Analysis on the factors that influence the treatment outcome of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province

WEI Wu-jia; MA Bin-zhong; WANG Chao-cai; JIANG Ming-xia; LI Er-chen; CHAO Xiu-zhen

doi:10.16462/j.cnki.zhjbkz.2020.03.008

Volume 24 Issue 3

Jun. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(3): 284-289

WEI Wu-jia, MA Bin-zhong, WANG Chao-cai, JIANG Ming-xia, LI Er-chen, CHAO Xiu-zhen. Analysis on the factors that influence the treatment outcome of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 284-289. doi: 10.16462/j.cnki.zhjbkz.2020.03.008

Citation:

WEI Wu-jia, MA Bin-zhong, WANG Chao-cai, JIANG Ming-xia, LI Er-chen, CHAO Xiu-zhen. Analysis on the factors that influence the treatment outcome of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 284-289. doi: 10.16462/j.cnki.zhjbkz.2020.03.008

Citation:

WEI Wu-jia, MA Bin-zhong, WANG Chao-cai, JIANG Ming-xia, LI Er-chen, CHAO Xiu-zhen. Analysis on the factors that influence the treatment outcome of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 284-289. doi: 10.16462/j.cnki.zhjbkz.2020.03.008

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Analysis on the factors that influence the treatment outcome of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province

doi: 10.16462/j.cnki.zhjbkz.2020.03.008

Institute for Prevention and Control of Infectious Diseases, Qinghai Provincial Center for Disease Control and Prevention, Xining 810007, China

Funds: National Natural Science Foundations of China(81860593); Qinghai provincial thousand talents program for high-level innovative talents(2017-2)

More Information

Corresponding author: MA Bin-zhong, E-mail:qhxnmbz@126.com
Received Date: 2019-07-04
Rev Recd Date: 2019-10-14
Publish Date: 2020-03-10

Abstract

Abstract

Objective To analyze the treatment outcome and related influencing factors of Tibetan nationality new smear-positive pulmonary tuberculosis patients in Qinghai Province, so as to provide evidence for tuberculosis control and treatment among Tibetan population. Methods Statistical analysis was conducted on 5 564 Tibetan nationality new smear-positive pulmonary tuberculosis cases in Qinghai province who were reported in the China Tuberculosis Information Management System and approved to receive treatment from 2008 to 2017. The main influencing factors were detected by unconditional Logistic regression model analysis, dependent variable was successful treatment or not, independent variables were other factors related to the treatment outcome. Results The treatment success rate of Tibetan nationality new smear-positive pulmonary tuberculosis cases was 87.1%(4 848/5 564), and the adverse outcome rate was 12.9%(716/5 564). Unconditional Logistic regression model analysis indicated that non-full-course supervision management, living in agricultural and pastoral area, having severe disease, floating population, and age older than 60 years were risk factors of adverse outcome. The odds ratio(OR) 95% confidence interval(CI) of the above risk factors were 13.044(10.671-15.944), 2.305(1.703-3.119), 2.090(1.346-3.243), 1.967(1.443-2.682), and 1.909(1.410-2.586). Clinical consultation, farmers and herdsmen were protective factors. The OR(95% CI) were 0.451(0.375-0.543), and 0.786(0.627-0.985). Conclusions Treatment success rate of Tibetan nationality new smear-positive pulmonary tuberculosis cases was low. Therefore, the directly observed treatment short-course(DOTS) strategy should be strictly implemented and the full-course supervision management should be strengthened to improve the treatment success rate. More attention should be paid to the elderly, severe, floating, agricultural and pastoral populations among the Tibetan population.
- Tibetan,
- New smear-positive pulmonary tuberculosis patients,
- Treatment outcome,
- Influencing factors

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References(19)

