Association between total cholesterol and type 2 diabetes:a prospective cohort study

LU Yuan; LIU Huan-le; MA Yun-tao; DAI Xiao-yu; WANG Zhi-heng; LIU Yan-xun

doi:10.16462/j.cnki.zhjbkz.2020.04.002

Volume 24 Issue 4

Jun. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(4): 380-383

LU Yuan, LIU Huan-le, MA Yun-tao, DAI Xiao-yu, WANG Zhi-heng, LIU Yan-xun. Association between total cholesterol and type 2 diabetes:a prospective cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 380-383. doi: 10.16462/j.cnki.zhjbkz.2020.04.002

Citation:

LU Yuan, LIU Huan-le, MA Yun-tao, DAI Xiao-yu, WANG Zhi-heng, LIU Yan-xun. Association between total cholesterol and type 2 diabetes:a prospective cohort study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 380-383. doi: 10.16462/j.cnki.zhjbkz.2020.04.002

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Association between total cholesterol and type 2 diabetes:a prospective cohort study

doi: 10.16462/j.cnki.zhjbkz.2020.04.002

LU Yuan^{1, 2},
LIU Huan-le³,
MA Yun-tao⁴,
DAI Xiao-yu^{1, 2},
WANG Zhi-heng^{1, 2},
LIU Yan-xun^{1, 2
,
,}

1.
Department of Biostatistics, School of Public Health, Cheeloo College of Medcine, Shandong University, Jinan 250012, China
2.
Healthcare Big Data Institute of Shandong University, Jinan 250012, China
3.
Department of Health Care, Shengli Oilfield Central Hospital, Dongying 257000, China
4.
The Second Hospital Lanzhou University, Lanzhou 730030, China

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Corresponding author: LIU Yan-xun, E-mail:liu-yx@sdu.edu.cn
Received Date: 2019-06-10
Rev Recd Date: 2019-09-17
Publish Date: 2020-04-10

Abstract

Abstract

Objective To explore the association between total cholesterol and type 2 diabetes(T2 DM). Methods Non-diabetic people who aged 20 to 90 years at the baseline and who had physical examination more than 2 times were screened. Comparisons of the baseline characteristics were conducted with Student-t test or Pearson chi-square test. Generalized estimating equation(GEE) was used to analyze the effect of total cholesterol of quantiles groups(2.10-mmol/L, 4.16-mmol/L, 4.76-mmol/L and 5.42-13.29 mmol/L) to type 2 diabetes. Results The cohort with an average age of 3.53 years per person included 12 928 subjects and 45 626 person-years. During the follow-up, 447 cases of new-onset diabetes occurred and the incidence density was 9.80‰. The high incidence of type 2 diabetes increased with the increase of total cholesterol. After adjusting the factors including age, high density lipoprotein, hypertension and obesity, based on the 2.10-mmol/L group, the relative risk(RR) of the 4.16-mmol/L, 4.76-mmol/L and 5.42-13.29 mmol/L group were 1.24(95% CI:0.83-1.86), 1.75(95% CI:1.19-2.56)and 3.60(95% CI:2.51-5.17), respectively. Conclusions Total cholesterol is associated with type 2 diabetes, and as the total cholesterol increases, the risk of developing type 2 diabetes increases.
- Type 2 diabetes,
- Total cholesterol,
- Longitudinal data,
- Generalized estimating equation

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References(23)

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