Study on the epidemiological characteristics of a large HIV-1 molecular cluster in a low epidemic county

ZENG Ya-li; MI Jia-jun; Lyu Dan; ZHUOMA La-cuo; YAN Tu; LI Ju-mei; ZHU Jun; KANG Fa-yang; LAI Wen-hong; HOU Xue-qin; LIANG Shu; SU Ling

doi:10.16462/j.cnki.zhjbkz.2020.09.021

Volume 24 Issue 9

Sep. 2020

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(9): 1096-1100

ZENG Ya-li, MI Jia-jun, Lyu Dan, ZHUOMA La-cuo, YAN Tu, LI Ju-mei, ZHU Jun, KANG Fa-yang, LAI Wen-hong, HOU Xue-qin, LIANG Shu, SU Ling. Study on the epidemiological characteristics of a large HIV-1 molecular cluster in a low epidemic county[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1096-1100. doi: 10.16462/j.cnki.zhjbkz.2020.09.021

Citation:

ZENG Ya-li, MI Jia-jun, Lyu Dan, ZHUOMA La-cuo, YAN Tu, LI Ju-mei, ZHU Jun, KANG Fa-yang, LAI Wen-hong, HOU Xue-qin, LIANG Shu, SU Ling. Study on the epidemiological characteristics of a large HIV-1 molecular cluster in a low epidemic county[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1096-1100. doi: 10.16462/j.cnki.zhjbkz.2020.09.021

Citation:

ZENG Ya-li, MI Jia-jun, Lyu Dan, ZHUOMA La-cuo, YAN Tu, LI Ju-mei, ZHU Jun, KANG Fa-yang, LAI Wen-hong, HOU Xue-qin, LIANG Shu, SU Ling. Study on the epidemiological characteristics of a large HIV-1 molecular cluster in a low epidemic county[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(9): 1096-1100. doi: 10.16462/j.cnki.zhjbkz.2020.09.021

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Study on the epidemiological characteristics of a large HIV-1 molecular cluster in a low epidemic county

doi: 10.16462/j.cnki.zhjbkz.2020.09.021

1.
Center for Disease Control and Prevention in Sichuan, Chengdu 610041, China
2.
Center for Disease Control and Prevention in Wangcang, Wangcang 628200, China
3.
Center for Disease Control and Prevention in Guangyuan, Guangyuan 628000, China

Funds:

Sichuan Science and Technology Program 2017JY0302

More Information

Corresponding author: SU Ling, E-mail: sl7512@163.com
Received Date: 2019-11-18
Rev Recd Date: 2020-03-03
Publish Date: 2020-09-10

Abstract

Abstract

Objective To study the characteristics of HIV-1 molecular clusters in a low-epidemic county in Sichuan Province, so as to provide a basis for precise intervention. Methods Research subjects included HIV/AIDS patients who were newly diagnosed from January 2011 to March 2019 in a low-epidemic county in Sichuan Province, of whom the HIV-1 pol gene was sequenced, and molecular cluster analysis was performed. Epidemiological questionnaire survey was conducted among survival cases. Results Among 113 newly diagnosed cases, 49.6% (56/113) belonged to the same molecular cluster (CRF01_AE4), and the average genetic distance of this cluster was 0.006 1. The first case was found in 2011 and there was a trend of continuous rapid growth (χ²_trend=11.626, P=0.001). The cases in the cluster were mainly seniors (average age was 50.5±13.0), low-educated (42.9%), married (67.9%), male (76.8%) and only few had a going-out history (17.0%). 45.5% were infected through heterosexual commercial sexual behaviors, and the sexual transactions mainly occurred in low-cost commercial sex venues (55.0%) in local areas (87.5%), and never consistently used condoms in the sex trade. 75.0% cases who were infected through heterosexual commercial sex were mainly diagnosed since 2016. One case, who continued having high-risk sexual behaviors after being informed and refused the anti-retroviral therapy, was found connecting with multiple cases in the molecular transmission cluster. Conclusions A large-scale transmission network had continued to expand rapidly in a HIV low-endemic county and sexual transactions in local low-cost commercial sex venues were the main reason for the network expansion.
- HIV-1,
- Molecular cluster,
- Epidemiological characteristics

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References(14)

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