References

[1]	Smith KC, Armitige L, Wanger A. A review of tuberculosis: reflections on the past, present and future of a global epidemic disease[J]. Expert Rev. Anti-infect Ther, 2003, 1(3): 483-491. DOI: 10.1586/14787210.1.3.483.
[2]	陈伟, 夏愔愔, 李涛, 等. 2015年全球及中国结核病疫情形势分析[J].结核病与肺部健康杂志, 2016, 5(1): 32-36. DOI: 10.3969/j.issn.2095-3755.2016.01.010. Chen W, Xia YY, Li T, et al. Analysis for the global and China TB epidemic situation in 2015[J]. J Tuberc Lung Health, 2016, 5(1): 32-36. DOI: 10.3969/j.issn.2095-3755.2016.01.010.
[3]	王蓉, 李永盛, 马永成, 等. 2013-2016年青海省结核病地区分布情况分析[J].医学动物防制, 2017(12): 1307-1308, 1311. DOI: 10.7629/yxdwfz201712025. Wang R, Li YS, Ma YC, et al. Distribution situation of TB region in Qinghai Province from 2013 to 2016[J]. J Med Pest Control, 2017(12): 1307-1308+1311. DOI: 10.7629/yxdwfz201712025.
[4]	王朝才, 刘燕, 晁秀珍, 等. 2006-2015年青海省肺结核流行特征分析[J].现代预防医学, 2017(03): 19-22. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201703004 Wang ZC, Liu Y, Chao XZ, et al. Epidemiological characteristics of pulmonary tuberculosis of Qinghai, 2006-2015[J]. Modern Prevent Med, 2017(03): 19-22. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201703004
[5]	杨智琪, 胡屹, 赵琦, 等.徐州市两县和乌鲁木齐市涂阳肺结核患者疗效及其影响因素分析[J].中国防痨杂志, 2018, 40(1): 98-105. DOI: 10.3969/j.issn.1000-6621.2018.01.022. Yang ZQ, Hu Y, Zhao Q, et al. Treatment outcomes and associated factors among smear-positive pulmonary tuberculosis patients in two counties of Xuzhou, Jiangsu Province and Urumqi, Xinjiang Uygur Autonomous Region[J]. Chin J Antituberc, 2018, 40(1): 98-105. DOI: 10.3969/j.issn.1000-6621.2018.01.022.
[6]	刘凤仁, 叶临湘, 梁享生, 等.影响肺结核治疗转归的因素分析[J].中国防痨杂志, 2006, 28(4): 247-249. DOI: 10.3969/j.issn.1000-6621.2006.04.016. Liu FR, Ye LX, Liang XS, et al. Analysis on factors influencing the treatment outcome of tuberculosis patient[J]. Chin J Antituberc, 2006, 28(4): 247-249. DOI: 10.3969/j.issn.1000-6621.2006.04.016.
[7]	卫生部疾病预防控制局.中国结核病防治规划实施工作指南, 2008年版[M].北京: 中国协和医科大学出版社, 2009. Bureau of disease prevention and control, Ministry of health guidelines for tuberculosis prevention and control planning in China, 2008[M]. BeiJing: China Union Medical University Press, 2009.
[8]	杜雨华, 卢次勇, 陈其琛.广州市涂阳肺结核患者治疗失败及病死的影响因素分析[J].中国防痨杂志, 2007, 29(3): 226-229. DOI: 10.3969/j.issn.1000-6621.2007.03.006. Du YH, Lu CY, Chen QC. Analysis on the factors that influence the treatment failure and death of smear-positive pulmonary tuberculosis patients in Guangzhou city[J]. Chin J Antituberc, 2007, 29(3): 226-229. DOI: 10.3969/j.issn.1000-6621.2007.03.006.
[9]	陆丽红, 刘爱华, 周流凤, 等.北海市实施结核病防治十年规划终期效果评价[J].广西医学, 2012, 34(3): 348-351. DOI: 10.3969/j.issn.0253-4304.2012.03.035. Lu LH, Liu AH, Zhou LF, et al. Final effect evaluation on national tuberculosis control program in Beihai city[J]. Guangxi Med J, 2012, 34(3): 348-351. DOI: 10.3969/j.issn.0253-4304.2012.03.035.
