Association between circulating vaspin levels and the risk of gestational diabetes mellitus:A systematic review and Meta-analysis

LONG Si-si; MA Shu-juan; ZHANG Jia-yue; GUO Chu-hao; TAN Hong-zhuan

doi:10.16462/j.cnki.zhjbkz.2020.03.020

Volume 24 Issue 3

Jun. 2020

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(3): 354-358

LONG Si-si, MA Shu-juan, ZHANG Jia-yue, GUO Chu-hao, TAN Hong-zhuan. Association between circulating vaspin levels and the risk of gestational diabetes mellitus:A systematic review and Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 354-358. doi: 10.16462/j.cnki.zhjbkz.2020.03.020

Citation:

LONG Si-si, MA Shu-juan, ZHANG Jia-yue, GUO Chu-hao, TAN Hong-zhuan. Association between circulating vaspin levels and the risk of gestational diabetes mellitus:A systematic review and Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 354-358. doi: 10.16462/j.cnki.zhjbkz.2020.03.020

Citation:

LONG Si-si, MA Shu-juan, ZHANG Jia-yue, GUO Chu-hao, TAN Hong-zhuan. Association between circulating vaspin levels and the risk of gestational diabetes mellitus:A systematic review and Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 354-358. doi: 10.16462/j.cnki.zhjbkz.2020.03.020

PDF( 1598 KB)

Association between circulating vaspin levels and the risk of gestational diabetes mellitus:A systematic review and Meta-analysis

doi: 10.16462/j.cnki.zhjbkz.2020.03.020

Xiangya School of Public Health, Central South University, Changsha 410008, China

Funds: National Natural Science Foundation of China(81773535); Key Research and Development Program of Hunan Province(2018SK2061)

More Information

Corresponding author: TAN Hong-zhuan, E-mail:tanhz99@qq.com
Received Date: 2019-10-29
Rev Recd Date: 2020-01-21
Publish Date: 2020-03-10

Abstract

Abstract

Objective To review the existing literature and quantitatively evaluate the association of circulating vaspin levels and the risk of gestational diabetes mellitus(GDM). Methods We systematically searched the PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, and WanfangData databases up to June 2019. Pooled standardized mean differences(SMDs) with 95% confidence intervals(CIs) were calculated using random-or fixed-effects models based on the heterogeneity of studies. Subgroup analyses, Meta-regression, sensitivity and publication bias were assessed to analyze the heterogeneity and the robustness of the results. All statistical analyses were performed using STATA 12.0. Results Nine articles(11 comparisons) published from 2013 to 2019 were included in our final Meta-analysis, covering a total of 738 patients with GDM and 661 normal pregnant women. There was significant difference in the overall maternal circulating vaspin levels between GDM patients and healthy pregnant women(SMD=0.613, 95% CI: 0.044-1.182, P=0.035). Subgroup analyses stratified by trimester in which vaspin was measured and whether BMI was matched suggested the similar trend to the overall result. Subgroup analysis according to ethnicity found that circulating vaspin level might not be related to GDM in "European" subgroup; sensitivity analysis by excluding moderate-quality studies and BMI-unmatched studies found that circulating vaspin levels were still related to GDM risk. Conclusions Our Meta-analysis indicated that maternal circulating vaspin levels might be positively correlated with the risk of GDM in Asians.
- Vaspin level,
- Gestational diabetes mellitus,
- Body mass index,
- Systematic review,
- Meta-analysis

FullText(HTML)

References(23)

