Analysis of the positive conversion rate of negative spouse and survival analysis on HIV sero-discordant couples

FU Yuan-sheng; ZHANG Qi; LIU Xue-wen; DING Zhi-qiang; WANG Xiu; DAI Se-ying; FAN Yin-guang

doi:10.16462/j.cnki.zhjbkz.2020.03.012

Volume 24 Issue 3

Jun. 2020

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FU Yuan-sheng, ZHANG Qi, LIU Xue-wen, DING Zhi-qiang, WANG Xiu, DAI Se-ying, FAN Yin-guang. Analysis of the positive conversion rate of negative spouse and survival analysis on HIV sero-discordant couples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 308-313. doi: 10.16462/j.cnki.zhjbkz.2020.03.012

Citation:

FU Yuan-sheng, ZHANG Qi, LIU Xue-wen, DING Zhi-qiang, WANG Xiu, DAI Se-ying, FAN Yin-guang. Analysis of the positive conversion rate of negative spouse and survival analysis on HIV sero-discordant couples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 308-313. doi: 10.16462/j.cnki.zhjbkz.2020.03.012

Citation:

FU Yuan-sheng, ZHANG Qi, LIU Xue-wen, DING Zhi-qiang, WANG Xiu, DAI Se-ying, FAN Yin-guang. Analysis of the positive conversion rate of negative spouse and survival analysis on HIV sero-discordant couples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 308-313. doi: 10.16462/j.cnki.zhjbkz.2020.03.012

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Analysis of the positive conversion rate of negative spouse and survival analysis on HIV sero-discordant couples

doi: 10.16462/j.cnki.zhjbkz.2020.03.012

1.
Department of Epidemiology, School of Public Health, Anhui Medical University, Anhui Province Laboratory of Inflammation and Immune Mediated Diseases, Hefei 230032, China
2.
Preventive Medicine, 2018 Grade, Anhui Medical University, Hefei 230032, China
3.
Health Station of Jingjiu District, Fuyang City, Fuyang 236000, China
4.
Science and Technology Department, Anhui Medical University, Hefei 230032, China
5.
AIDS Department of Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China

FU Yuan-sheng and ZHANG Qi contributed equally to this article

Funds: Natural Science Fund of Anhui Province(1608085MH174); Scientific Research of BSKY from Anhui Medical University(xj201526)

More Information

Corresponding author: FAN Yin-guang, E-mail:fanyinguang@163.com
Received Date: 2020-02-19
Rev Recd Date: 2020-03-01
Publish Date: 2020-03-10

Abstract

Abstract

Objective To analyze the positive conversion rate of negative spouse and the survival analysis on HIV sero-discordant couples. Methods Data were collected from the case report database of the integrated AIDS prevention and control data and information system. HIV sero-discordant couples diagnosed between September 1, 1997 and September 1, 2018 were recruited into the cohort. The participants were divided into three groups as untreated subgroup, routine treatment subgroup and early treatment subgroup according to the situation when they started HIV treatment. The positive conversion rate of negative spouse and the survival were compared among the three subgroups. Results 598 HIV sero-discordant couples were recruited and the overall survival time of the three subgroups were 258.92, 4 987.17 and 862.25 person-year. The rate of positive conversion were 6.18/100, 0.48/100 and 0.23/100 person-year. Multivariate Cox regression model showed that the hazard ratio of routine treatment subgroup(HR=0.052, 95% CI:0.037-0.074) and early treatment subgroup(HR=0.011, 95% CI:0.003-0.035)were lower than untreated subgroup. The risk of death of women was lower than that of men(HR=0.667, 95% CI:0.472-0.944); the older the age, the higher the risk of death(HR=1.041, 95% CI:1.026-1.056); and the risk of death of the unemployed is higher than that of farmers(HR=1.571, 95% CI:1.037-2.381). Conclusion Targeted interventions methods and early antiviral therapy should be taken urgently for sero-discordant couples.
- HIV,
- HIV sero-discordant couples,
- Positive conversion,
- Survival analysis

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References(14)

