Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion

XIE Li-ao; YAO Jian-ling; ZHU Tian-yuan; AI Shi-wei; DANG Yu-hui; LI Zhi-lan

doi:10.16462/j.cnki.zhjbkz.2020.04.023

Volume 24 Issue 4

Jun. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(4): 489-492

XIE Li-ao, YAO Jian-ling, ZHU Tian-yuan, AI Shi-wei, DANG Yu-hui, LI Zhi-lan. Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 489-492. doi: 10.16462/j.cnki.zhjbkz.2020.04.023

Citation:

XIE Li-ao, YAO Jian-ling, ZHU Tian-yuan, AI Shi-wei, DANG Yu-hui, LI Zhi-lan. Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 489-492. doi: 10.16462/j.cnki.zhjbkz.2020.04.023

Citation:

XIE Li-ao, YAO Jian-ling, ZHU Tian-yuan, AI Shi-wei, DANG Yu-hui, LI Zhi-lan. Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(4): 489-492. doi: 10.16462/j.cnki.zhjbkz.2020.04.023

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Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion

doi: 10.16462/j.cnki.zhjbkz.2020.04.023

1.
School of Public Health, Lanzhou University, Lanzhou 730030, China
2.
Jingning County Maternal and Child Care Hospital, Jingning 743400, China
3.
Cavity mirror Center, Lanzhou Maternity and Child Care Hospital, Lanzhou 730030, China

Funds: Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-38)

More Information

Corresponding author: LI Zhi-lan, E-mail:lizhl@lzu.edu.cn
Received Date: 2019-11-14
Rev Recd Date: 2020-01-18
Publish Date: 2020-04-10

Abstract

Abstract

Objective To investigate the effects of levels of mercury, manganese, nickel, copper, zinc, arsenic, cadmium, and lead in serum during early pregnancy on missed abortion, and to provide clues for the study of the cause of missed abortion. Methods Twenty-one pairs of aborted patients of the same age, with the same gestational age, and normal early pregnancy were selected, and the levels of serum mercury, manganese, nickel, copper, zinc, arsenic, cadmium, and lead in the two groups of pregnant women were detected. Multivariate Logistic regression was used to analyze the possible influencing factors of missed abortion. Results Compared with the normal early pregnancy group, the serum levels of nickel(t=3.57, P=0.002), copper(t=7.94, P < 0.001), zinc(t=3.60, P=0.002), cadmium(t=4.74, P < 0.001), arsenic(t=2.82, P=0.011), and lead(t=3.46, P=0.002) were higher in the missed abortion group, and the serum manganese levels were lower(t=-8.24, P < 0.001). The binary multivariate logistic regression showed that theOR values of high blood nickel and high blood cadmium were 7.83(95% CI: 1.03-59.68, P =0.037), 3.51(95% CI:2.53-4.87, P =0.004) and 0.68(95% CI:0.47-0.97, P =0.034). Conclusion The levels of Ni, Cd and Mn in pregnant women's serum have a certain effect on the occurrence of missed abortion, and its mechanism needs further study.
- Missed abortion,
- Serum,
- Trace elements,
- Risk factor,
- Protective factor

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References(12)

References

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