References

[1]	American Diabetes A. Gestational diabetes mellitus[J]. Diabetes care, 2004, 27 Suppl 1: S88-90. DOI: 10.2337/diacare.27.2007.s88.
[2]	Zhu Y, Zhang C. Prevalence of Gestational diabetes and risk of progression to type 2 diabetes: a global perspective[J]. CurrDiab Rep, 2016, 16(1): 7. DOI: 10.1007/s11892-015-0699-x.
[3]	Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes[J]. N Engl J Med, 2008, 358(19): 1991-2002. DOI: 10.1056/NEJMoa0707943.
[4]	Bellamy L, Casas JP, Hingorani AD, et al. Type 2 diabetes mellitus after gestational diabetes: a systematic review and Meta-analysis[J]. Lancet, 2009, 373(9677): 1773-1779. DOI: 10.1016/S0140-6736(09)60731-5.
[5]	Li J, Song C, Li C, et al. Increased risk of cardiovascular disease in women with prior gestational diabetes: A systematic review and Meta-analysis[J]. Diabetes ResClin Pract, 2018, 140: 324-338. DOI: 10.1016/j.diabres.2018.03.054.
[6]	Hida K, Wada J, Eguchi J, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity[J]. Proc Natl Acad Sci U S A, 2005, 102(30): 10610-10615. DOI: 10.1073/pnas.0504703102.
[7]	Youn BS, Kloting N, Kratzsch J, et al. Serum vaspin concentrations in human obesity and type 2 diabetes[J]. Diabetes, 2008, 57(2): 372-377. DOI: 10.2337/db07-1045.
[8]	Mierzynsk IR, Poniedzialek-Czajkowska E, Dluski D, et al. Nesfatin-1 and Vaspin as Potential Novel Biomarkers for the Prediction and Early Diagnosis of Gestational Diabetes Mellitus[J]. Int J Mol Sci, 2019, 20(1): E159. DOI: 10.3390/ijms20010159.
[9]	Huo Y, Liu SX, Song GY, et al. Plasma levels and placental expression of vaspin in pregnant women with diabetes mellitus[J]. Braz J Med Bio Res, 2015, 48(3): 273-279. DOI: 10.1590/1414-431X20143432.
[10]	Teshigawara S, Wada J, Hida K, et al. Serum vaspin concentrations are closely related to insulin resistance, and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population[J]. J Clin Endocrinol metab, 2012, 97(7): E1202-1207. DOI: 10.1210/jc.2011-3297.
[11]	Mm WQ, Fan JX, Khor S, et al. Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus[J]. Eur J Obstet Gynecol Reprod Biol, 2014, 182: 98-101. DOI: 10.1016/j.ejogrb.2014.09.008.
[12]	Jia X, Wang S, Ma N, et al. Comparative analysis of vaspin in pregnant women with and without gestational diabetes mellitus and healthy non-pregnant women[J]. Endocrine, 2015, 48(2): 533-540. DOI: 10.1007/s12020-014-0318-7.
[13]	王锐, 陆强, 王术艺, 等.血清25羟维生素D及vaspin水平与妊娠糖尿病关系的研究[J].国际内分泌代谢杂志, 2015, 5(35): 306-308. DOI: 10.3760/cma.j.issn.1673-4157.2015.05.005. Wang R, Lu Q, Wang SY, et al.Relationship between serum 25 hydroxy vitamin D, vaspin and gestafional diabetes mellitu[J]. Int J Endocrinol metab, 2015, 5(35):306-308. DOI: 10.3760/cma.j.issn.1673-4157.2015.05.005
[14]	张天嵩.实用循证医学方法学[M].第2版.长沙: 中南大学出版社, 2011. Zhang TS. Applied methodology for evidence-based medicine.[M]. 2rd ed. Changsha: Central South University Press, 2011.
[15]	Van Dijk GM, Maneva M, ColpaniV, et al. The association between vasomotor symptoms and metabolic health in peri-and postmenopausal women: a systematic review[J]. Maturitas, 2015, 80(2): 140-147. DOI: 10.1016/j.maturitas.2014.11.016.
[16]	Whitehead A, Whitehead J. A general parametric approach to the Meta-analysis of randomized clinical trials[J]. Stat Med, 1991, 10(11): 1665-1677. doi: 10.1002/sim.4780101105
[17]	Melsen WG, Bootsma MC, Rovers MM, et al. The effects of clinical and statistical heterogeneity on the predictive values of results from Meta-analyses[J]. Clin Microbiol Infect, 2014, 20(2): 123-129. DOI: 10.1111/1469-0691.12494.
[18]	袁涛, 王相清, 赵维纲, 等.不同糖耐量状态孕妇血清脂肪因子水平[J].中国临床营养杂志, 2015, 23(4): 203-208. doi: 10.3760/cma.j.issn.1674-635X.2015.04.002 Yuan T, Wang XQ, Zhao WG, et al. Serum adipocytokines in pregnant women with different glucose metabolism status [J]. Chin J Clin Nutr, 2015, 23(4):203-208. DOI: 10.3760/cma.j.issn.1674-635X.2015.04.002.
[19]	龚淼. OGTT对GDM孕妇血清vaspin水平的影响[D].唐山: 华北理工大学, 2018. Gong M. Changes in serum vaspin levels after Oral Glucose Tolerance Test in women withgestational diabetes mellitus[D]. Tangshan: North China University of Science and Technology, 2018.
[20]	Tang Y, Qiao P, Qu X, et al. Comparison of serum vaspin levels and vaspin expression in adipose tissue and smooth muscle tissue in pregnant women with and without gestational diabetes[J]. Clin Endocrinol(Oxf), 2017, 87(4): 344-349. DOI: 10.1111/cen.13403.
[21]	Gkiomisi A, Makedou KG, Anastasilakis AD, et al. Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum[J]. Cytokine, 2013, 61(1): 127-132. DOI: 10.1016/j.cyto.2012.09.006.
[22]	张丽萍.妊娠期糖尿病患者胎盘中炎症介质表达量与母体胰岛素抵抗、脂代谢的相关性研究[J].中国妇幼保健, 2018, 16(33): 3635-3638. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgfybj201816011 Zhang LP. Relationship between inflammatory mediator expression and maternal insulin resistance and lipid metabolism in placenta of patients with gestational diabetes mellitus[J]. Maternal and Child Health Care of China, 2018, 16(33): 3635-3638. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgfybj201816011
[23]	Suleymanoglu S, Tascilar E, Pirgon O, et al. Vaspin and its correlation with insulin sensitivity indices in obese children[J]. Diabetes Res Clin Pract, 2009, 84(3): 325-328. DOI: 10.1016/j.diabres.2009.03.008.