged 0-2 years old in Changying was 98.8%, the timely vaccination rate was 86.84%. Born in 2016, preterm birth, low birth weight, cesarean delivery were risk factors that affect the vaccination rate of BCG. Preterm birth, low birth weight, perinatal complications, cesarean delivery were risk factors that affect the timely rate of BCG vaccination. Conclusions The rate and the timely rate of BCG vaccination about the children aged 0-2 years old in Changying community of Beijing City need to be improved. in these ways that Reinforcing the management of pregnant women and decreasing the perinatal complications can increase the vaccination coverage and the timeliness for BCG.
The relationship between age at menarche and pulse wave velocity and cardiovascular risk factors
WANG Jian-xiong, ZHANG Qiao, SHI Li-xin, PENG Nian-chun, ZHANG Miao
2018, 22(6): 640-644. doi: 10.16462/j.cnki.zhjbkz.2018.06.023
Abstract(279) PDF(25)
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Objective To explore the relationship between age at menarche and pulse wave velocity (PWV) and cardiovascular risk factors in postmenopausal women. Methods 2 682 natural postmenopausal women were selected from 7 330 women enrolled in Guiyang area survey 2011-2014. Those diagnosed diabetes and cardiovascular disease, premenopause and nonnatural menopause, age at menarche and menopause age information unclear were excluded. Through questionnaire, physical examination, serology and doppler ultrasound detection, the data of menarche age, body mass index (BMI), blood glucose, blood lipid, PWV and other indicators were obtained. The selected population was divided into 6 groups in accordance with the menarche age. All data were analysed by SPSS 20.0 software. Results Average menarche age in this group of people is (14.6±1.9) years. With the increase of menarche age, 6 groups of abnormal PWV rate was 88%, 76%, 71%, 75%, 76% and 80% respectively, and nearly u-shaped distribution trend (χ2=121.20, P=0.040), while the above indicators was the valley value of the u-shaped distribution in the menarche age of 14 to 15 age group. The risk factors of PWV were the menarche age, actual age, BMI, waist circumference, FPG, 2hPG, systolic blood pressure, diastolic blood pressure and triglyceride (all P<0.05). The influence of the menarche age on the abnormal risk of PWV was different in different generations. Conclusions The menarche age is related to pulse wave velocity and cardiovascular risk factors in aged over 40 natural postmenopausal women of Guiyang area.
Supportive care needs in patients with lung cancer in tertiary hospitals of Anhui Province
ZHANG Tian, LV Xiao-qing, HE Hong-ye, LIU Qun-hui, WU Dan, HONG Jing-fang
2018, 22(6): 645-647. doi: 10.16462/j.cnki.zhjbkz.2018.06.024
Abstract(332) PDF(27)
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Epidemiological surveillance of avian influenza virus in poultry trade area in Guangzhou during resting days
CAO Lan, LIU Yan-hui, CHEN Yi-yun, MA Yu, XIA Dan, LI Kui-biao, LU Jian-yun, DI Biao, LU En-jie
2018, 22(6): 648-650. doi: 10.16462/j.cnki.zhjbkz.2018.06.025
Abstract(302) PDF(33)
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The leader of public health campaign in Britain: John Simon
ZHAO Yu-lan, WU Jun, QIAN Liu-yu, YE Dong-qing
2018, 22(6): 651-652. doi: 10.16462/j.cnki.zhjbkz.2018.06.026
Abstract(592) PDF(42)
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John Simon (1816-1904) was an outstanding health official of British in 19th century. He committed to public health campaign in Britain as a medical expert.He created a set of public health work system, built national health and epidemic prevention system, promoted public health legislation, opened up scientific research in public health. His advanced public health concepts and practice accelerate the process of the history of global public health.

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