Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients

XIANG Zhi-sheng; LIN Zheng; LIU Shuang; YANG Hui-min; WANG Hang; HUANG Li-ping; CHEN Yuan-mei; HU Zhi-jian

doi:10.16462/j.cnki.zhjbkz.2019.02.003

Volume 23 Issue 2

Feb. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(2): 134-139

XIANG Zhi-sheng, LIN Zheng, LIU Shuang, YANG Hui-min, WANG Hang, HUANG Li-ping, CHEN Yuan-mei, HU Zhi-jian. Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(2): 134-139. doi: 10.16462/j.cnki.zhjbkz.2019.02.003

Citation:

XIANG Zhi-sheng, LIN Zheng, LIU Shuang, YANG Hui-min, WANG Hang, HUANG Li-ping, CHEN Yuan-mei, HU Zhi-jian. Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(2): 134-139. doi: 10.16462/j.cnki.zhjbkz.2019.02.003

Citation:

XIANG Zhi-sheng, LIN Zheng, LIU Shuang, YANG Hui-min, WANG Hang, HUANG Li-ping, CHEN Yuan-mei, HU Zhi-jian. Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(2): 134-139. doi: 10.16462/j.cnki.zhjbkz.2019.02.003

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Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients

doi: 10.16462/j.cnki.zhjbkz.2019.02.003

1.
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China
2.
Department of Thoracic surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University; Fuzhou 350014, China

Funds:

National Key R&D Program of China 2017YFC0907100

Medical Innovation project of Fujian Province 2018-CX-38

More Information

Corresponding author: Hu Zhi-jian, E-mail: hzj99955888@126.com
Received Date: 2018-08-14
Rev Recd Date: 2018-11-06
Publish Date: 2019-02-10

Abstract

Abstract

Objective To explore the effects of preoperative serum cancer antigen 19-9 (CA19-9) and neuron-specific enolase (NSE) on the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods This prospective study enrolled 176 patients with ESCC. χ² test was used to analyze the relationship between CA19-9, NSE and general clinical features. Survival curves were estimated using Kaplan-Meier method and comparisons were performed using the log-rank test. The Cox proportional hazards model was performed for multivariate analyses of overall survival (OS) and disease free survival (DFS). Results The patients with both high CA19-9 and NSE had the poor prognosis compared with those had both low CA19-9 and NSE (OS: HR=2.310, 95% CI: 1.208-4.418; DFS: HR=2.354, 95% CI: 1.265-4.381). Compared to the separate detection of the two markers, the combined detection of CA19-9 and NSE was more accurate in the prognosis prediction of patients with ESCC (OS: C-index=0.686; DFS: C-index=0.684). Conclusions Preoperative serum CA19-9 and NSE were risk factors for the prognosis of patients with ESCC. Combined detection had higher accuracy of prediction of prognosis in patients with ESCC.
- Esophageal squamous cell carcinoma,
- Cancer antigen 19-9,
- Neuron-specific enolase,
- Prognostic

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References(18)

References

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