Review on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis

XIE Jia-xin; SHEN Shu-ning

doi:10.16462/j.cnki.zhjbkz.2020.03.021

Volume 24 Issue 3

Jun. 2020

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XIE Jia-xin, SHEN Shu-ning. Review on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 359-364. doi: 10.16462/j.cnki.zhjbkz.2020.03.021

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XIE Jia-xin, SHEN Shu-ning. Review on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 359-364. doi: 10.16462/j.cnki.zhjbkz.2020.03.021

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Review on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis

doi: 10.16462/j.cnki.zhjbkz.2020.03.021

XIE Jia-xin^{1
,
,},
SHEN Shu-ning²

1.
Department of High Altitude Operation Medicine, College of High Altitude Military Medicine, Army Medical University, Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Key Laboratory of High Altitude Medicine, PLA, Chongqing 400038, China
2.
The 984th Hospital of PLA, Beijing 100094, China

Funds: National Natural Science Foundation of China(81803294); Natural Science Foundation of Hebei Province(H2015509001)

More Information

Corresponding author: XIE Jia-xin, E-mail:xiejiaxin1006@163.com
Received Date: 2019-07-10
Rev Recd Date: 2019-09-17
Publish Date: 2020-03-10

Abstract

Abstract

Abnormal expression of androgen receptor(AR) and AR-mediated signaling pathways are closely related to the occurrence, outcome, and prognosis of various human disease, and to some extent, AR lead to gender differences in these diseases. However, the specific mechanism is still unclear. CAG short tandem repeat(STR) sequence in exon 1 of AR gene negatively correlates with the transcriptional regulation activity, affects the synthesis and biological function of the target proteins, and plays an important role in the development and prognosis of various tumors, such as prostate cancer, breast cancer, bladder cancer, liver cancer, and endometrial cancer. In this review, we summarized the current studies on the association between AR gene CAG STR and the common tumors, in order to provide clues for further exploring the mechanism of AR-related tumors with high incidence and gender differences, and screening populations with high risk for the corresponding tumors.
- Androgen receptor,
- Tumor,
- Short tandem repeat,
- Polymorphism

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References(35)

References

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