Study on the association between pulse pressure and renal function decline among middle-aged and elderly people

YANG Xue-ying; TIAN Jing; DAI Qiao-yun; WANG Yong-hong; ZHANG Jun-hui; JIAO Kai-lei; MA Xu; ZHAO Jun

doi:10.16462/j.cnki.zhjbkz.2021.08.015

Volume 25 Issue 8

Aug. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(8): 955-961

YANG Xue-ying, TIAN Jing, DAI Qiao-yun, WANG Yong-hong, ZHANG Jun-hui, JIAO Kai-lei, MA Xu, ZHAO Jun. Study on the association between pulse pressure and renal function decline among middle-aged and elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 955-961. doi: 10.16462/j.cnki.zhjbkz.2021.08.015

Citation:

YANG Xue-ying, TIAN Jing, DAI Qiao-yun, WANG Yong-hong, ZHANG Jun-hui, JIAO Kai-lei, MA Xu, ZHAO Jun. Study on the association between pulse pressure and renal function decline among middle-aged and elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 955-961. doi: 10.16462/j.cnki.zhjbkz.2021.08.015

Citation:

YANG Xue-ying, TIAN Jing, DAI Qiao-yun, WANG Yong-hong, ZHANG Jun-hui, JIAO Kai-lei, MA Xu, ZHAO Jun. Study on the association between pulse pressure and renal function decline among middle-aged and elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 955-961. doi: 10.16462/j.cnki.zhjbkz.2021.08.015

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Study on the association between pulse pressure and renal function decline among middle-aged and elderly people

doi: 10.16462/j.cnki.zhjbkz.2021.08.015

1.
Human Genetic Resources Center, National Research Institute for Family Planning, Beijing 100081, China
2.
Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400013, China

YANG Xue-ying and TIAN Jing contributed equally to this article

Funds:

National Key Research and Development Program 2016YFC1000307

Project of National Research Institute for Family Planning 2018NRIFPJ03

National Population and Reproductive Health Science Data Center 2005DKA32408

More Information

Corresponding author: ZHAO Jun, E-mail: zj@e-health.org.cn
Received Date: 2020-12-30
Rev Recd Date: 2021-04-02

Available Online: 2021-08-24

Publish Date: 2021-08-10

Abstract

Abstract

Objective To explore the association between pulse pressure (PP) and renal function decline among middle-aged and elderly people. Methods A total of 46 605 middle-aged and elderly people (aged ≥45 years old) who participated in the physical examination in the First Affiliated Hospital of Chongqing Medical University from January 1, 2015 to December 31, 2019 were selected as the study objects. According to their PP levels, they were divided into four groups (PP < 40 mm Hg, 40- < 50 mm Hg, 50- < 60 mm Hg, and ≥60 mm Hg). Unconditional Logistic regression model was used to analyze the association between PP and renal function decline. Results The age of the 46 605 people included in this study was 54(48, 60) years old, and 27.37% of them had renal function decline (26.45% were mild, and 0.92% were moderate-severe). Compared with the same age group, the risk of renal function decline increased by 11% and 28% in PP < 40 mm Hg and PP≥60 mm Hg groups among middle-aged and elderly people, respectively. The results of age stratification analysis showed that among middle-aged people aged 45- < 60 years old, the risk of renal function decline increased by 13% (OR=1.13, 95% CI: 1.05-1.22) only in the PP < 40 mm Hg group, while among elderly people aged ≥60 years old, the risk increased by 12% (OR=1.12, 95% CI: 1.02-1.24) and 66% (OR=1.66, 95% CI: 1.48-1.86) in the PP=50- < 60 mm Hg and PP≥60 mm Hg groups, respectively. Restrictive cubic spline results suggested that the association between PP and renal function decline was non-linear, and the risk of renal function decline increased when PP < 42 mm Hg in middle-aged people and PP>55 mm Hg in elderly people. The results of correlation analysis between PP and different degrees of renal function decline showed that the risk of mild renal function decline was increased by 13% (OR=1.13, 95% CI: 1.05-1.22) only in middle-aged people with PP < 40 mm Hg group, while the risk of mild renal function decline was increased by 11%(OR=1.11, 95% CI: 1.01-1.23) in elderly people with PP=50- < 60 mm Hg group, and the risk of mild and moderate-severe renal function decline was increased by 61%(OR=1.61, 95% CI: 1.43-1.81)and 179%(OR=2.79, 95% CI: 1.94-4.02) in elderly people with PP≥60 mm Hg group, respectively. Conclusions The effect of PP on the risk of renal function decline and its degrees was not the same in middle-aged people and elderly people. Special attention should be paid to the renal function of middle-aged people with decreased PP and elderly people with increased PP.
- Middle-aged and elderly people,
- Pulse pressure,
- Renal function decline,
- Estimated glomerular filtration rate

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References(23)

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