Effects of exposure to bisphenol A on estrogen homeostasis based on the biomonitoring method in pregnant women

WU Lin-ying; WANG Yi; XUAN Dong-liang; WANG Yuan-ping; TIAN Jing; YANG Zi-chen; HAN Ming-hui; WANG He-xing; PENG Qian; JIANG Qing-wu

doi:10.16462/j.cnki.zhjbkz.2022.09.018

Volume 26 Issue 9

Sep. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(9): 1097-1101

WU Lin-ying, WANG Yi, XUAN Dong-liang, WANG Yuan-ping, TIAN Jing, YANG Zi-chen, HAN Ming-hui, WANG He-xing, PENG Qian, JIANG Qing-wu. Effects of exposure to bisphenol A on estrogen homeostasis based on the biomonitoring method in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1097-1101. doi: 10.16462/j.cnki.zhjbkz.2022.09.018

Citation:

WU Lin-ying, WANG Yi, XUAN Dong-liang, WANG Yuan-ping, TIAN Jing, YANG Zi-chen, HAN Ming-hui, WANG He-xing, PENG Qian, JIANG Qing-wu. Effects of exposure to bisphenol A on estrogen homeostasis based on the biomonitoring method in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1097-1101. doi: 10.16462/j.cnki.zhjbkz.2022.09.018

Citation:

WU Lin-ying, WANG Yi, XUAN Dong-liang, WANG Yuan-ping, TIAN Jing, YANG Zi-chen, HAN Ming-hui, WANG He-xing, PENG Qian, JIANG Qing-wu. Effects of exposure to bisphenol A on estrogen homeostasis based on the biomonitoring method in pregnant women[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(9): 1097-1101. doi: 10.16462/j.cnki.zhjbkz.2022.09.018

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Effects of exposure to bisphenol A on estrogen homeostasis based on the biomonitoring method in pregnant women

doi: 10.16462/j.cnki.zhjbkz.2022.09.018

1.
Physical and Chemical Laboratory, Jiading District for Disease Control and Prevention, Shanghai 201899, China
2.
Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Shanghai 200032, China
3.
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China

WU Lin-ying and WANG Yi contributed equally to this work

Funds:

National Natural Science Foundation of China 82073638

More Information

Corresponding author: WANG He-xing, E-mail: wanghexing@fudan.edu.cn; PENG Qian, E-mail: peng59991569@163.com
Received Date: 2022-03-31
Rev Recd Date: 2022-05-26

Available Online: 2022-09-17

Publish Date: 2022-09-10

Abstract

Abstract

Objective To investigate the effect of bisphenol A (BPA) on estrogen homeostasis during pregnancy. Methods We selected 151 pregnant women in Jiading District, Shanghai, and a questionnaire survey and collection of urine samples were performed for them.The concentrations of BPA, estrone, 17β-estradiol, and estriol in their urine were determined by ultra-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and corrected by the level of urinary creatinine.The corrected concentrations were transformed by a natural logarithm.After removing outliers, the relationship between urinary BPA and urinary estrogen was analyzed by multiple linear regression analysis. Results The positive rate of urinary BPA in urine samples of pregnant women was 99.34%.After the correction of the urinary creatinine level, the median urinary BPA concentration was 0.65 μg/g.Age, gestational week, total annual household income, second-hand smoke exposure and educational level did not affect urinary BPA level.Urinary estrogen levels were raised with the development of pregnancy.Multiple linear regression analysis showed that urinary BPA level was positively associated with estrone level (β=0.171, 95%CI: 0.006-0.336) and 17β-estradiol level (β=0.137, 95%CI: 0.000-0.274) in all pregnant women.There was a positive correlation between urinary BPA level and urinary estrone level in pregnant women during the third trimester (β=0.449, 95%CI: 0.014-0.884). Conclusions Pregnant women in Shanghai are generally exposed to BPA, and the exposure level of BPA during pregnancy may affect estrogen homeostasis.
- Pregnant women,
- Bisphenol A,
- Estrogen

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References(17)

References

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