Interaction effect of hypertension family history and dyslipidemia on the prevalence of hypertension

DU Jin-ling; ZHOU Nan; SONG Ying-qian; WANG Wei-wei; HONG Xin

doi:10.16462/j.cnki.zhjbkz.2022.06.006

Volume 26 Issue 6

Jun. 2022

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DU Jin-ling, ZHOU Nan, SONG Ying-qian, WANG Wei-wei, HONG Xin. Interaction effect of hypertension family history and dyslipidemia on the prevalence of hypertension[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(6): 651-656. doi: 10.16462/j.cnki.zhjbkz.2022.06.006

Citation:

DU Jin-ling, ZHOU Nan, SONG Ying-qian, WANG Wei-wei, HONG Xin. Interaction effect of hypertension family history and dyslipidemia on the prevalence of hypertension[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(6): 651-656. doi: 10.16462/j.cnki.zhjbkz.2022.06.006

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Interaction effect of hypertension family history and dyslipidemia on the prevalence of hypertension

doi: 10.16462/j.cnki.zhjbkz.2022.06.006

DU Jin-ling¹,
ZHOU Nan^{1, 2},
SONG Ying-qian¹,
WANG Wei-wei²,
HONG Xin^{1, 2
,
,}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
Department of Chronic and Non-communicable Disease Control and Prevention, Nanjing Center for Disease Control and Prevention, Nanjing 210003, China

Funds:

Nanjing Municipal Medical Science and Technique Development Foundation, China ZKX18049

Nanjing Municipal Medical Science and Technique Development Foundation, China YKK17199

More Information

Corresponding author: HONG Xin, E-mail: nj_hongxin@126.com
Received Date: 2021-09-16
Rev Recd Date: 2022-01-14

Available Online: 2022-06-16

Publish Date: 2022-06-10

Abstract

Abstract

Objective To explore the effect of the interaction of family history of hypertension and dyslipidemia on the prevalence of hypertension. Methods Based on the Chronic Disease and Risk Factor Surveillance in Nanjing City from 2017 to 2018, a representative sample of 61 098 residents aged over 18 years were surveyed. All participants completed face-to-face questionnaires, anthropometric measurements and relevant laboratory examinations. A logistic regression model of complex sampling was utilized to analyze the influence of the family history of hypertension and dyslipidemia on the prevalence of hypertension. The multiplicative and additive models were applied to analyze the interaction effect of family history of hypertension and dyslipidemia. Results Finally, a total of 60 283 subjects were included in this study. Among them, there were 15 686 hypertensive patients with a standardized prevalence rate of 29.8%;33.8% of participants had a family history of hypertension, and the standardized rate of dyslipidemia was 29.8%. After adjusting for confounding factors by multivariate Logistic regression, participants with a family history of hypertension and dyslipidemia had a significantly higher risk of hypertension compared with those without a family history of hypertension and dyslipidemia (OR=4.881, 95% CI: 4.381-5.438). There was a multiplicative interaction between a family history of hypertension and dyslipidemia (OR=1.107, 95% CI: 1.015-1.208). The additive interaction model showed a synergistic effect between a family history of hypertension and dyslipidemia, the S, RERI, API% was 1.603(95%CI: 1.447-1.775), 1.460(95%CI: 1.212-1.707), and 29.9%(95%CI: 24.8-35.0), respectively. Conclusion Family history of hypertension and dyslipidemia has synergistic impact on risk of hypertension, and the simultaneous presence of both increases the risk of hypertension.
- Hypertension,
- Dyslipidemia,
- Family history of hypertension,
- Interaction

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References(21)

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