Relationship between medium-chain saturated fatty acids and risk of oral cancer

SU Jue; LI Yan-ni; FAN Yi; WANG Si-jie; XU Ming-ming; ZHOU Nan; HE Qi-xuan; YU Dao-xuan; LYU Ji-rong; CHEN Qing; WANG Jing; SHI Bin; QIU Yu; LIN Li-song; ZHENG Xiao-yan; PAN Li-zhen; CHEN Fa; WANG Jing; HE Bao-chang; LIU Feng-qiong

doi:10.16462/j.cnki.zhjbkz.2021.08.018

Volume 25 Issue 8

Aug. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(8): 975-980

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

Citation:

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

Citation:

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

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Relationship between medium-chain saturated fatty acids and risk of oral cancer

doi: 10.16462/j.cnki.zhjbkz.2021.08.018

1.
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China
2.
The Center of Experiment, School of Public Health, Fujian Medical University, Fuzhou 350108, China
3.
Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China

Funds:

Innovative Research Program for Undergraduate of Public Health School of Fujian Medical University 202004

National Natural Science Foundation of China 81503171

More Information

Corresponding author: LIU Feng-qiong, E-mail: lfq@fjmu.edu.cn
Received Date: 2020-08-20
Rev Recd Date: 2020-11-18

Available Online: 2021-08-24

Publish Date: 2021-08-10

Abstract

Abstract

Objective To investigate the association between dietary medium-chain saturated fatty acids and the risk of oral cancer. Methods A case-control study was conducted in 225 patients with diagnosed oral cancer and 527 controls. All participants were recruited from the First Affiliated Hospital of Fujian Medical University from November 14, 2013 to March 21, 2019. The median daily intake of all kinds of fatty acids after energy correction in the control group was divided into groups. Unconditional Logistic regression analysis stratified analysis and multiplicative interaction analysis were performed, stratified analysis and multiplicative interaction analysis were performed to investigate the relationship between medium chain saturated fatty acids and the risk of oral cancer. Results Compared with the low-level group, the total medium-chain saturated fatty acids, octanoic acid, decanoic acid, undecanoic acid and lauric acid in the high-level group may increase the risk of oral cancer. The adjusted OR and 95% CI were 3.19 (95% CI: 2.17-4.69), 2.54 (95% CI: 1.75-3.69)、2.56 (95% CI: 1.76-3.71)、5.00 (95% CI: 3.27-7.64) and 3.09 (95% CI: 2.10-4.54), respectively. Stratified analysis showed that octanoic acid and decanoic acid were risk factors of oral cancer among non-smokers, and they may also increased the risk of oral cancer regardless of drinking status. There was a positive correlation between the daily intake of total medium-chain saturated fatty acids, undecanoic acid and lauric acid and the risk for oral cancer regardless of smoking and drinking status. In addition, there were multiplicative interactions between medium-chain saturated fatty acids and smoking or drinking status. Conclusion A higher level of dietary medium-chain saturated fatty acids may increase the risk of oral cancer.
- Oral cancer,
- Dietary medium chain saturated fatty acid,
- Risk factor,
- Smoking,
- Drinking

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References(24)

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