The complete gene sequence characteristic analysis of coxsackievirus A6 strains isolated from China

DONG Xiao-cong; JI Wang-quan; CHEN Shuai-yin; YANG Hai-yan; DUAN Guang-cai; JIN Yue-fei

doi:10.16462/j.cnki.zhjbkz.2022.06.022

Volume 26 Issue 6

Jun. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(6): 740-744

DONG Xiao-cong, JI Wang-quan, CHEN Shuai-yin, YANG Hai-yan, DUAN Guang-cai, JIN Yue-fei. The complete gene sequence characteristic analysis of coxsackievirus A6 strains isolated from China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2022.06.022

Citation:

DONG Xiao-cong, JI Wang-quan, CHEN Shuai-yin, YANG Hai-yan, DUAN Guang-cai, JIN Yue-fei. The complete gene sequence characteristic analysis of coxsackievirus A6 strains isolated from China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2022.06.022

Citation:

DONG Xiao-cong, JI Wang-quan, CHEN Shuai-yin, YANG Hai-yan, DUAN Guang-cai, JIN Yue-fei. The complete gene sequence characteristic analysis of coxsackievirus A6 strains isolated from China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(6): 740-744. doi: 10.16462/j.cnki.zhjbkz.2022.06.022

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The complete gene sequence characteristic analysis of coxsackievirus A6 strains isolated from China

doi: 10.16462/j.cnki.zhjbkz.2022.06.022

Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China

Funds:

National Natural Science Foundation of China 82002147

National Natural Science Foundation of China 82073618

China Postdoctoral Science Foundation 2019M662543

Key Scientific Research Project of Henan Institution of Higher Education 20A330004

Key Scientific Research Project of Henan Institution of Higher Education 21A310026

More Information

Corresponding author: JIN Yue-fei, E-mail: jyf201907@zzu.edu.cn
Received Date: 2021-07-29
Rev Recd Date: 2022-01-14

Available Online: 2022-06-16

Publish Date: 2022-06-10

Abstract

Abstract

Objective To analyze the genetic evolutionary characteristic of coxsackievirus A6 (CVA6) strains reported from 2007 to 2019 of China to provide theoretical basis for disease prevention and development of vaccines. Methods The whole information of gene sequences of 454 Chiness CVA6 strains reported up to March 1, 2021 were collected from Genbank, and the isolation year and region of the strains were analyzed. Phylogenetic tree was constructed to reveal the evolutionary character of the strains and gene recombination analysis was conducted. Results The information of isolated region showed that the CVA6 strains were mainly originated from coastal areas and south of China. The number of reported CVA6 strains had a significant increase since 2013. The phylogenetic tree revealed that 454 CVA6 strains were mainly clustered into 10 branches. Three strains in Group A isolated from Jiangxi Province was most closely related to the CVA6 prototype strain Gdula (AY421764), with nearly 100% similarity of nucleic acid sequence. Group J isolated from many provinces in China, such as Shandong Province and Guangdong Province, was the most widespread group of strains. Recombination analysis showed that gene recombination of most strains was common. Most representative strains of CVA6 were recombined with some other Enterovirus A strains in P2 and P3 regions. Conclusion From 2007 to 2019, the CVA6 strains have been spreading widely in China, and the phenomenon of gene recombination among CVA6 strains is widespread.
- Hand foot and mouth disease,
- CVA6,
- Phyletic evolution,
- Gene recombination

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References(27)

References

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