The immune response to hepatitis B vaccine and its influencing factors of infants born to HBsAg positive mothers

HU Ni; LI Fang; XU Jing-ning; ZHANG Ying; YAN Min; LIU Cun; ZHANG Lei

doi:10.16462/j.cnki.zhjbkz.2020.11.003

Volume 24 Issue 11

Dec. 2020

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HU Ni, LI Fang, XU Jing-ning, ZHANG Ying, YAN Min, LIU Cun, ZHANG Lei. The immune response to hepatitis B vaccine and its influencing factors of infants born to HBsAg positive mothers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1252-1256. doi: 10.16462/j.cnki.zhjbkz.2020.11.003

Citation:

HU Ni, LI Fang, XU Jing-ning, ZHANG Ying, YAN Min, LIU Cun, ZHANG Lei. The immune response to hepatitis B vaccine and its influencing factors of infants born to HBsAg positive mothers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1252-1256. doi: 10.16462/j.cnki.zhjbkz.2020.11.003

Citation:

HU Ni, LI Fang, XU Jing-ning, ZHANG Ying, YAN Min, LIU Cun, ZHANG Lei. The immune response to hepatitis B vaccine and its influencing factors of infants born to HBsAg positive mothers[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1252-1256. doi: 10.16462/j.cnki.zhjbkz.2020.11.003

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The immune response to hepatitis B vaccine and its influencing factors of infants born to HBsAg positive mothers

doi: 10.16462/j.cnki.zhjbkz.2020.11.003

HU Ni^{1, 2},
LI Fang³,
XU Jing-ning⁴,
ZHANG Ying³,
YAN Min¹,
LIU Cun²,
ZHANG Lei^{1
,
,}

1.
Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Military Preventive Medicine, Air Force Military Medical University, Xi'an 710032, China
2.
Science, Education and Information Section, Center for Disease Control and Prevention Xi'an 710054, China
3.
Women's Health Division, China Northwest Women and Children Hospital, Xi'an 710061, China
4.
Obstetrics, China Northwest Women and Children Hospital, Xi'an 710061, China

Funds:

National Natural Science Foundation of China 81102140

National Natural Science Foundation of China 81472988

More Information

Corresponding author: ZHANG Lei, E-mail:drzhanglei@fmmu.edu.cn
Received Date: 2020-05-21
Rev Recd Date: 2020-07-14
Publish Date: 2020-11-10

Abstract

Abstract

Objective To obtain the probability of no/weak immune response to the hepatitis B vaccine of infants born to HBsAg-positive parturients, so as to analyze its influencing factors. Methods A study of 284 pairs of HBsAg-positive pregnant women and their infants who gave birth at the Northwest Women and Childre's Hospital of Shaanxi Province from January 2016 to April 2017 was carried out to follow up of infant hepatitis B vaccination and the production of serological markers. Results The rate of immune deficiency and weak response in high-risk children was 10.57%. The rate of immune deficiency and weak response in pregnant women with "HBsAg+, HBeAg+, HBcAb+" infection pattern was 19.64%, which was significantly higher than that of pregnant women in "HBsAg+, HBeAb+, HBcAb+" mode, which was 9.89% (RR=1.99, 95% CI: 1.01-3.92, P < 0.001). The risk of HBsAg-positive mothers with puncture history during pregnancy was 6.72 times higher than that of children with no puncture history (RR=6.72, 95% CI: 2.79-16.19, P=0.049). The liver function albumin (ALB) of the mothers who had immune deficiency and weak response to hepatitis B vaccine in young children was significantly lower than that in the strong response group (t=2.518, P=0.013). The liver function-to-white ratio (A/G) of the mothers who had immune deficiency and weak response to hepatitis B vaccine was significantly higher than that of the strong response group (t=-5.559, P < 0.001). Conclusions Children born to HBsAg positive mothers are at high risk of immune deficiency and weak response to Hepatitis B vaccine and intrauterine transmission of hepatitis B. Therefore, we should focus on monitoring the HBsAb production of these people. Invasive testing during pregnancy may increase the risk of immune deficiency and weak response to Hepatitis B vaccine in young children. Children have a higher hepatitis B vaccine deficiency and weak response rate when their mother's serological testing remains "HBsAg+, HBeAb+, HBcAb+" mode.
- HBV,
- Hepatitis B vaccine,
- Vaccine response

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References(14)

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