Morbidity and influencing factors of congenital syphilis in newborns in Hubei of China, 2015-2020

XU Yang-huan; ZHANG Fan; DAI Guo-hong; LI De-hai; MA Yan-xia; ZHANG Ying; YAN Jiong

doi:10.16462/j.cnki.zhjbkz.2022.09.008

Volume 26 Issue 9

Sep. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(9): 1030-1036

XU Yang-huan, ZHANG Fan, DAI Guo-hong, LI De-hai, MA Yan-xia, ZHANG Ying, YAN Jiong. Morbidity and influencing factors of congenital syphilis in newborns in Hubei of China, 2015-2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1030-1036. doi: 10.16462/j.cnki.zhjbkz.2022.09.008

Citation:

XU Yang-huan, ZHANG Fan, DAI Guo-hong, LI De-hai, MA Yan-xia, ZHANG Ying, YAN Jiong. Morbidity and influencing factors of congenital syphilis in newborns in Hubei of China, 2015-2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1030-1036. doi: 10.16462/j.cnki.zhjbkz.2022.09.008

Citation:

XU Yang-huan, ZHANG Fan, DAI Guo-hong, LI De-hai, MA Yan-xia, ZHANG Ying, YAN Jiong. Morbidity and influencing factors of congenital syphilis in newborns in Hubei of China, 2015-2020[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1030-1036. doi: 10.16462/j.cnki.zhjbkz.2022.09.008

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Morbidity and influencing factors of congenital syphilis in newborns in Hubei of China, 2015-2020

doi: 10.16462/j.cnki.zhjbkz.2022.09.008

1.
Health Care Department, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, China
2.
Infectious Disease Prevention and Control Institute, Hubei Province Center for Disease Control and Prevention, Wuhan 430079, China

Funds:

"2020 Biostime Maternal and Child Nutrition and Health Research Project" of National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention 2020FYH008

More Information

Corresponding author: YAN Jiong, E-mail: 514140326@qq.com
Received Date: 2021-11-09
Rev Recd Date: 2022-02-21

Available Online: 2022-09-17

Publish Date: 2022-09-10

Abstract

Abstract

Objective To investigate the epidemiological characteristics of pregnant women with syphilis and the prevalence of congenital syphilis in their children in Hubei Province, and to explore the related influencing factors of congenital syphilis. Methods Data of syphilitic pregnant women was collected from the national integrated prevention of mother-to-child transmission of HIV, syphilis, and HBV information management system from January 1, 2015, and December 31, 2020. The demographic characteristics, detection and treatment of syphilis, and the prevalence of congenital syphilis were analyzed. A multiple logistic regression model was used to analyze the influencing factors of congenital syphilis. Results The average age of 3 467 syphilis-infected pregnant women was (29.79±5.43) years old, and the rate of mother-to-child transmission was 3.17% (110 cases). About 73.35% (2 543 cases) had received antisyphilitic treatment, 49.21% (1 706 cases) had received standard treatment, and 74.82% (2 594 cases) of children exposed to syphilis received preventive treatment. Multivariate analysis showed that the parturition or postpartum period of syphilis was diagnosed (OR=1.879, 95% CI: 1.237-2.853), the status of syphilis infection of husband/sexual partner (OR=3.762, 95% CI: 1.473-9.608), non-treatment (OR=6.360, 95% CI: 3.316-12.199), nonstandard treatment (OR=4.714, 95% CI: 2.385-9.320), the last non-treponema pallidum antigen serologic test result≥1∶8 (OR=8.908, 95% CI: 1.840-43.131), preventive treatment for exposed children (OR=0.559, 95% CI: 0.369-0.846) and term birth (OR=0.496, 95% CI: 0.300-0.821) were independent factors affecting the prevalence of congenital syphilis (all P < 0.05). Conclusions The incidence of congenital syphilis was closely related to the diagnosis period of syphilitic pregnant women, the non-treponema pallidum antigen serologic test result at the last test during pregnancy, treatment condition, the gestational age of delivery, the status of syphilis infection of husband/sexual partner and preventive treatment condition of exposed children. Early diagnosis, standardized treatment and preventive treatment of exposed children were beneficial to reduce the occurrence of congenital syphilis.
- Syphilis,
- Pregnant women,
- Congenital syphilis,
- Influencing factors

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References(22)

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