Correlation between CTRP3 and serum uric acid levels in patients with newly diagnosed type 2 diabetes

XU Jin-xiu; ZHANG Jun-xia; XIANG Guang-da; ZHANG Bi-lin; LIN Xue

doi:10.16462/j.cnki.zhjbkz.2020.04.005

Volume 24 Issue 4

Jun. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(4): 394-398

XU Jin-xiu, ZHANG Jun-xia, XIANG Guang-da, ZHANG Bi-lin, LIN Xue. Correlation between CTRP3 and serum uric acid levels in patients with newly diagnosed type 2 diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 394-398. doi: 10.16462/j.cnki.zhjbkz.2020.04.005

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XU Jin-xiu, ZHANG Jun-xia, XIANG Guang-da, ZHANG Bi-lin, LIN Xue. Correlation between CTRP3 and serum uric acid levels in patients with newly diagnosed type 2 diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 394-398. doi: 10.16462/j.cnki.zhjbkz.2020.04.005

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Correlation between CTRP3 and serum uric acid levels in patients with newly diagnosed type 2 diabetes

doi: 10.16462/j.cnki.zhjbkz.2020.04.005

1.
School of Medicine, Wuhan University of Science and Technology, Hubei 430065, China
2.
Department of Endocrinology, Central Theater Command General Hospital of the Chinese People's Liberation Army, Hubei 430070, China

Funds: The National Natural Science Foundation of China(81500654); Hubei Province Health and Family Planning Scientific Research Project(WJ2018H0062); The Bethune-Merck Diabetes Research Foundation(G2018030)

More Information

Corresponding author: ZHANG Jun-xia, E-mail:zhangjx023@163.com
Received Date: 2019-09-18
Rev Recd Date: 2020-01-08
Publish Date: 2020-04-10

Abstract

Abstract

Objective To investigate the correlation between serum complement C1 q/tumor necrosis factor-related protein-3(CTRP3) and serum uric acid levels in patients with newly diagnosed type 2 diabetes mellitus(T2 DM). Methods A total of 152 patients with newly diagnosed T2 DM from Central Theater Command General Hospital were enrolled. Based on the visceral fat area(VFA), the subjects were divided into non-abdominal obesity group [AO(-) group](n=79) and abdominal obesity group [AO(+) group](n=73). Spearman correlation analysis was used to analyze the correlation between serum CTRP3 and uric acid as well as other parameters.Multiple stepwise regression analysis model was used to analyze the independent effect of CTRP3 on serum uric acid levels in patients with newly diagnosed T2 DM. Results When compared with AO(-) group, patients in AO(+) group had higher levels of serum uric acid(P=0.029) and lower CTRP3(P < 0.001). Spearman correlation analysis showed that CTRP3 was negatively correlated with serum uric acid in the whole subjects and AO(+) group(r=-0.180, r=-0.518, all P < 0.05). However, there was no correlation between CTRP3 and uric acid as well as other parameters in AO(-) group(allP > 0.05). Multiple stepwise regression analysis demonstrated that CTRP3 was an independent contributor to serum uric acid levels in AO(+) group(β=-0.290, P=0.005), while not in AO(-) group. Conclusions Serum CTRP3 was an independent influencing factor and negatively correlated with serum uric acid levels in patients with newly diagnosed T2 DM, in an obesity-dependent manner.
- Complement C1q/tumor necrosis factor-related protein-3,
- Serum uric acid,
- Type 2 diabetes mellitus,
- Abdominal obesity,
- Insulin resistance

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References(19)

References

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