[10]	戈启萍, 孔忠顺, 卜建玲, 等. 95例住院高龄肺结核临床分析[J].中国防痨杂志, 2000, 22(4): 188-191. DOI: 10.3969/j.issn.1000-6621.2000.04.004. Ge QP, Kong ZS, Po JL, et al. Clinical analysis of 95 cases inpatients with pulmonary tuberculosis in the senility[J]. Chin J Antituberc, 2000, 22(4): 188-191. DOI: 10.3969/j.issn.1000-6621.2000.04.004.
[11]	吴妍, 李琦.老年肺结核的诊治现状与进展[J].中国防痨杂志, 2015, 37(9): 975-978. DOI: 10.3969/j.issn.1000-6621.2015.09.012. Wu Y, Li Q. The status and progress of diagnosis and treatment for elderly patients with tuberculosis[J]. Chin J Antituberc, 2015, 37(9): 975-978. DOI: 10.3969/j.issn.1000-6621.2015.09.012.
[12]	杨应周.关注脆弱人群的结核病防控[J].中国防痨杂志, 2013, 35(11): 868-870. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgflzz201311004 Yang YZ. Pay attention to tuberculosis prevention and control in vulnerable population[J]. Chin J Antituberc, 2013, 35(11): 868-870. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgflzz201311004
[13]	张耀亭.肺结核控制的重点难点和亮点[J].东南国防医药, 2005, 7(2): 156-157. DOI: 10.3969/j.issn.1672-271X.2005.02.046. Zhang YT. The stress, difficult and bright point on controlling of pulmonary tuberculosis[J]. Journal of Southeast China National Defence Medical Science, 2005, 7(2): 156-157. DOI: 10.3969/j.issn.1672-271X.2005.02.046.
[14]	徐广保, 刘飞鹰, 冯启明, 等.广西农村肺结核病防治管理新模式的效果评价[J].中华预防医学杂志, 2011, 45(1): 30-35. DOI: 10.3760/cma.j.issn.0253-9624.2011.01.009. Xu GB, Liu FY, Feng QM, et al. The effect evaluation of a new tuberculosis management model in rural areas of Guangxi[J]. Chin J Prev Med, 2011, 45(1): 30-35. DOI: 10.3760/cma.j.issn.0253-9624.2011.01.009.
[15]	沈建恩, 雷涛, 王祖恩, 等.肺结核病人化疗依从性相关因素研究[J].中国防痨杂志, 2007, 29(2): 133-135. DOI: 10.3969/j.issn.1000-6621.2007.02.006. Shen JE, Lei T, Wang ZE, et al. Study on the relevant factors of compliance that affect the regular treatment for pulmonary TB[J]. Chin J Antituberc, 2007, 29(2): 133-135. DOI: 10.3969/j.issn.1000-6621.2007.02.006.
[16]	蔡穆, 黎永华.三亚市流动人口肺结核患者实施全程督导管理效果分析[J].中国全科医学, 2018, 21(z1): 139-140. DOI: 10.3969/j.issn.1007-9572.2018.z1.057. Cai M, Li YH. Analysis on the effect of directly observed treatment of tuberculosis patients about floating population in Sanya city[J]. Chin Gen Pract, 2018, 21(z1): 139-140. DOI: 10.3969/j.issn.1007-9572.2018.z1.057.
[17]	杨世平, 许云飞.直接面视下全程督导管理策略实施效果分析[J].中国防痨杂志, 2003, 25(s1): 199-200. DOI: 10.3969/j.issn.1000-6621.2003.z1.325. Yang SP, Xu YF. Analysis of the implementation effect of directly observed treatment[J]. Chin J Antituberc, 2003, 25(s1): 199-200. DOI: 10.3969/j.issn.1000-6621.2003.z1.325.
[18]	王撷秀.积极发现、治愈肺结核病人[J].中国防痨杂志, 2001, 23(4): 213. DOI: 10.3969/j.issn.1000-6621.2001.04.007. Wang XX. Actively discover and cure tuberculosis patients[J]. Chin J Antituberc, 2001, 23(4): 213. DOI: 10.3969/j.issn.1000-6621.2001.04.007.
[19]	陈瑜.某市2006年-2010年初治涂阳肺结核的化疗效果分析[J].中国医药指南, 2012, (26): 490-491. DOI: 10.15912/j.cnki.gocm.2012.26.257. Chen Y. Analysis of chemotherapy effect of new smear positive pulmonary tuberculosis in a city from 2006 to 2010[J]. Guide of China Medicine, 2012, (26): 490-491. DOI: 10.15912/j.cnki.gocm.2012.26.257.