References

[1]	倪永康, 刘早玲. HIV单阳家庭配偶间传播研究进展[J].疾病预防控制通报, 2019, 34(2): 77-82. DOI: 10.13215/j.cnki.jbyfkztb.1905008 Ni YK, Liu ZL. Development of study on transmission of HIV serodiscordant couples[J]. Bull Dis Control Prev, 2019, 34(2):77-82. DOI: 10.13215/j.cnki.jbyfkztb.1905008
[2]	中国疾病预防控制中心性病艾滋病预防控制中心. 2015年12月全国艾滋病性病疫情及主要防治工作进展[J].中国艾滋病性病, 2016, 22(2): 69. DOI: 10.13419/j.cnki.aids.2016.02.01. National Center for AIDS/STD Control and Prevention, China CDC. Update on the AIDS/STD epidemic in China and main response in control and prevention in December, 2015[J]. Chin J AIDS STD, 2016, 22(2): 69. DOI: 10.13419/j.cnki.aids.2016.02.01.
[3]	王丽艳, 秦倩倩, 丁正伟, 等.中国艾滋病全国疫情数据分析[J].中国艾滋病性病, 2017, 23(4): 330-334. DOI: 10.13419/j.cnki.aids.2017.04.16. Wang LY, Qin QQ, Ding ZW, et al. Current situation of AIDS epidemic in China[J]. Chin J AIDS STD, 2017, 23(4): 330-334. DOI: 10.13419/j.cnki.aids.2017.04.16.
[4]	中华人民共和国卫生部, 联合国艾滋病规划署, 世界卫生组织. 2009年中国艾滋病疫情估计工作报告[R].世界卫生组织, 2010. Chinese Ministry of Health, Joint United Nations Programme on HIV/STD, Word Health Organization. Report on the estimation of AIDS epidemic in China in 2009[R]. Word Health Organization, 2010.
[5]	Sloan CE, Champenois K, Choisy P, et al. Newer drugs and earlier treatment: impact on lifetime cost of care for HIV-infected adults[J]. AIDS, 2012, 26(1): 45-56. DOI: 10.1097/QAD.0b013e32834dce6e.
[6]	Goedel A, Müller S, Schwerdtfeger C, et al. Influence of antiretroviral therapy and cardiovascular disease on the immature platelet fraction in patients living with HIV[J]. Platelets. 2019, 13: 1-7. DOI: 10.1080/09537104.2019.1678114.
[7]	Ping LH, Jabara CB, Rodrigo AG, et al. HIV-1 transmission during early antiretroviral therapy: evaluation of two HIV-1 transmission events in the HPTN 052 prevention study[J]. PLoS One, 2013, 8(9): e71557. DOI: 10.1371/journal.pone.0071557.
[8]	Smith K, Powers KA, Kashuba AD, et al. HIV-1 treatment as prevention: the good, the bad, and the challenges[J]. Curr Opin HIV AIDS, 2011, 6(4): 315-325. DOI: 10.1097/COH.0b013e32834788e7.
[9]	孙红敏.安徽省AIDS患者抗病毒治疗服药依从性及焦虑和抑郁状况研究[D].合肥: 安徽医科大学, 2015. Sun HM. Adherence to antiretroviral therapy, anxiety and depression of AIDS patients in Anhui, China[D]. Hefei: Anhui Medical University, 2015.
[10]	Manuela GH, Ferreros I, Julia A, et al. Gender differences in progression to AIDS and death from HIV seroconversion in a cohort of injecting drug users from 1986 to 2001[J]. J Epidemiol Community Health, 2004, 58(11): 944-950. DOI: 10.1136/jech.2003.017475.
[11]	张静, 曾长玉, 陈学玲, 等.新疆伊犁州HIV单阳家庭早期抗病毒治疗防治效果研究[J].中国妇幼保健, 2015, 30(31): 5446-5448. DOI: 10.7620/zgfybj.j.issn.1001-4411.2015.31.54. Zhang J, Zeng CY, Chen XL, et al. Study on the preventive and curative effect of early antiretroviral therapy in singlepositive HIV families in Yili prefecture of Xinjiang[J]. Maternal and Child Health Care of China, 2015, 30(31): 5446-5448. DOI: 10.7620/zgfybj.j.issn.1001-4411.2015.31.54.
[12]	覃大玲, 覃关国, 吴革珍, 等.鹿寨县抗病毒治疗HIV"单阳家庭"阴性配偶抗体阳转情况及影响因素分析[J].临床医学研究与实践, 2016, 1(25): 114, 116. DOI: 10.19347/j.cnki.2096-1413.2016.25.061. Qin DL, Qin GG, Wu GZ, et al. Analysis of sero-conversion condition and influencing factors of HIV sero-negativepartners among serodiscordant couples in Luzhai County[J]. Clinical Research and Practice, 2016, 1(25):114, 116. DOI: 10.19347/j.cnki.2096-1413.2016.25.061
[13]	徐园园, 朱正平, 吴苏姝, 等. 2004-2016年南京市男男性行为者中首次接受抗病毒治疗的HIV/AIDS病人生存分析[J].中国艾滋病性病, 2018, 24(7): 697-701. DOI: 10.13419/j.cnki.aids.2018.07.15. Xu YY, Zhu ZP, Wu SS, et al. Survival analysis of HIV/AIDS patients among MSM initially receiving antiretroviral therapy in Nanjing, 2004-2016[J]. Chin J AIDS STD, 2018, 24(7): 697-701. DOI: 10.13419/j.cnki.aids.2018.07.15.
[14]	姚书杰, 吕娅妮, 王莉, 等.辽宁省2003-2015年7255例艾滋病抗病毒治疗患者的生存分析[J].中华疾病控制杂志, 2016, 20(12): 1203-1207. DOI: 10.16462/j.cnki.zhjbkz.2016.12.005. Yao SJ, Lv YN, Wang L, et al. The survival analysis in 7255 AIDS patients on antiretroviral therapy in Liaoning Province in 2003-2015[J]. Chin J Dis Control Prev, 2016, 20(12): 1203-1207. DOI: 10.16462/j.cnki.zhjbkz.2016.12.005.