Study on association between lipid levels and HCV infection in remunerated blood donation

WANG Yan; HUANG Peng; YE Xiang-yu; NI Ze-yang; WANG Qiu-wei; HOU Yu-qing; YU Rong-bin

doi:10.16462/j.cnki.zhjbkz.2020.11.004

Volume 24 Issue 11

Dec. 2020

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WANG Yan, HUANG Peng, YE Xiang-yu, NI Ze-yang, WANG Qiu-wei, HOU Yu-qing, YU Rong-bin. Study on association between lipid levels and HCV infection in remunerated blood donation[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1257-1262. doi: 10.16462/j.cnki.zhjbkz.2020.11.004

Citation:

WANG Yan, HUANG Peng, YE Xiang-yu, NI Ze-yang, WANG Qiu-wei, HOU Yu-qing, YU Rong-bin. Study on association between lipid levels and HCV infection in remunerated blood donation[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1257-1262. doi: 10.16462/j.cnki.zhjbkz.2020.11.004

Citation:

WANG Yan, HUANG Peng, YE Xiang-yu, NI Ze-yang, WANG Qiu-wei, HOU Yu-qing, YU Rong-bin. Study on association between lipid levels and HCV infection in remunerated blood donation[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(11): 1257-1262. doi: 10.16462/j.cnki.zhjbkz.2020.11.004

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Study on association between lipid levels and HCV infection in remunerated blood donation

doi: 10.16462/j.cnki.zhjbkz.2020.11.004

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

National Natural Science Foundation of China 81703273

Natural Science Foundation of Jiangsu Province BK20171054

More Information

Corresponding author: YU Rong-bin, E-mail:rongbinyu@njmu.edu.cn
Received Date: 2020-06-10
Rev Recd Date: 2020-08-12
Publish Date: 2020-11-10

Abstract

Abstract

Objective To explore the correlation between hepatitis C virus (HCV) infection and lipid, and determine the influencing factors of dyslipidemia in remunerated blood donation. Methods From March to May 2015, a cross-sectional study was conducted among people over 50 years old in Jiangsu Province. We obtained demographic data and related measurements through questionnaire surveys and blood test. We compared the lipid levels of different HCV infection groups. The influencing factors of dyslipidemia were explored by univariate and multivariate Logistic regression analysis. Results Of a total of 1 537 participants were included, of which 1 234 (80.3%) were uninfected HCV, 117 (7.6%) were HCV spontaneous clearance, and 186 (12.1%) were HCV persistent infection clients. Differences in serum TG and TC levels among the three groups after PSM were statistically significan (all P < 0.05), and those were lower in the participants with persistent infection than the other groups. Dyslipidemia occurred in 286 participants and the prevalence was 18.6%. Multivariate Logistic regression analysis showed that sex (OR=1.41, 95%CI: 1.06-1.87, P=0.018), higher fasting plasma glucose (OR=2.54, 95% CI: 1.75-3.68, P < 0.001) and HCV persistent infection (OR=0.22, 95% CI: 0.12-0.41, P < 0.001) were independent influencing factors for dyslipidemia. Conclusions The serum levels of TG and TC are lower in patients with persistent infection than those uninfected or with spontaneous clearance in remunerated blood donation. HCV infection, sex and fasting plasma glucose are related with dyslipidemia.
- Hepatitis C virus,
- Total cholesterol,
- Triglyceride,
- Influencing factors,
- Remunerated blood donation

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References(23)

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