Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis

HE Pei; WANG Man-li; CAO Rong-rong; DONG Chen-yue; DENG Fei-yan; LEI Shu-feng

doi:10.16462/j.cnki.zhjbkz.2021.08.002

Volume 25 Issue 8

Aug. 2021

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HE Pei, WANG Man-li, CAO Rong-rong, DONG Chen-yue, DENG Fei-yan, LEI Shu-feng. Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 874-878,986. doi: 10.16462/j.cnki.zhjbkz.2021.08.002

Citation:

HE Pei, WANG Man-li, CAO Rong-rong, DONG Chen-yue, DENG Fei-yan, LEI Shu-feng. Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 874-878,986. doi: 10.16462/j.cnki.zhjbkz.2021.08.002

Citation:

HE Pei, WANG Man-li, CAO Rong-rong, DONG Chen-yue, DENG Fei-yan, LEI Shu-feng. Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 874-878,986. doi: 10.16462/j.cnki.zhjbkz.2021.08.002

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Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis

doi: 10.16462/j.cnki.zhjbkz.2021.08.002

1.
Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China
2.
Department of Nephrology, Jiujiang No.1 People's Hospital, Jiujiang 332000, China

Funds:

National Natural Science Foundation of China 81473046

More Information

Corresponding author: LEI Shu-feng, E-mail: leisf@suda.edu.cn
Received Date: 2021-06-29
Rev Recd Date: 2021-07-16

Available Online: 2021-08-24

Publish Date: 2021-08-10

Abstract

Abstract

Objective This study aims to detect the association between gut microbiota and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS). Methods The microbiota-related gene set enrichment analysis (GSEA) was applied to identify rheumatoid diseases-related gut microbiota using published genome-wide association study (GWAS) and GWAS of gut microbiota summary statistic data. Results Several associations between three rheumatoid diseases and gut microbiota were identified (all P < 0.05). Thereinto, Ruminococcaceae_UCG-009 was significantly associated with RA, SLE and AS (all P < 0.05). For RA and SLE, association signals were observed for Intestinibacter and Candidatus_Soleaferrea (all P < 0.05). Conclusion This study found that part of the gut microbiota could be novel regulators of rheumatoid diseases via the effects of its metabolites, and may provide novel clues for revealing the roles of gut microbiota in rheumatology.
- Rheumatoid diseases,
- Gut microbiota,
- GWAS,
- Microbiota-related GSEA

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References(29)

References

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