Phylogenetic analysis of influenza B hemagglutinin and neuraminidase gene in Binzhou City from 2013 to 2018

ZHANG Li-fang; ZHANG Jing; SUN Hui; HUANG Ying; YIN Xiu-sheng; HAN Feng-chan

doi:10.16462/j.cnki.zhjbkz.2020.02.006

Volume 24 Issue 2

Feb. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(2): 151-154

ZHANG Li-fang, ZHANG Jing, SUN Hui, HUANG Ying, YIN Xiu-sheng, HAN Feng-chan. Phylogenetic analysis of influenza B hemagglutinin and neuraminidase gene in Binzhou City from 2013 to 2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(2): 151-154. doi: 10.16462/j.cnki.zhjbkz.2020.02.006

Citation:

ZHANG Li-fang, ZHANG Jing, SUN Hui, HUANG Ying, YIN Xiu-sheng, HAN Feng-chan. Phylogenetic analysis of influenza B hemagglutinin and neuraminidase gene in Binzhou City from 2013 to 2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(2): 151-154. doi: 10.16462/j.cnki.zhjbkz.2020.02.006

Citation:

ZHANG Li-fang, ZHANG Jing, SUN Hui, HUANG Ying, YIN Xiu-sheng, HAN Feng-chan. Phylogenetic analysis of influenza B hemagglutinin and neuraminidase gene in Binzhou City from 2013 to 2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(2): 151-154. doi: 10.16462/j.cnki.zhjbkz.2020.02.006

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Phylogenetic analysis of influenza B hemagglutinin and neuraminidase gene in Binzhou City from 2013 to 2018

doi: 10.16462/j.cnki.zhjbkz.2020.02.006

1.
Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264000, China
2.
Microbiological Laboratory, Binzhou Center for Disease Control and Prevention, Binzhou 256600, China

More Information

Corresponding author: HAN Feng-chan, E-mail:hanfengchan@gmail.com
Received Date: 2019-07-16
Rev Recd Date: 2019-10-10
Publish Date: 2020-02-10

Abstract

Abstract

Objective To investigate the mutation of hemagglutinin(HA), neuraminidase(NA) gene and amino acid variation of influenza B. Methods Throat swab specimens were taken from patient with influenza-like illness(ILI) and were investigated for the influenza virus identification from 2013 to 2018, and 29 strains of influenza B viruses were selected. HA, NA gene sequencing of the viruses were performed and were aligned using molecular evolutionary genetics analysis software. The phylogenetic tree was constructed. Results During the influenza seasons from 2013 to 2018, the detection rates of influenza B virus were 47.0%, 23.0%, 31.0%, 7.2% and 65.1%, respectively. Statistically significant differences between the proportion of influenza B viruses were observed(χ²=1 485.143, P < 0.001). The isolates from 2013 to 2014 did not correspond to vaccine strain, which was recommended by world health organization for the influenza season. Conclusions The evolution of influenza B virus was achieved through interlineal gene recombination, co-prevalence of different lineages, and continuous replacement of different antigenic lineages in Binzhou from 2013 to 2018.
- Influenza B virus,
- Hemagglutinin,
- Neuraminidase,
- Variation,
- Sequence alignment

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References(15)

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